Review
Nutrition & Dietetics
Ricardo Araujo, Marta Borges-Canha, Pedro Pimentel-Nunes
Summary: Metabolic syndrome is a global epidemic characterized by metabolic dysfunctions and cardiovascular disease risk factors. The gut microbiota plays a crucial role in this syndrome, and therapeutic interventions such as probiotics and synbiotics show promise in correcting metabolic disturbances and restoring gut homeostasis.
Review
Nutrition & Dietetics
Sonia Croci, Lina Ilaras D'Apolito, Valeria Gasperi, Maria Valeria Catani, Isabella Savini
Summary: This passage discusses the relationship between metabolic syndrome and gut microbiota, indicating that dysbiosis may play a role in the pathogenesis of various chronic diseases; certain metabolites derived from microorganisms can trigger subclinical inflammatory processes related to MetS.
Article
Medicine, General & Internal
Oliwia Gawlik-Kotelnicka, Anna Skowronska, Aleksandra Margulska, Karolina H. Czarnecka-Chrebelska, Igor Loniewski, Karolina Skonieczna-Zydecka, Dominik Strzelecki
Summary: This study protocol aims to assess the effects of probiotic supplementation on symptoms of depression, metabolic parameters, inflammatory markers, and fecal microbiota in patients with depressive disorders. The trial may establish a safe and easy-to-use adjunctive treatment option for patients who are partially responsive to pharmacologic therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Chaiyavat Chaiyasut, Bhagavathi Sundaram Sivamaruthi, Narissara Lailerd, Sasithorn Sirilun, Suchanat Khongtan, Pranom Fukngoen, Sartjin Peerajan, Manee Saelee, Khontaros Chaiyasut, Periyanaina Kesika, Phakkharawat Sittiprapaporn
Summary: This study investigated the effects of supplementing a probiotic mixture (Lactobacillus paracasei HII01, Bifidobacterium breve, and Bifidobacterium longum) on intestinal permeability, lipid profile, obesity index, and metabolic biomarkers in elderly Thai subjects. The results showed that the supplementation of probiotics improved intestinal barrier function, increased high-density lipoprotein cholesterol levels, and improved obesity-related anthropometric biomarkers and short-chain fatty acid levels in human subjects.
Article
Dentistry, Oral Surgery & Medicine
Andre L. G. Moreira, Pedro H. F. Silva, Sergio L. Salvador, Karin H. Ishikawa, Graziele C. Ferreira, Jose E. Tanus-Santos, Marcia P. A. Mayer, Sergio L. S. de Souza, Flavia A. C. Furlaneto, Michel R. Messora
Summary: This study evaluated the systemic and local impact of probiotic therapy on rats with metabolic syndrome and periodontitis. The results showed that probiotics can reduce the severity of periodontitis, and modulate lipogenic genes and intestinal morphological and microbiological parameters in rats with metabolic syndrome.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Chemistry, Medicinal
Oliwia Gawlik-Kotelnicka, Dominik Strzelecki
Summary: Probiotics are shown to be effective in reducing depressive symptoms when used with antidepressants and may ameliorate some clinical components of metabolic diseases. However, standardized methodology regarding probiotics use in clinical trials is still lacking.
Article
Nutrition & Dietetics
Paolo Orlandoni, Nikolina Jukic Peladic, Angela Amoruso, Marco Pane, Mirko Di Rosa, Jennifer Vedruccio, Franco Santini
Summary: A double-blind, placebo-controlled study on geriatric patients undergoing home enteral nutrition (HEN) showed that Proxian(R) probiotic supplement did not significantly reduce infection incidence or modulate inflammation, but demonstrated potential in safety and ease of administration.
Article
Agriculture, Multidisciplinary
Juciane de Abreu Ribeiro Pereira, Maria de Fatima Piccolo Barcelos, Eduardo Valerio Villas Boas, Roberta Hilsdorf Piccoli, Janina de Sales Guilarducci, Rafaela Correa Pereira, Jose Rodrigo Pauli, Eric Batista Ferreira, Michel Cardoso de Angelis-Pereira, Dennys Esper Cintra
Summary: This study found that the combination of yacon flour and yogurt with two strains of probiotics had positive effects on metabolic parameters, inflammatory and insulin signaling proteins in diet-induced obese mice. The combination resulted in decreased body weight, fasting glucose, and triacylglycerol levels, as well as reduced fat accumulation. Additionally, it decreased inflammatory markers and improved insulin signaling. These findings suggest that the use of prebiotics and probiotics in food can counteract obesity-associated inflammation and improve insulin resistance in the short term.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Nutrition & Dietetics
Amir Hadi, Arman Arab, Saman Khalesi, Nahid Rafie, Marzieh Kafeshani, Maryam Kazemi
Summary: The supplementation with pro-/synbiotics may be beneficial in reducing total cholesterol levels in adults with MetS. However, there is no evidence supporting the effectiveness of pro-/synbiotics consumption on other anthropometric or metabolic outcomes of MetS. Further investigations with larger sample sizes are needed to confirm these findings.
CLINICAL NUTRITION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Giselle A. Silva, Andre L. G. Moreira, Pedro H. F. Silva, Sergio L. Salvador, Renato C. Casarin, Raphael M. Vicente, Graziele C. Ferreira, Jose E. Tanus-Santos, Flavia A. C. Furlaneto, Michel R. Messora
Summary: The study found that the use of B. lactis HN019 in rats can reduce the severity of periodontitis while regulating systemic metabolic and immunoinflammatory parameters. The use of probiotics has a beneficial effect on dyslipidemia parameters in rats with or without metabolic syndrome.
JOURNAL OF PERIODONTOLOGY
(2022)
Review
Medicine, Research & Experimental
Marta Jimenez-Muro, Laura Soriano-Romani, Gonzalo Mora, Diego Ricciardelli, Juan Antonio Nieto
Summary: The relationship between obesity and osteoarthritis (OA) development has traditionally been explained as a result of excessive joint effort due to overweight. However, in the past two decades, a metabolic OA has been suggested, which involves metabolic syndrome and various molecular mechanisms. Metabolic syndrome leads to the release of inflammatory cytokines, particularly increased adipokines in obesity, causing chronic low-grade inflammation that disrupts joint homeostasis. Microbiota dysbiosis exacerbates chronic inflammation or mediates metabolic disorders through endotoxemia, leading to joint inflammation and cartilage degradation, ultimately contributing to the development of OA. Insulin resistance associated with type 2 diabetes also contributes to OA development. Notably, there are similarities between the food patterns associated with metabolic syndrome and those associated with OA development, further supporting the idea of a molecular mechanism linking metabolic syndrome and OA. This review highlights the relationship between metabolic syndrome and OA, exploring the shared molecular mechanisms and dietary patterns that promote or prevent both pathologies.
Article
Neurosciences
Thomas S. Webberley, Giulia Masetti, Ryan J. Bevan, Joshua Kerry-Smith, Alison A. Jack, Daryn R. Michael, Sophie Thomas, Maria Glymenaki, Jia Li, Julie A. K. McDonald, Daniel John, James E. Morgan, Julian R. Marchesi, Mark A. Good, Sue F. Plummer, Timothy R. Hughes
Summary: Supplementation with Lab4b probiotic consortium may have positive effects on the cognitive and pathological progression of Alzheimer's disease, as well as improving metabolic status.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Alicia Rodriguez-Pasten, Nury Perez-Hernandez, Javier Anorve-Morga, Ruben Jimenez-Alvarado, Raquel Carino-Cortes, Teresa Sosa-Lozada, Eduardo Fernandez-Martinez
Summary: Metabolic syndrome and hepatogastrointestinal diseases are influenced by lifestyle and diet, and their development is closely related to dysbiosis. Prebiotics, probiotics, and symbiotic complexes play a crucial role in regulating the immune system and carbohydrate and lipid metabolism, as well as improving dysbiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Jose Riezu-Boj, Miguel Barajas, Tania Perez-Sanchez, Maria J. Pajares, Miriam Arana, Fermin Milagro, Raquel Urtasun
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, and modulating the gut microbiota may be a promising therapeutic approach. This study found that the Lactiplantibacillus plantarum strain DSM20174 (L.p. DSM20174) can prevent NAFLD progression, improve metabolic balance, and reduce inflammation.
Article
Peripheral Vascular Disease
Edoardo Casiglia, Valerie Tikhonoff, Agostino Virdis, Guido Grassi, Fabio Angeli, Carlo M. Barbagallo, Michele Bombelli, Arrigo F. G. Cicero, Massimo Cirillo, Pietro Cirillo, Raffaella Dell'Oro, Lanfranco D'elia, Giovambattista Desideri, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Iaccarino, Luciano Lippa, Francesca Mallamaci, Stefano Masi, Alessandro Maloberti, Maria Masulli, Alberto Mazza, Alessandro Mengozzi, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Roberto Pontremoli, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Massimo Salvetti, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Francesca Viazzi, Massimo Volpe, Claudio Borghi
Summary: In the URRAH study, we identified the cut-off value for the ratio of serum uric acid (SUA) to serum creatinine (sCr) that can predict cardiovascular events. We found that having SUA/sCr > 5.35 is an independent cardiovascular risk indicator for both men and women.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Paolo Palatini, Agostino Virdis, Stefano Masi, Alessandro Mengozzi, Edoardo Casiglia, Valerie Tikhonoff, Arrigo F. G. Cicero, Andrea Ungar, Gianfranco Parati, Giulia Rivasi, Massimo Salvetti, Carlo M. Barbagallo, Michele Bombelli, Raffaella Dell'Oro, Berardino Bruno, Luciano Lippa, Lanfranco D'Elia, Maria Masulli, Paolo Verdecchia, Gianpaolo Reboldi, Fabio Angeli, Francesca Mallamaci, Massimo Cirillo, Marcello Rattazzi, Pietro Cirillo, Loreto Gesualdo, Alberto Mazza, Cristina Giannattasio, Alessandro Maloberti, Massimo Volpe, Giuliano Tocci, Guido Iaccarino, Pietro Nazzaro, Ferruccio Galletti, Claudio Ferri, Giovambattista Desideri, Francesca Viazzi, Roberto Pontremoli, Maria Lorenza Muiesan, Guido Grassi, Claudio Borghi
Summary: This study investigates the association between very high HDL-cholesterol levels and cardiovascular mortality (CVM), and whether this association is influenced by hyperuricemia. The results show a J-shaped association between high HDL-cholesterol levels and CVM in women, but not in men. Additionally, the risk of CVM related to high HDL-cholesterol is increased in women with hyperuricemia.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Nutrition & Dietetics
Arrigo F. G. Cicero, Federica Fogacci, Sergio D'Addato, Elisa Grandi, Elisabetta Rizzoli, Claudio Borghi
Summary: Although coffee has been linked to various cardiovascular benefits, its impact on blood pressure remains unclear. This study found that moderate coffee consumption was associated with lower systolic blood pressure, while heavy coffee consumption was associated with higher levels of systolic blood pressure.
Review
Medicine, General & Internal
Cormac Kennedy, Peter Hayes, Sulafa Salama, Martina Hennessy, Federica Fogacci
Summary: This study found that the GLP-1 RA drug semaglutide can significantly reduce weight and improve blood pressure in non-diabetic patients. The analysis included 6 RCT trials with a total of 4744 participants, and the results showed that the participants had normal blood pressure at baseline. After semaglutide treatment, the mean reduction in systolic blood pressure was 4.83 mmHg, and the mean reduction in diastolic blood pressure was 2.45 mmHg.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Serkan Bolat, Gozde Erturk Zararsiz, Kuebra Dogan, Necla Kochan, Serra I. Yerlitas, Ahu Cephe, Gokmen Zararsiz, Arrigo F. G. Cicero
Summary: This study aimed to evaluate the concordance of LDL-C-estimating equations with direct enzymatic measurement in diabetic and prediabetic populations. It was found that all equations had lower concordance with direct enzymatic measurement in diabetic and prediabetic groups, with the Martin-Hopkins extended equation performing the best. Additionally, direct assay methods can be used at low values of the non-HDL-C/TG ratio (<2.4) as the performance of the equations in LDL-C estimation decreases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Alessia Silla, Federica Fogacci, Angela Punzo, Silvana Hrelia, Patrizia Simoni, Cristiana Caliceti, Arrigo F. G. Cicero
Summary: Atherosclerosis and ASCVD can be improved by reducing the levels of LDL cholesterol. A new injectable antibody targeting PCSK9, called Evolocumab, has been approved for better lipid control in high-risk individuals. The use of Evolocumab has shown significant improvement in blood pressure and arterial pulse wave velocity, as well as a decrease in H2O2 production.
Article
Nutrition & Dietetics
Arrigo F. G. Cicero, Federica Fogacci, Marina Giovannini, Elisabetta Rizzoli, Elisa Grandi, Sergio D'Addato, Claudio Borghi
Summary: The DESCO study found that dietary supplementation with plant sterols significantly improved the lipid profile, particularly the levels of total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B-100. Compared to placebo, the intake of plant sterols also resulted in greater reductions in lipid levels, with better efficacy observed in individuals following a Mediterranean dietary pattern.
Review
Medicine, General & Internal
Francesco Perone, Marco Bernardi, Alban Redheuil, Dario Mafrica, Edoardo Conte, Luigi Spadafora, Fiona Ecarnot, Lale Tokgozoglu, Carlos G. Santos-Gallego, Sergio Emanuel Kaiser, Federica Fogacci, Annabelle Sabouret, Deepak L. Bhatt, Francesco Paneni, Maciej Banach, Raul Santos, Giuseppe Biondi Zoccai, Kausik K. Ray, Pierre Sabouret
Summary: Optimal risk assessment for primary prevention is challenging and there are major discrepancies between guidelines and practice. Cardiovascular imaging plays a crucial role in categorizing individuals and enabling precise therapeutic strategies. Further research is needed to define individual residual risk and intensify treatment in high-risk subgroups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Giovanna Gallo, Riccardo Sarzani, Arrigo Francesco Giuseppe Cicero, Stefano Genovese, Matteo Pirro, Luca Gallelli, Andrea Faggiano, Massimo Volpe
Summary: Current cardiovascular disease prevention strategies focus on managing individual cardiovascular risk profiles, often requiring patients to take multiple drugs. Single pill fixed dose combinations can improve blood pressure and cholesterol control compared to separate drug administration, due to better adherence and simplicity. This paper discusses the use of the Rosuvastatin-Amlodipine combination for managing hypertension/hypercholesterolemia and emphasizes the importance of early and effective cardiovascular risk management.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2023)
Article
Medicine, General & Internal
Mahsa Mohajeri, Reza Mohajery, Arrigo F. G. Cicero
Summary: This study investigated the association between adherence to the Mediterranean diet and serum inflammatory factors, total antioxidant capacity, appetite, and symptoms of COVID-19 patients. The results showed that patients who adhered more to the Mediterranean diet had milder symptoms and lower levels of serum inflammatory factors. Therefore, clinical trials are suggested to confirm the effectiveness of the Mediterranean diet.
MEDICINA-LITHUANIA
(2023)
Review
Endocrinology & Metabolism
Federica Fogacci, Claudio Borghi, Sergio Davinelli, Giovanni Scapagnini, Arrigo F. G. Cicero
Summary: The purpose of this study was to evaluate the effect of different anti-oestrogen therapy on plasma Lp(a) level in postmenopausal women. The results showed that anti-oestrogen therapy significantly reduced Lp(a) levels in women.
Review
Peripheral Vascular Disease
Alessandro Maloberti, Alessandro Mengozzi, Elisa Russo, Arrigo Francesco Giuseppe Cicero, Fabio Angeli, Enrico Agabiti Rosei, Carlo Maria Barbagallo, Bruno Bernardino, Michele Bombelli, Federica Cappelli, Edoardo Casiglia, Rosario Cianci, Michele Ciccarelli, Massimo Cirillo, Pietro Cirillo, Giovambattista Desideri, Lanfranco D'Elia, Raffaella Dell'Oro, Rita Facchetti, Claudio Ferri, Ferruccio Galletti, Cristina Giannattasio, Loreto Gesualdo, Guido Iaccarino, Luciano Lippa, Francesca Mallamaci, Stefano Masi, Maria Masulli, Alberto Mazza, Maria Lorenza Muiesan, Pietro Nazzaro, Gianfranco Parati, Paolo Palatini, Paolo Pauletto, Roberto Pontremoli, Nicola Riccardo Pugliese, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Francesca Viazzi, Massimo Volpe, Agostino Virdis, Guido Grassi, Claudio Borghi, Italian Soc Hypertension SIIA
Summary: The relationship between serum uric acid and cardiovascular diseases, kidney function, and metabolic syndrome has been studied extensively. However, there are still unanswered questions, such as determining the optimal cutoff for cardiovascular risk, the need for adjustments of uric acid values for kidney function, and the precise role of uric acid in metabolic syndrome.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2023)
Review
Biochemistry & Molecular Biology
Federica Fogacci, Valentina Di Micoli, Ashot Avagimyan, Marina Giovannini, Egidio Imbalzano, Arrigo F. G. Cicero
Summary: This review aims to discuss the best strategy for utilizing molecular biology techniques to examine the genetic role of Lp(a) and its significance in clinical research and practice. The diversity in size of apo(a) is primarily caused by copy number variations in the KIV2 domains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)