The TGF‐b/SOX4 axis and ROS‐driven autophagy co‐mediate CD39 expression in regulatory T‐cells

Microenvironment tailors nTreg structure and function

(2019) Valérie Schiavon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis

(2019) Sara Zumerle et al.   Cell Reports

Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

(2019) Ivan Perrot et al.   Cell Reports

Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells

(2019) Marlene C. Gerner et al.   Frontiers in Pharmacology

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Response of intestinal HT-29 cells to the trichothecene mycotoxin deoxynivalenol and its sulfated conjugates

(2018) Giorgia Del Favero et al.   TOXICOLOGY LETTERS

Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions

(2018) Elise Jacquin et al.   Frontiers in Immunology

Targeting adenosine for cancer immunotherapy

(2018) Robert D. Leone et al.   Journal for ImmunoTherapy of Cancer

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Mutations outside the N-terminal part of RBCK1 may cause polyglucosan body myopathy with immunological dysfunction: expanding the genotype–phenotype spectrum

(2017) Martin Krenn et al.   JOURNAL OF NEUROLOGY

Autophagy dysregulation in Danon disease

(2017) Anna Chiara Nascimbeni et al.   Cell Death & Disease

Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies

(2017) Mansour Haidar et al.   Frontiers in Molecular Neuroscience

What Else Can CD39 Tell Us?

(2017) Hai Zhao et al.   Frontiers in Immunology

Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression

(2016) Belinda Phipson et al.   Annals of Applied Statistics

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

High expression of CD39 in gastric cancer reduces patient outcome following radical resection

(2016) Xiao-Yan Cai et al.   Oncology Letters

Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens

(2016) Georg Gruenbacher et al.   Cell Reports

Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals

(2016) Fengqin Fang et al.   Cell Reports

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

(2015) Sujuan Guo et al.   Autophagy

The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone

(2015) Pierrick G.J. Fournier et al.   CANCER CELL

The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation

(2015) Anne Rissiek et al.   JOURNAL OF AUTOIMMUNITY

Down-regulated SOX4 Expression Suppresses Cell Proliferation, Metastasis and Induces Apoptosis in Xuanwei Female Lung Cancer Patients

(2015) Yongchun Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Helios Controls a Limited Subset of Regulatory T Cell Functions

(2015) Mathew Sebastian et al.   JOURNAL OF IMMUNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine

(2015) Aiping Bai et al.   Nature Communications

Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas

(2015) Cindy Neuzillet et al.   Oncotarget

Contribution of CD39 to the immunosuppressive microenvironment of acute myeloid leukaemia at diagnosis

(2014) Nicolas Dulphy et al.   BRITISH JOURNAL OF HAEMATOLOGY

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Plac8 Links Oncogenic Mutations to Regulation of Autophagy and Is Critical to Pancreatic Cancer Progression

(2014) Conan Kinsey et al.   Cell Reports

Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors

(2013) Sergei Doulatov et al.   Cell Stem Cell

MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α

(2013) Yu-Ming Yeh et al.   INTERNATIONAL JOURNAL OF CANCER

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

Naturally occurring regulatory T cells: markers, mechanisms, and manipulation

(2012) Klaus G. Schmetterer et al.   FASEB JOURNAL

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

(2012) Makoto Kuwahara et al.   NATURE IMMUNOLOGY

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

T-cell specific defect in expression of the NTPDase CD39 as a biomarker for lupus

(2011) Matthew J. Loza et al.   CELLULAR IMMUNOLOGY

Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-β

(2011) Frederico S. Regateiro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Bet v 1–specific T-cell receptor/forkhead box protein 3 transgenic T cells suppress Bet v 1–specific T-cell effector function in an activation-dependent manner

(2011) Klaus G. Schmetterer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Mechanism of Superoxide Production by the Antimycin-inhibited Mitochondrial Q-cycle

(2011) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

(2011) Beat M. Künzli et al.   Purinergic Signalling

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

(2010) B. R. Underwood et al.   HUMAN MOLECULAR GENETICS

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Characterization of Protective Human CD4+CD25+ FOXP3+ Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid

(2010) Ling Lu et al.   PLoS One

Isolated CD39 Expression on CD4+T Cells Denotes both Regulatory and Memory Populations

(2009) Q. Zhou et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer

(2009) M. Mandapathil et al.   CLINICAL CANCER RESEARCH

Increased Frequency and Suppression by Regulatory T Cells in Patients with Acute Myelogenous Leukemia

(2009) M. J. Szczepanski et al.   CLINICAL CANCER RESEARCH

Indispensable Role of the Runx1-Cbfβ Transcription Complex for In Vivo-Suppressive Function of FoxP3+ Regulatory T Cells

(2009) Akihiko Kitoh et al.   IMMUNITY

Human Follicular Lymphoma CD39+-Infiltrating T Cells Contribute to Adenosine-Mediated T Cell Hyporesponsiveness

(2009) S. P. Hilchey et al.   JOURNAL OF IMMUNOLOGY

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

(2009) D. J. Friedman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells

(2008) S. Alice Long et al.   JOURNAL OF AUTOIMMUNITY