Article
Clinical Neurology
Eleonora De Matteis, Valeria Caponnetto, Alfonsina Casalena, Ilaria Frattale, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Maddestra, Stefano Viola, Francesca Pistoia, Simona Sacco, Raffaele Ornello
Summary: Patients with migraine who experience cranial autonomic symptoms (CAS) during attacks may have a higher trigeminovascular activation than those without CAS. This study found that CAS was associated with a better response to anti-CGRP monoclonal antibody treatments.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Salvatore Lo Cascio, Edvige Correnti, Sofia D'Agostino, Mariarita Capizzi, Antonio Marino, Raffaele Meli, Salvatore Lo Nobile, Vincenzo Raieli
Summary: The presence of CAS in migraine, usually associated with trigeminal autonomic cephalalgias, has also been reported in adult and pediatric populations. Experimental evidence suggests that increased parasympathetic outflow can enhance the sensitization of nociceptive receptors involved in migraine. Identifying and understanding these symptoms in migraine may be crucial for diagnosis and effective management.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Clinical Neurology
Mansoureh Togha, Elham Jafari, Atieh Moosavian, Abolfazl Farbod, Shadi Ariyanfar, Fatemeh Farham
Summary: Cranial autonomic symptoms are common in migraine patients, with eye redness and tearing being the most common. Patients with these symptoms tend to have more frequent and severe headache attacks, and may progress to chronic migraine.
Review
Medicine, General & Internal
Beatriz Nunes Vicente, Renato Oliveira, Isabel Pavao Martins, Raquel Gil-Gouveia
Summary: This review focuses on the prevalence, pathophysiology, and clinical characteristics of cranial autonomic symptoms and neck pain in migraine, highlighting their importance in the differential diagnosis. Cranial autonomic symptoms, such as aural fullness, lacrimation, facial sweating, and conjunctival injection, are associated with more severe and frequent migraine attacks. Neck pain can act as a prodromal symptom or trigger for migraines and is correlated with treatment resistance and disability.
Article
Clinical Neurology
Daisuke Danno, Johanna Wolf, Kumiko Ishizaki, Shoji Kikui, Koichi Hirata, Takao Takeshima
Summary: This study investigated the relationship between cranial autonomic symptoms (CASs) and central sensitization in migraine patients. The results showed that migraine patients with CASs had significantly greater central sensitization, and cranial parasympathetic symptoms were more frequent in centrally sensitized patients.
Article
Clinical Neurology
Nazia Karsan, Karthik Nagaraj, Peter J. Goadsby
Summary: This study found that cranial autonomic symptoms (CAS) are common in migraine patients and are associated with increased headache frequency and lateralization of headaches. Voice change and throat swelling may be parasympathetically-mediated CAS and may be associated with aural fullness.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Charlotte Gronvold Christensen, Tanya Ramdal Techlo, Lisette J. A. Kogelman, Lise Wegner Thorner, Janna Nissen, Erik Sorensen, Jes Olesen, Thomas Folkmann Hansen, Mona Ameri Chalmer
Summary: This study estimated the prevalence of migraine with cranial autonomic symptoms in a large population-based sample and validated the questionnaire-based diagnosis. The most common symptoms were facial sweating and lacrimation. The study suggests the need for further research on this possible migraine endophenotype.
Article
Clinical Neurology
Christina Deligianni, Lanfranco Pellesi, Basit Ali Chaudhry, Anne Luise Haulund Vollesen, Agneta Henriette Snoer, Jens Hannibal, Rigmor Hojland Jensen, Messoud Ashina
Summary: In this study, the researchers investigated the effects of PACAP and VIP on plasma levels of VIP and their contribution to induced cluster headache attacks. The results showed a significant increase in plasma VIP levels during PACAP infusion in individuals with episodic cluster headache, but not in those with chronic cluster headache. Further studies are needed to understand the role of VIP and the parasympathetic system in cluster headache.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Fatma Hanci, Yasemin Baranoglu Kilinc, Erkan Kilinc, Sevim Turay, Mustafa Dilek, Nimet Kabakus
Summary: The study found that plasma levels of PACAP-38 and vasoactive intestinal peptide were higher in pediatric migraine patients compared to controls, while levels of calcitonin gene-related peptide and substance P remained unchanged. No significant difference in neuropeptide levels was found between attack and attack-free periods.
Article
Clinical Neurology
Ashutosh Tiwari, Pradeep K. Maurya, Abdul Qavi, Dinkar Kulshreshtha, Anup K. Thacker, Ajai K. Singh
Summary: The study found that cranial autonomic symptoms are common in migraine patients and most patients have bilateral symptoms. Sunlight is a common trigger for headaches.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2022)
Review
Clinical Neurology
Patricia Pozo-Rosich, Gianluca Coppola, Julio Pascual, Todd J. Schwedt
Summary: Data from various studies have been utilized to develop chronic migraine biomarkers, which may assist with diagnosis, prognosticating patient outcomes, predicting treatment responses, etc. However, further optimization and validation are still needed.
Article
Clinical Neurology
Modar Khalil, David Moreno-Ajona, Maria Dolores Villar-Martinez, Fiona Greenwood, Jan Hoffmann, Peter J. Goadsby
Summary: Our study evaluated the efficacy and tolerability of erenumab in managing chronic migraine in a tertiary care setting. The results showed significant reduction in monthly migraine days and overall improvement in other variables at 3 months. More than half of the patients experienced a clinically meaningful improvement in migraine days. No serious adverse events were reported.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Simone Quintana, Marco Russo, Gian Camillo Manzoni, Paola Torelli
Summary: This observational study compares the efficacy, safety, and impact of anti-CGRP monoclonal antibodies on additional parameters such as disability in social, family, and work activities.
NEUROLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Simon Akerman, Peter J. Goadsby, Marcela Romero-Reyes
Summary: This study investigates the role of PACAP-38 in modulating cranial-autonomic and trigeminovascular responses related to headaches. The findings suggest that PACAP-38 regulates headache-related cranial-autonomic and trigeminal-vascular responses via peripheral and central components of the cranial parasympathetic projection.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Jessica Ailani, Peter McAllister, Paul K. Winner, George Chakhava, Mette Krog Josiassen, Annika Lindsten, Bjorn Sperling, Anders Ettrup, Roger Cady
Summary: Eptinezumab administered during a migraine attack resulted in early separation from placebo in terms of headache pain freedom/relief, absence of most bothersome symptom, absence of photophobia, phonophobia, and nausea. This suggests a potential peripheral pharmacological action for CGRP blockade.
Article
Statistics & Probability
Pablo Martinez-Camblor
Summary: This study investigates the feasibility of using the overlap coefficient (OVL) in binary classification problems. The findings indicate that the OVL does not provide additional information and the previously reported advantages are based on the assumption that larger values of the marker are assigned higher probabilities in the classification process. By examining the ability of white blood cell counts to identify different types of meningitis, the problem is further illustrated.
COMMUNICATIONS IN STATISTICS-THEORY AND METHODS
(2023)
Article
Mathematical & Computational Biology
Pablo Martinez-Camblor, Todd A. MacKenzie, A. James O'Malley
Summary: The Cox regression model and its associated hazard ratio (HR) are widely used for summarizing the effect of treatments on time to event outcomes. However, interpreting the HR depends on the assumed underlying survival model, which poses challenges. Alternative measures have been proposed to address these concerns. This study examines the properties of a specific marginal Cox regression model and considers its estimation when there is a omitted confounder.
INTERNATIONAL JOURNAL OF BIOSTATISTICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Pablo Martinez-Camblor
Summary: Binary classification problems play a crucial role in biomedicine, involving diagnostic and personalized medicine. We propose an estimation procedure for optimal classification rules and demonstrate its practical use in a real-world problem.
JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION
(2022)
Article
Environmental Sciences
Maria Fernandez-del-Valle, Hugo Olmedillas, Nieves Palacios Gil de Antunano, Ana Maria Ribas, Pablo Martinez-Camblor, Angela Garcia-Gonzalez, Natalia Ubeda, Eduardo Iglesias-Gutierrez
Summary: Combat sports athletes exhibit differences in body weight, body composition, and adiposity. This study found that adiposity levels can influence the agreement between different methods used to estimate body fat. However, the agreement between methods and body fat percentage was not affected by adiposity. Anthropometry was the most accurate method.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Analytical
Baihui Wang, Amanda Moyano, Jose Maria Duque, Luis Sanchez, Guillermo Garcia-Santos, Luis J. Garcia Florez, Esther Serrano-Pertierra, Maria del Carmen Blanco-Lopez
Summary: This study developed a novel lateral flow immunoassay system based on Fe3O4 nanozymes for detecting extracellular vesicles (EVs).
Article
Environmental Sciences
Pablo Martinez-Camblor
Summary: Proportional hazard Cox regression models are commonly used for analyzing time-dependent outcomes, but their interpretation is often subject to misinterpretation due to their strong dependency on underlying assumptions. This study examines the strengths and weaknesses of alternative indices and Cox-type models using synthetic data.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Jesse A. Columbo, Pablo Martinez-Camblor, David H. Stone, Philip P. Goodney, A. James O'Malley
Summary: This study compared the effectiveness of transcarotid artery revascularization (TCAR), carotid endarterectomy (CEA), and transfemoral carotid artery stenting (TF-CAS) in patients with carotid artery stenosis. The results showed that TCAR had a higher rate of stroke or death during the perioperative period, but there was no statistically significant difference in stroke or death between the three procedures at 1 year. TCAR may be a safe alternative to CEA and TF-CAS, especially for symptomatic patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Anesthesiology
Hedwig Schroeck, Michaela A. Whitty, Pablo Martinez-Camblor, Stefana Voicu, Barbara K. Burian, Andreas H. Taenzer
Summary: This study compares the difference in anaesthesia clinicians' perception of safety, workload, anxiety, and stress when performing similar neurosurgical procedures in either the operating room (OR) or a remote MRI room. The results show that working in the remote MRI room is associated with lower perceived safety and higher workload, anxiety, and stress for anaesthesia clinicians.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Statistics & Probability
Pablo Martinez-Camblor, Susana Diaz-Coto
Summary: The generalized receiver-operating characteristic (gROC) curve is used to evaluate diagnostic tests that have different associations with positive results for higher and lower marker values. However, using the same data to select classification subsets and calculate the gROC curve leads to over-optimistic estimates of future performance. This study explores the bias of the empirical gROC curve estimator and proposes cross-validation based algorithms to reduce overfitting, improving the estimation of diagnostic accuracy.
COMPUTATIONAL STATISTICS
(2023)
Article
Health Care Sciences & Services
Pablo Martinez-Camblor
Summary: A good diagnostic test should exhibit distinct behavior for positive and negative populations, but that is not sufficient to create a good classification system. Defining decision criteria is crucial for solving the complex binary classification problem. The receiver-operating characteristic curve length serves as an index for the optimal discriminatory capacity of a biomarker, but its estimation requires parametric or smoothed models. This study examines a kernel density estimator-based approximation for estimating the length of the receiver-operating characteristic curve and explores its behavior through statistical analysis and Monte Carlo simulations with real-world examples.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jesse A. Columbo, David H. Stone, Pablo Martinez-Camblor, Philip P. Goodney, A. James O'Malley
Summary: In 2015, TCAR was approved by the FDA as a treatment option for high-risk patients with carotid stenosis. This study shows an increasing trend in TCAR utilization, with TCAR representing nearly 1-in-4 procedures at centers offering it. The results suggest the need for high-quality registry-based analyses to evaluate TCAR's real-world outcomes and durability.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cell Biology
Ruben Rodriguez, Isabel Gaivao, Leticia Aguado, Marta Espina, Jorge Garcia, Pablo Martinez-Camblor, L. Maria Sierra
Summary: This study used Drosophila to investigate the interactions between DNA damage responses and repair pathways. The findings showed that both nucleotide excision repair and dmPolQ pathways had an additive effect on the response to MMS-induced DNA damage. The results suggest that Drosophila could be an excellent model for studying interactions between repair pathways.
Article
Mathematics
Rocio Fernandez-Iglesias, Pablo Martinez-Camblor, Adonina Tardon, Ana Fernandez-Somoano
Summary: This study presents an analysis of cardiovascular measures in children, discussing the challenges in dealing with missing data and selecting the appropriate regression model. It also explores the impact of different decisions on the results.
Article
Mathematical & Computational Biology
Pablo Martinez-Camblor, Susana Diaz-Coto
Summary: Data description is the first step in understanding the nature of the problem. This research revisits the incidence rate estimator under right-censorship and analyzes its impact on observed results. A solution is proposed to limit the impact of data collection on hypothesis testing results.
INTERNATIONAL JOURNAL OF BIOSTATISTICS
(2023)
Review
Respiratory System
Jose Sanz-Santos, Pere Almagro, Komal Malik, Pablo Martinez-Camblor, Conxi Caro, Ramon Rami-Porta
Summary: The current guidelines recommend invasive staging for non-small cell lung cancer (NSCLC) with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). However, the indication for confirming a negative EBUS-TBNA result with video-assisted mediastinoscopy (VAM) before resection varies in different guidelines. This study evaluates the evidence for the added value of confirmatory VAM after a negative EBUS-TBNA result in NSCLC mediastinal staging, and finds that confirmatory VAM can reduce the rate of unforeseen N2/3 disease, but with a high number needed to treat (NNT), and should be recommended only for specific cases yet to be defined.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
