Article
Veterinary Sciences
Olasunkanmi S. Olawuwo, Ibukun M. Famuyide, Lyndy J. McGaw
Summary: Antimicrobial resistant poultry pathogens pose a threat to both animal health and human health, and alternative products and strategies are being sought to reduce their prevalence. In this study, extracts from certain plant species showed potential as alternative feed additives in poultry production, with good antibacterial and anti-biofilm activities. Further studies are needed to evaluate their efficacy as herbal feed additives in vivo.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Infectious Diseases
Alexander Zubenko, Victor Kartsev, Anthi Petrou, Athina Geronikaki, Marija Ivanov, Jasmina Glamoclija, Marina Sokovic, Lyudmila Divaeva, Anatolii Morkovnik, Alexander Klimenko
Summary: In this study, a series of novel heteroarylated benzothiazoles with antimicrobial activity were designed, prepared, and studied. These compounds showed moderate antibacterial activity, with compound 2j being the most potent. They also exhibited good antifungal activity, with compound 2d being the most active. Docking studies suggested that inhibition of E. coli MurB and 14-lanosterol demethylase may be the mechanism behind the antibacterial and antifungal activities of these compounds.
Article
Chemistry, Multidisciplinary
Hayfa Habes Almutairi, Nazish Parveen, Sajid Ali Ansari
Summary: The study aimed to synthesize silver-copper oxide nanohybrids with different silver concentrations and characterize their physico-chemical properties. The nanohybrids showed promising antimicrobial activity against E. coli and C. albicans, as well as antiproliferative effects on human colon cancer cells.
Article
Biochemistry & Molecular Biology
Lidia Lungu, Caleria Cucicova, Svetlana Blaja, Alexandru Ciocarlan, Ion Dragalin, Alic Barba, Nicoleta Vornicu, Elisabeta-Irina Geana, Ionel I. Mangalagiu, Aculina Aricu
Summary: A series of compounds containing 1,3-benzothiazole groups were synthesized and their biological activities were evaluated, showing some compounds with high antifungal and antibacterial activity.
Article
Chemistry, Medicinal
Abdulrahman S. Bazaid, Abdu Aldarhami, Mitesh Patel, Mohd Adnan, Assia Hamdi, Mejdi Snoussi, Husam Qanash, Mohammed Imam, Mohammad Khalil Monjed, Aiah Mustafa Khateb
Summary: Sumra honey exhibits potential antimicrobial activity against multidrug-resistant bacteria and fungi. It also shows promising antibiofilm, anti-quorum-sensing, and antioxidant activities.
Article
Pharmacology & Pharmacy
Ana Gomes, Lucinda J. Bessa, Iva Fernandes, Ricardo Ferraz, Claudia Monteiro, M. Cristina L. Martins, Nuno Mateus, Paula Gameiro, Catia Teixeira, Paula Gomes
Summary: Efficient antibiotics are running out, leading to challenges in infection treatment. Antimicrobial peptides are considered a new hope for the future. The chimeric peptide PP4-3.1 shows potent activity against both Gram-positive and Gram-negative bacteria, making it a promising lead for new topical treatments for severe skin infections.
Article
Chemistry, Multidisciplinary
Tao Wang, Erik Jan Cornel, Chang Li, Jianzhong Du
Summary: Biofilms have become a subject of increasing attention due to their association with bacterial infections. Traditional antibiofilm approaches based on antibiotics are often ineffective in eradicating biofilms due to limited antibiotic diffusion and inactivation. Smart drug delivery systems that target the biofilm interior show promise in overcoming this challenge. This review focuses on methods to improve drug delivery efficiency for enhanced chemotherapy of biofilms, including chemical and physical approaches.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Asem A. Mohamed, Mohammed Abu-Elghait, Nehad E. Ahmed, Salem S. Salem
Summary: This study demonstrated the mycogenic synthesis of medically applied zinc oxide and copper oxide nanoparticles. The nanoparticles showed high antimicrobial and antibiofilm activities, suggesting their potential for medical applications in limiting the spread of pathogenic microbes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biophysics
Guihua Cao, Jinhong Yan, Xiaoxuan Ning, Qi Zhang, Qi Wu, Long Bi, Yumin Zhang, Yisheng Han, Jianbin Guo
Summary: The review discusses the antibacterial and antibiofilm effects of graphene and its derivatives, including a review of their abilities in solution and on surfaces, as well as exploration of their toxicity and possible mechanisms. Possible future research directions are also proposed.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Multidisciplinary Sciences
Shimaa H. Salem, Saad S. El-Maraghy, Ahmed Y. Abdel-Mallek, Mohamed A. A. Abdel-Rahman, Emad H. M. Hassanein, Osama A. Al-Bedak, Fatma El-Zahraa A. Abd El-Aziz
Summary: In this study, an endophytic fungus Paecilomyces sp. (AUMC 15510) was isolated from a medicinal plant and its ethyl acetate crude extract was found to have significant antimicrobial activity against multiple human microbial pathogens, especially Bacillus subtilis ATCC 6633 and Pseudomonas aeruginosa ATCC 90274. The extract also showed inhibition against biofilm formation of the tested pathogens. Furthermore, the extract exhibited wound healing activity in an earthworm model.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Nikita A. Frolov, Mary A. Seferyan, Anvar B. Valeev, Evgeniya A. Saverina, Elena V. Detusheva, Anatoly N. Vereshchagin
Summary: In this article, we presented a new approach to synthesizing three novel series of bioactive water-soluble tris-quaternary ammonium compounds and evaluated their antimicrobial and antibiofilm potential. The compounds showed significant inhibitory effects against resistant bacteria and effectively eradicated biofilms formed by pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Tao Wu, Yan Yang, He Su, Yuanhui Gu, Quanming Ma, Yan Zhang
Summary: This article reviews the problem of stone recurrence in cholestasis of indwelling biliary stents after endoscopic retrograde cholangio pancreatoraphy (ERCP) and discusses the latest advances in developing antibacterial and antibiofilm coatings to improve the properties of biliary stents. Several possible directions for future development of biliary stent coatings and biliary stents are also listed.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biophysics
Maryam Tavafoghi, Sanchit Garg, Anton Korenevski, Maria Dittrich
Summary: This study investigates the potential of phytoglycogen nanoparticles in treating cyanobacterial biofilms, finding that cationized phytoglycogen nanoparticles can strongly inhibit and eradicate biofilms due to their strong electrostatic interactions with cyanobacterial cells. These antibacterial polysaccharide nanoparticles may provide a novel cost-effective and environment-friendly strategy for treating biofilm formation by a broad spectrum of bacteria.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Multidisciplinary Sciences
Bingfa Sun, Francis S. Willard, Dan Feng, Jorge Alsina-Fernandez, Qi Chen, Michal Vieth, Joseph D. Ho, Aaron D. Showalter, Cynthia Stutsman, Liyun Ding, Todd M. Suter, James D. Dunbar, John W. Carpenter, Faiz Ahmad Mohammed, Eitaro Aihara, Robert A. Brown, Ana B. Bueno, Paul J. Emmerson, Julie S. Moyers, Tong Sun Kobilka, Matthew P. Coghlan, Brian K. Kobilka, Kyle W. Sloop
Summary: Tirzepatide is a dual incretin receptor agonist that improves glucose control and body weight regulation in type 2 diabetes mellitus. Mechanistic pharmacology studies combined with cryogenic electron microscopy have provided insights into the structural basis and interactions of Tirzepatide with GIPR and GLP-1R.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Jorge Alves-Silva, Monica Zuzarte, Carlos Cavaleiro, Ligia Salgueiro
Summary: Fungal infections are prevalent with high morbidity and mortality rates, especially in patients with underlying health complications. Plant-based antifungal products show promise in mitigating these infections, and Lavandula multifida essential oil has been found to have strong inhibitory and disruptive effects on fungal biofilms. The oil significantly decreased biofilm mass and viability, and induced morphological alterations in fungal biofilms, making it a potential candidate for the development of effective antifungal products.
Review
Biochemistry & Molecular Biology
Elizabeth Goya-Jorge, Maria Elisa Jorge Rodriguez, Maite Sylla-Iyarreta Veitia, Rosa M. Giner
Summary: The aryl hydrocarbon receptor (AhR) is a crucial transcription factor in health and disease, particularly in cancer, immunology, inflammatory conditions, and aging. Flavonoids, the largest group of natural AhR ligands in the human diet, have complex modulatory effects on AhR that need further investigation to understand their potentially harmful and beneficial effects. Flavonoids exhibit tissue, organ, and species-specific activities on AhR, suggesting potential benefits in pharmacotherapy.
Article
Nutrition & Dietetics
Montana Camara, Rosa Maria Giner, Elena Gonzalez-Fandos, Esther Lopez-Garcia, Jordi Manes, Maria P. Portillo, Magdalena Rafecas, Laura Dominguez, Jose Alfredo Martinez
Summary: Food-Based Dietary Guidelines (FBDG) from different countries around the world share common principles but show significant differences in recommended amounts, reflecting diverse cultural and dietary preferences among nations.
Article
Chemistry, Applied
Elizabeth Goya-Jorge, Osmary Fernandez Exposito, Jose Manuel Herrero-Martinez, Ernesto F. Simo-Alfonso, Idelfonso Castaneda-Noa, Maria Elisa Jorge Rodriguez
Summary: This study analyzed the composition of the essential oil of Mosiera bullata for the first time, identifying nineteen components with 1,8-cineole and eugenol as the major compounds. A fingerprint of the volatile composition of Mosiera bullata leaves was proposed using GC/FID chromatograms, with chemometric methods ensuring the reliability of the chromatographic fingerprinting.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Batoul Rostom, Racha Karaky, Issam Kassab, Maite Sylla-Iyarreta Veitia
Summary: Natural and synthetic coumarins have been studied as effective drugs with multiple pharmacological activities, particularly in anti-inflammatory potential. However, there has been no major breakthrough in the development of therapeutic anti-inflammatory agents using coumarins. This review summarizes the relevant studies conducted in the last two decades and presents evidence for the anti-inflammatory mechanisms of coumarins, specifically targeting Toll-like receptors, JAK/STAT pathway, inflammasomes, MAPK pathway, NF-kappa B pathway, and TGF-beta/SMAD pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Elizabeth Goya-Jorge, Irma Gonza, Pauline Bondue, Caroline Douny, Bernard Taminiau, Georges Daube, Marie-Louise Scippo, Veronique Delcenserie
Summary: Functional symbiotic intestinal microbiota plays a crucial role in immune defense and xenobiotic metabolism. This study investigates the interaction between host and microbiota through the aryl hydrocarbon receptor (AhR). The results suggest that microbiota metabolic products can induce AhR transcriptional activity, with some short-chain fatty acids and biogenic amines identified as potential contributors. AhR activation serves as an important endpoint in studying gut microbiota.
Article
Nutrition & Dietetics
Carmen Rubio, Montana Camara, Rosa Maria Giner, Maria Jose Gonzalez-Munoz, Esther Lopez-Garcia, Francisco J. Morales, M. Victoria Moreno-Arribas, Maria P. Portillo, Elena Bethencourt
Summary: The consumption of energy drinks worldwide is increasing, along with concerns about potential health risks. This study assesses the exposure to caffeine, taurine, and D-glucuronolactone in energy drinks in different scenarios and consumer profiles, and characterizes the risks through the evaluation of intake levels and safety margins. The findings suggest the need for managing these risks and establishing consumption recommendations and restrictions.
Article
Biochemistry & Molecular Biology
Ameni Hadj Mohamed, Aline Pinon, Nathalie Lagarde, Elizabeth Goya Jorge, Hadley Mouhsine, Moncef Msaddek, Bertrand Liagre, Maite Sylla-Iyarreta Veitia
Summary: The diarylmethane scaffold has distinctive properties that are important in pharmaceutical, agrochemical, and material sciences. In this study, 33 novel diarylmethane molecules targeting colorectal cancer were designed and synthesized. These molecules showed high inhibition of cancer cell proliferation and low toxicity on normal cells, indicating their potential as anticancer agents.
Article
Virology
Margaux Navez, Celine Antoine, Fanny Laforet, Elizabeth Goya-Jorge, Caroline Douny, Marie-Louise Scippo, Marjorie Vermeersch, Jean-Noel Duprez, Georges Daube, Jacques Mainil, Bernard Taminiau, Veronique Delcenserie, Damien Thiry
Summary: Enterotoxigenic Escherichia coli (ETEC) strains causing post-weaning diarrhea in piglets can be effectively treated with bacteriophage therapy. In this study, four bacteriophages were isolated and one of them showed therapeutic potential in vivo against ETEC infection. Furthermore, this phage was found to replicate efficiently both in vitro and in vivo, demonstrating its safety on the piglet microbiota.
Article
Virology
Fanny Laforet, Celine Antoine, Sarah Lebrun, Irma Gonza, Elizabeth Goya-Jorge, Caroline Douny, Jean-Noel Duprez, Marie-Louise Scippo, Bernard Taminiau, Georges Daube, Abdoulaye Fall, Damien Thiry, Veronique Delcenserie
Summary: The effect of phage ULIP33 on the intestinal microbiota was assessed using in vitro model. Results showed that the phage did not have a significant impact on the colonic microbiota, suggesting its potential as an alternative treatment against antimicrobial resistance.
Article
Food Science & Technology
Elizabeth Goya-Jorge, Pauline Bondue, Irma Gonza, Fanny Laforet, Celine Antoine, Samiha Boutaleb, Caroline Douny, Marie-Louise Scippo, Jeoffrey Christyn de Ribaucourt, Fabienne Crahay, Veronique Delcenserie
Summary: Green kiwi (Actinidia deliciosa var. Hayward) has important nutritional attributes and has been traditionally used as a laxative. In this study, the colonic fermentation of a standardized green kiwifruit powder (Kiwi FFG) was investigated in vitro using intestinal microbial content from mildly constipated women. The results showed that the kiwifruit powder had a significant butyrogenic effect and increased butyrate-producing bacterial populations.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Celine Antoine, Fanny Laforet, Elizabeth Goya-Jorge, Irma Gonza, Sarah Lebrun, Caroline Douny, Jean-Noel Duprez, Abdoulaye Fall, Bernard Taminiau, Marie-Louise Scippo, Georges Daube, Damien Thiry, Veronique Delcenserie
Summary: This study evaluated the effectiveness of phage therapy against Escherichia coli K1 in the intestinal environment and its impact on the intestinal microbiota. The results showed that the phage was able to infect E. coli K1, but could not completely eliminate the bacterial load.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Arthur Lamouroux, Malaury Tournier, Debora Iaculli, Anne Caufriez, Olga M. Rusiecka, Charlotte Martin, Viviane Bes, Laureano E. Carpio, Yana Girardin, Remy Loris, Andreis Tabernilla, Filippo Molica, Rafael Gozalbes, Maria D. Mayan, Mathieu Vinken, Brenda R. Kwak, Steven Ballet
Summary: A series of macrocyclic peptidomimetics of Pannexin1 channels were developed and synthesized, showing better performance than the linear native peptides. Two compounds, SBL-PX1-42 and SBL-PX1-44, exhibited promising bidirectional inhibitory effects on the channel function. The introduction of triazole-based cross-links in the peptides enhanced helical content and stability. One of the peptides, SBL-PX1-206, efficiently reduced monocyte adhesion to activated endothelial cells, making it a potential candidate for in vivo investigations in animal models of cardiovascular inflammatory disease.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Elizabeth Goya-Jorge, Irma Gonza, Pauline Bondue, Germain Druart, Mohamed Al-Chihab, Samiha Boutaleb, Caroline Douny, Marie-Louise Scippo, Philippe Thonart, Veronique Delcenserie
Summary: Bacteriotherapy is a promising approach for the prevention and treatment of human diseases. This study explored the use of probiotic cocktails as an alternative multi-target therapy. Four three-strain probiotic mixtures were prepared and tested, and one formulation containing Bc. subtilis subsp. natto, Lv. brevis, and Lc. paracasei showed promising results in modulating the colonic microbiota.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Chemistry, Medicinal
Arthur Lamouroux, Malaury Tournier, Debora Iaculli, Anne Caufriez, Olga M. Rusiecka, Charlotte Martin, Viviane Bes, Laureano E. Carpio, Yana Girardin, Remy Loris, Andreis Tabernilla, Filippo Molica, Rafael Gozalbes, Maria D. Mayan, Mathieu Vinken, Brenda R. Kwak, Steven Ballet
Summary: A series of macrocyclic (stapled) peptidomimetics of 10Panx1 were developed and synthesized, which showed promising potential in inhibiting Panx1 channels and reducing cell adhesion in in vitro experiments.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)