Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Seunghun S. Lee, Nicole Kleger, Gisela A. Kuhn, Helen Greutert, Xiaoyu Du, Thijs Smit, Andre R. Studart, Stephen J. Ferguson
Summary: Digital Light Processing is used to fabricate a hive-structured assemblable bespoke scaffold (HIVE) that can be manually assembled and customized for specific defect. It can be filled with different biological factors in different areas to provide site-specific treatments. Through in vitro and in vivo experiments, it has been shown to induce osteogenesis and angiogenesis in a controlled manner.
ADVANCED MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Hao Li, Zhiyao Liao, Zhen Yang, Cangjian Gao, Liwei Fu, Pinxue Li, Tianyuan Zhao, Fuyang Cao, Wei Chen, Zhiguo Yuan, Xiang Sui, Shuyun Liu, Quanyi Guo
Summary: This study presents a composite scaffold for meniscus tissue engineering, consisting of a 3D-printed PCL scaffold, injected MECM, and KGN-loaded PLGA microspheres. The combination showed enhanced hydrophilicity, bioactivity, cell adhesion, proliferation, and chondrogenic differentiation. The sustained release of KGN from the scaffold contributed to improved cell affinity and chondrogenic activity, indicating promising application prospects in MTE.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Multidisciplinary
Yubo Tao, Mengmeng Liu, Wenjia Han, Peng Li
Summary: Developing 3D printable waste paper based biocomposites as a greener alternative to traditional recycling methods, the study found that adding waste office paper (WOP) improved melt flow abilities of composites. However, increasing WOP content resulted in decreased tensile strengths of prints, which were significantly enhanced post KH570 treatment.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Engineering, Multidisciplinary
Lin Zou, Le Hu, Panpan Pan, Solaiman Tarafder, Mingzu Du, Yusheng Geng, Gan Xu, Li Chen, Jingdi Chen, Chang H. Lee
Summary: The polycaprolactone and nano-hydroxyapatite composite is a promising material for bone scaffolds with excellent mechanical properties. In this study, a 3D printed scaffold embedded with poly (lactic-co-glycolic acid) microspheres was developed for controlled delivery of Icariin to promote bone regeneration.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Yong Sang Cho, Min-Soo Ghim, Myoung Wha Hong, Young Yul Kim, Young-Sam Cho
Summary: This study aimed to guide the endogenous regeneration of bone defects by designing collagen patterns loaded with bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2) on a 3D-printed polycaprolactone/nano-hydroxyapatite scaffold. The results demonstrated that the polycaprolactone/nano-hydroxyapatite/collagen scaffold with a radial pattern promoted endogenous bone regeneration and angiogenesis compared to scaffolds with positive and edge patterns.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Composites
J. Nagarjun, J. Kanchana, G. Rajeshkumar, A. Anto Dilip
Summary: The significance and interest of printing green composites in three dimensions have recently grown. In this study, kernel powder obtained from Tamarindus indica seeds was added to polylactic acid (PLA) and printed using Fused Deposition Modeling. The composite with 2% filler concentration showed improved overall strength compared to neat PLA matrix, but performance depreciated with higher filler concentrations.
POLYMER COMPOSITES
(2023)
Article
Engineering, Environmental
Guocheng Ding, Xinpan Li, Muyang Sun, Yangyang He, Fengyuan Zhao, Tong Wu, Junyan Wang, Shuang Ren, Weili Shi, Luzheng Xu, Xiaoqing Hu, Wei Huang, Ran Yu, Yingfang Ao
Summary: This study presents a novel tissue engineering meniscus scaffold prepared using 3D printing technology, which shows great potential in promoting meniscus regeneration, protecting articular cartilage, and mitigating the development of osteoarthritis. It addresses the challenges posed by polyurethane in existing meniscus grafts and provides a next-generation clinical meniscus biomaterial repair strategy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yunsheng Dong, Hui Xiao, Jie Wang, Tingting Yang, Naiqi Kang, Jiaxing Huang, Wei Cui, Yufei Liu, Qiang Yang, Shufang Wang
Summary: Constructing scaffolds with osteogenic activity through tissue engineering is an effective strategy for bone regeneration. This study used gelatin, silk fibroin, and Si3N4 to prepare silicon-functionalized bio-macromolecules composite scaffolds using 3DP technology. The scaffold showed good cyto-compatibility and promoted osteogenic differentiation of MSCs in vitro, and facilitated bone regeneration in vivo. The composite scaffold system has great potential for application in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Engineering, Environmental
Rezgar Hasanzadeh, Peyman Mihankhah, Taher Azdast, Asghar Rasouli, Mohadese Shamkhali, Chul B. Park
Summary: This article introduces the advantages and applications of 3D and 4D printing in fabricating tissue engineering scaffolds, with a focus on the potential of hydrogels in 4D printing scaffolds. Furthermore, the effects of 3D and 4D printing parameters on the mechanical, morphological, and biological properties of scaffolds are investigated.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Kenny Man, Mathieu Y. Brunet, Sophie Louth, Thomas E. Robinson, Maria Fernandez-Rhodes, Soraya Williams, Angelica S. Federici, Owen G. Davies, David A. Hoey, Sophie C. Cox
Summary: The study showed that 3D printed titanium scaffolds coated with hydroxyapatite can enhance the therapeutic efficacy of osteoblast-derived EVs. Triangle pore scaffolds significantly increased osteoblast mineralization and EV yield, demonstrating the potential for bone repair. Coating with bone-mimetic nano-needle hydroxyapatite further improved osteoblast mineralization and EV production, highlighting the importance of harnessing bone-mimetic culture platforms for regenerative medicine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Zheng-Tian Xie, Jinfeng Zeng, Dong-Hee Kang, Shigeyoshi Saito, Shigeru Miyagawa, Yoshiki Sawa, Michiya Matsusaki
Summary: 3D printing with a microgel-based supporting bath allows the construction of complex structures using soft and watery biomaterials, but low print resolution has limited its practical applications in tissue engineering. In this study, high-resolution printing of a 3D collagen organ scaffold was achieved by using an engineered Gellan gum (GG) microgel bath containing trisodium citrate (TSC). The addition of TSC improved the bath's morphology and suppressed collagen ink diffusion, leading to improved print resolution. Successfully printed collagen organ structures demonstrated high shape fidelity, and the resulting collagen products showed good cell affinity in tissue scaffold applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yaowei Xuan, Lin Li, Chenping Zhang, Min Zhang, Junkai Cao, Zhen Zhang
Summary: Structurally ordered BRT-O scaffolds fabricated by 3D printing technique showed excellent biological activity and promoted bone regeneration through macrophage polarization. Compared with other control groups, BRT-O scaffolds exhibited higher biodegradability and the ability to regulate macrophage polarization, resulting in better outcomes in promoting bone regeneration.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Manufacturing
Haijun He, Kolos Molnar
Summary: A novel fabrication process was proposed in this study, utilizing nanofiber interleaves in 3D printed structures to enhance mechanical properties. By improving the morphology of nanofibers at the interlaminar interface and controlling nanofiber content, improvements were observed in the mechanical properties of nanocomposites.
ADDITIVE MANUFACTURING
(2021)
Article
Materials Science, Multidisciplinary
Jae Seo Lee, Haram Nah, Donghyun Lee, Sang-Hyun An, Wan-Kyu Ko, Sang Jin Lee, Seung Yeon Lee, Kyung Min Park, Jung Bok Lee, Hyeong-joong Yi, Il Keun Kwon, Kyu-Sun Choi, Dong Nyoung Heo
Summary: Reconstructing patient-specific scaffolds for repairing uniquely shaped bone defects is a major challenge in tissue engineering. 3D printed scaffolds have gained attention as a promising technology for rapid generation of custom shapes. However, commonly used synthetic polymers lack the biological capacity to mimic native extracellular matrix functions. This study describes the preparation and characterization of a 3D hybrid model for bone tissue engineering that incorporates an extracellular matrix-enriched hydrogel in a synthetic polymer scaffold, showing excellent biocompatibility and osteogenic activity.
MATERIALS & DESIGN
(2022)
Article
Multidisciplinary Sciences
Xiaoming Xu, Yuanming Zhang, Yong Chen, Changhao Liu, Wenjing Wang, Jiajia Wang, Huiting Huang, Jianyong Feng, Zhaosheng Li, Zhigang Zou
Summary: This study confirms the formation of key species *OOH in a heterogeneous system and finds that *OOH is more conducive to charge transfer behavior and the activation of an O-O bond compared to *H2O2. It proposes a method of improving the local coordination structure and electronic density of the catalyst to reduce the activation barrier of H2O2 and improve the production efficiency of center-dot OH. The study also reveals the center-dot OH free radical activity mechanism and molecular transformation pathways of 4-chloro phenol (4-CP).
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Energy & Fuels
Zhi Zhu, Jianyong Feng, Xiaopeng Han, Chunxiong Bao, Tao Yu, Zhaosheng Li, Zhigang Zou
Summary: This study highlights the importance of considering the ambient temperature in the evaporation rate of the solvent during the growth of CsPbIBr2 film by solvent-controlled strategy.
Article
Chemistry, Physical
Yingfei Hu, Yujia Qi, Mingyu Pi, Yi Qiao, Lingyun Hao, Yuanyuan Wang, Hangmin Guan, Jianyong Feng
Summary: Efficient and low-cost electrocatalysts for hydrogen evolution reaction (HER) are synthesized by synthesizing two different types of CoS2 under low sulfur and high sulfur concentration conditions. The study shows that CoS impurity phase is easily formed when the sulfur concentration is low, while at high sulfur concentration, the growth of CoS impurity phase is inhibited and leads to phase-pure CoS2. The electrochemical investigation reveals that the CoS2 (HS) electrode has a higher onset potential and a lower required overpotential compared to the CoS2 (LS) electrode.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Cell Biology
Jianpeng Han, Yan Zhou, Chundong Zhang, Jianyong Feng, Junhao Wang, Kuo Guo, Wenbin Chen, Yongzhang Li
Summary: Discordant abundances of different immune cell subtypes is regarded to be an essential feature of tumour tissue. Direct studies in Prostate cancer (PC) of intratumoral immune heterogeneity characterized by immune cell subtype, are still lacking. Using the single sample gene set enrichment analysis (ssGSEA) algorithm, the abundance of 28 immune cells infiltration (ICI) were determined for PC. A NMF was performed to determine tumour-sample clustering based on the abundance of ICI and PFS information. Hub genes of clusters were identified via weighted gene co-expression network analysis (WGCNA). The multivariate dimensionality reduction analysis of hub genes expression matrix was carried out via principal component analysis (PCA) to obtain immune score (IS). We analysed the correlation between clustering, IS and clinical phenotype. We divided the 495 patients into clusterA (n = 193) and clusterB (n = 302) on the basis of ICI and PFS via NMF. The progression-free survival (PFS) were better for clusterA than for clusterB (p < 0.001). Each immune cell subtypes was more abundant in clusterA than in clusterB (p < 0.001). The expression levels of CTAL-4 and PD-L1 were lower in clusterB than in clusterA (p < 0.001 and p = 0.006). We obtained 103 hub genes via WGCNA. In the training and validation cohorts, the prognosis of high IS group was worse than that of the low IS group (p < 0.05). IS had good predictive effect on 5-year PFS. The expression of immune checkpoint genes was higher in the low IS group than in the high IS group (p < 0.01). Patients with low IS and receiving hormone therapy had better prognosis than other groups. The combination of IS and clinical characteristics including lymph node metastasis and gleason score can better differentiate patient outcomes than using it alone. IS was a practical algorithm to predict the prognosis of patients. Advanced PC patients with low IS may be more sensitive to hormone therapy. CXCL10, CXCL5, MMP1, CXCL12, CXCL11, CXCL2, STAT1, IL-6 and TLR2 were hub genes, which may drive the homing of immune cells in tumours and promote immune cell differentiation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Engineering, Chemical
Ruixiang Xu, Jianyong Feng, Lingxiao Zhang, Shengquan Li
Summary: This study developed an organic-inorganic hybrid ultrafine nanofiber membrane with high efficiency and low pressure drop. The average fiber diameter of the membrane is less than 0.3 micrometers, and its filtration efficiency for PM0.3 is as high as 99.997%. The membrane operates under low air pressure conditions. Therefore, it can be widely used in various applications for air filtration.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Chemistry, Physical
Yingfei Hu, Jun Wang, Huiting Huang, Jianyong Feng, Wangxi Liu, Hangmin Guan, Lingyun Hao, Zhaosheng Li, Zhigang Zou
Summary: A strategy for in situ surface-trap passivation using MgO ions is developed, which successfully eliminates surface traps in CuBi2O4 photocathodes and improves the efficiency of solar water-splitting electrodes.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Chemistry, Multidisciplinary
Wangxi Liu, Yuanqi Wang, Huiting Huang, Jun Wang, Gaoxiang He, Jianyong Feng, Tao Yu, Zhaosheng Li, Zhigang Zou
Summary: Light-driven primary amine oxidation to imines integrated with H2 production presents a promising means to simultaneous production of high-value-added fine chemicals and clean fuels. A spatial decoupling strategy is proposed to overcome the limitations of poor charge separation and uncontrolled hydrogenation. The CoP@ZnIn2S4 photocatalyst exhibits directional and ultrafast carrier separation, leading to significantly higher production rate and selectivity for the photoconversion of benzylamine to N-benzylbenzaldimine.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Engineering, Environmental
Jianyong Feng, Xing Li, Zedong Lu, Yanling Yang, Zhiwei Zhou, Heng Liang
Summary: In this study, ultraviolet irradiation was used to purify the membrane tanks and control membrane biofouling in biofiltration-facilitated GDM systems. The permeate flux significantly increased after UV irradiation, primarily due to the decreased cake layer resistance. UV irradiation also improved the permeability of the biofouling layer, reduced protein content, and altered the bacterial community structure on the membrane surface. Overall, the in-situ application of UV can be an effective strategy to mitigate membrane biofouling.
Article
Engineering, Environmental
Jianyong Feng, Xing Li, Zhiwei Zhou, Yanling Yang, Nan Wang
Summary: This paper investigates the application of gravity-driven up-flow slow biofilter (GUSB) before gravity-driven membrane (GDM) systems to mitigate membrane fouling and explores the spatial distribution of fouling characteristics. The study finds that GUSB pretreatment reduces the cake layer resistance (Rc) and membrane pore resistance (Rp), resulting in an increase in permeate flux. The ratio of protein to polysaccharide (PN/PS) is highly correlated with nanoparticle size and influences the bacterial community and structure of the biofouling layer.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Engineering, Environmental
Jianyong Feng, Xing Li, Yanling Yang, Zhiwei Zhou
Summary: The aluminum-loaded longan shell (LGS-Al) adsorbent exhibits high efficiency in fluoride removal from drinking water with a maximum adsorption capacity of 21.49 mg/g and limited leaching of aluminum and dissolved organic carbon. The removal of fluoride is dominated by the Al-OH site, while Al-Cl is more likely to react with HF.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Oncology
Junhao Wang, Jianpeng Han, Jianyong Feng, Kuo Guo, Wenbin Chen, Yan Zhou, Yongzhang Li
Summary: This study investigated the efficacy of Bushen Huoxue Decoction (BSHXD) combined with moxibustion on inflammation and urinary symptoms in prostate cancer patients. The results showed that the treatment improved patients' lower urinary symptoms, inflammation, and quality of life, but had no effect on the progression of castration-resistant prostate cancer (CRPC).
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Yuan Cao, Linfeng Gao, Bing Wang, Yingfang Yao, Congping Wu, Qing Shen, Jianyong Feng, Yong Zhou, Zhaosheng Li, Zhigang Zou
Summary: Researchers were inspired by the thermal insulation ability of polar bear hairs to create villous carbon frameworks (VCF) embedded with FeNi3 alloys, which greatly improved the oxygen evolution reaction (OER) performance through the photothermal effect, outperforming traditional photothermal electrocatalysts.
ACS MATERIALS LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Huiting Huang, Jun Wang, Minyue Zhao, Ningsi Zhang, Yingfei Hu, Jianyong Feng, Zhaosheng Li, Zhigang Zou
Summary: This study investigates the performance dependence of hematite as the prototype electrode for photoelectrochemical water splitting at different temperatures. The analysis reveals the efficiency loss/gain of each elemental step and the influence of slow water oxidation kinetics on photovoltage generation.
ACS MATERIALS LETTERS
(2022)
Article
Chemistry, Applied
Zhiwei Li, Huiting Huang, Wenjun Luo, Yingfei Hu, Rongli Fan, Zhi Zhu, Jun Wang, Jianyong Feng, Zhaosheng Li, Zhigang Zou
Summary: This study suggests that electrochemical treatment not only removes partial MoO segregations on Mo-doped BiVO4 electrodes, but also initiates the formation of HyMoO surface defects, which provide charge transfer channels for photogenerated holes. The charge separation of the electrodes is significantly enhanced by these charge transfer channels.
CHINESE JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Applied
Shaobo Zhang, Huiting Huang, Zhijie Zhang, Jianyong Feng, Zongguang Liu, Junzhuan Wang, Jun Xu, Zhaosheng Li, Linwei Yu, Kunji Chen, Zhigang Zou
Summary: By combining a progressive tandem junction design with a unique Si nanowire framework, the researchers have successfully developed high-onset-potential photocathodes and enhanced solar hydrogen production. They demonstrated a radial tandem junction thin film water-splitting photocathode for the first time, which utilizes Si nanowires to enable efficient light-trapping and absorption of different wavelengths. The experimental results highlight the potential of this photocathode in large-scale applications, with high photocurrent onset and overall applied-bias photon-to-current efficiency.
CHINESE JOURNAL OF CATALYSIS
(2022)
