Development of a minimal physiologically-based pharmacokinetic/pharmacodynamic model to characterize target cell depletion and cytokine release for T cell-redirecting bispecific agents in humans

Published 2020 View Full Article

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Title
Development of a minimal physiologically-based pharmacokinetic/pharmacodynamic model to characterize target cell depletion and cytokine release for T cell-redirecting bispecific agents in humans
Authors
Keywords
T cell redirecting bispecific antibodies (bsAbs), Blinatumomab, Minimal physiologically-based pharmacokinetic (mPBPK) model, Pharmacokinetic/pharmacodynamic (PK/PD) modeling, Cytokine release, Stepwise dosing regimen
Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 146, Issue -, Pages 105260
Publisher
Elsevier BV
Online
2020-02-11
DOI
10.1016/j.ejps.2020.105260

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