Journal
FITOTERAPIA
Volume 142, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2020.104498
Keywords
Mallotus macrostachyus; Triterpenoids; Structure elucidation; Anti-inflammatory activity
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Funding
- National Natural Science Foundation of China [21877071, 21472113]
- Science & Technology Development Plan Project of Shandong Province [2014GSF118023]
- Young Scholars Program of Shandong University [YSPSDU2015WLJH50]
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Three new triterpenoids, mallomacrostins A-C (1-3), and 11 known ones (4-14) were obtained from the twigs and leaves of Mallotus macrostachyus. Mallomacrostin A possessed a new trinor-D:B-friedobaccharane skeleton. The structures of the new compounds were elucidated on the basis of extensive spectroscopic techniques including HR-ESIMS and NMR and the structure of 1 was confirmed by single crystal X-ray diffraction analysis. Spectroscopic data of the known compound 4 were provided for the first time. Compounds 2 and 10 exhibited significant anti-inflammatory activity by inhibiting LPS-induced release of nitric oxide with IC50 of 70.0 mu M and 14.0 mu M, respectively.
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