Article
Materials Science, Multidisciplinary
Ipshita Menon, Maryam Zaroudi, Yuanzhe Zhang, Elizabeth Aisenbrey, Liwei Hui
Summary: Lipid nanoparticles have promising applications as non-viral vectors for targeted drug and gene delivery. This review focuses on the techniques to fabricate active targeting lipid nanoparticles, including one-pot assembly and post-insertion functionalization. The advantages, restrictions, and challenges in formulation screening and clinical translation are discussed.
MATERIALS TODAY ADVANCES
(2022)
Article
Oncology
Mingrong Cheng, Dejian Dai
Summary: By grafting folate onto biotin-modified chitosan, the targeting ability for liver cancer was optimized, leading to increased drug concentration in liver cancer tissue, inhibition of proliferation and migration of liver cancer cells, and alleviation of toxic side effects caused by 5-FU.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ming Wu, Qizhi Wang, Sai Chen, Zhanwei Zhou, Jing Li, Honghao Sun, Jiali Liu, Guangji Wang, Fang Zhou, Minjie Sun
Summary: This study investigated the dual inhibition of metabolic plasticity in breast cancer cells using Lip@GOx&Tel, which targeted and inhibited two nutrient supply mechanisms. This led to a reduction in ATP production and biosynthesis precursors necessary for tumor growth, resulting in anti-tumor effects. Additionally, Lip@GOx&Tel disrupted redox homeostasis, further enhancing the therapeutic effect. The study also addressed the limitation of combining protein drugs and small molecule drugs in vivo by using liposome nanoparticles. Overall, this work provides a new perspective in nanomedicine for metabolic intervention in diseases.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Jiawei Du, Yong Shao, Yue Hu, Yiwen Chen, Jiehui Cang, Xin Chen, Wenqin Pei, Fengqin Miao, Yuqing Shen, Mohd Muddassir, Ying Zhang, Jianqiong Zhang, Gaojun Teng
Summary: The study identified the overexpression of TWF1 gene in brain metastatic breast cancer cells, which was associated with PTX resistance. A liposome-based drug delivery system with BRBP1 peptide modification was developed to enhance PTX sensitivity and targeting of brain metastases. This system effectively crossed the BBB, accumulated in brain metastases, and inhibited TWF1 gene expression, leading to proliferation inhibition, cell cycle arrest, and apoptosis induction, ultimately inhibiting the formation and growth of brain metastases.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Lan Yang, Yongshun Zhang, Yu Zhang, Yani Xu, Yuai Li, Zhigiang Xie, Hairui Wang, Yunzhu Lin, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: This study demonstrates a system for treating triple-negative breast cancer by utilizing the tumor-targeting capabilities of macrophages. By loading doxorubicin-carrying liposomes on the surfaces of macrophages, the system significantly enhances drug accumulation at tumor sites, penetrates deeper into tumor tissue, and enhances the anti-tumor immune response, leading to improved survival rates in mice.
Article
Biochemistry & Molecular Biology
Ru Li, Yao Peng, Yanchi Pu, Yi Zhao, Ruifang Nie, Li Guo, Yong Wu
Summary: The study synthesized a dual-targeting liposome covalently modified with fructose and biotin, showing strong targeting ability and potential for breast cancer treatment through cellular uptake and in vivo imaging experiments.
JOURNAL OF LIPOSOME RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Laila Jaragh-Alhadad, Mayada Samir, Terri J. Harford, Sadashiva Karnik
Summary: Cancer is a significant cause of death worldwide, and current chemotherapy treatments lack specificity in targeting cancer cells. Researchers are exploring the use of LDL particles as drug carriers to minimize side effects on healthy tissues. The study shows that encapsulating anticancer agents in LDL particles effectively reduces cell proliferation and decreases tubulin expression in cancer cells.
Review
Biotechnology & Applied Microbiology
Pengzhi Shi, Zhangrong Cheng, Kangcheng Zhao, Yuhang Chen, Anran Zhang, Weikang Gan, Yukun Zhang
Summary: Osteosarcoma, the most common bone tumor, has a significant impact on people's lives and economic burden. Conventional chemotherapy drugs have limited effectiveness and severe side effects. Nanocarrier-based drug delivery systems with ligand modifications can enhance drug utilization and reduce adverse effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Maximilian Regenold, Kan Kaneko, Xuehan Wang, H. Benson Peng, James C. Evans, Pauric Bannigan, Christine Allen
Summary: Triggered drug delivery strategies, such as thermosensitive liposomes, have shown improved targetability for chemotherapeutics. However, most studies have focused on doxorubicin encapsulation, while other drugs could also benefit from this targeted delivery approach.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biophysics
Lama A. Helmy, Mohammed Abdel-Halim, Raghda Hassan, Aya Sebak, Haithem A. M. Farghali, Samar Mansour, Salma N. Tammam
Summary: The study examines the suitability of folic acid (FA) as a nanoparticle (NP) targeting ligand in breast cancer. Results suggest that the overexpression of the folate receptor (FR) in cancer cells may lead to negative effects on breast tissue, raising questions about the effectiveness of FA in targeting cancer cells. The research highlights the importance of considering the activity of ligands beyond just targeting in NP active targeting strategies.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Madhu Sharma, Naresh Mittapelly, Venkatesh Teja Banala, Sandeep Urandur, Shalini Gautam, Disha Marwaha, Nikhil Rai, Neha Singh, Ashutosh Gupta, Kalyan Mitra, Prabhat Ranjan Mishra
Summary: HR+/HER2- metastatic breast cancer is a common and dangerous condition in women. A novel MN system using HA-PVA-PVP microneedle array is developed to deliver RB for breast cancer treatment, reducing toxicity and improving efficacy.
Article
Materials Science, Multidisciplinary
Yibin Yu, Chong Huang, Fen Chen, Weisan Pan, Ling Zhang
Summary: Integration of diagnostic and therapeutic modalities into a single nanoplatform (HPCT nanomicelles) for breast cancer was achieved in this study. The nanomicelles comprised hyaluronan-b-poly(ecaprolactone) (HA-PCL), curcumin (Cur), and tocopheryl polyethylene glycol succinate (TPGS). Efficient drug loading, stability, and hyaluronidase-sensitive release were observed in the HPCT nanomicelles. In vivo SPECT/CT imaging confirmed the active targeting ability of the HAbased nanomicelles to breast cancer, while pharmacodynamic studies showed desirable anti-tumor efficacy with good biosafety. The 99mTc-HPCT nanomicelles, integrating imaging and therapeutic modalities, have great potential as an all-in-one theranostic nanoplatform for breast cancer.
MATERIALS & DESIGN
(2023)
Article
Pharmacology & Pharmacy
Zimiao Luo, Sunyi Wu, Jianfen Zhou, Weixia Xu, Qianzhu Xu, Linwei Lu, Cao Xie, Yu Liu, Weiyue Lu
Summary: Brain metastasis is a common and serious complication of breast cancer, especially in triple-negative breast cancer (TNBC). This study develops a Y-shaped peptide pVAP-decorated platelet-hybrid liposome drug delivery system to achieve targeted drug delivery for the treatment of brain metastasis from TNBC. The results show that this delivery platform significantly improves drug accumulation and exhibits superior inhibition of brain metastasis compared to the free drug. This work provides a promising prospect for the comprehensive treatment of brain metastasis in TNBC.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Qijun Liu, Lin Zhou, Runxin Lu, Chunyan Yang, Siqi Wang, Li Hai, Yong Wu
Summary: In this study, multi-targeting liposomes based on glucose and biotin were constructed for the first time, showing promising efficacy in targeting glioma. The results indicated that the multi-targeting liposomes had satisfactory glioma-targeting ability in vitro and could be a potential formulation for glioma treatment, consistent with the in vivo imaging results.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Anupriya Bandyopadhyay, Tuyelee Das, Samapika Nandy, Synudeen Sahib, Subham Preetam, Abilash Valsala Gopalakrishnan, Abhijit Dey
Summary: In the past decades, the applications of nanomedicines in cancer theranostics have been extensively studied. However, the major drawbacks of nanomedicine are decreased specificity and poor targeting efficiency. Ligand decorated nanocarrier-mediated targeted drug delivery system can overcome these limitations and achieve effective targeting. This article summarizes the features and potential of nanocarrier-mediated ligand-based active therapy as a promising approach for cancer treatment.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qiming Yue, Yi Zhao, Baohou Sun, Li Hai, Li Guo, Yong Wu
CHINESE JOURNAL OF CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Yi Zhao, Xiaolong Li, Hong Liu, Yongguo Yu, Li Hai, Li Guo, Yong Wu
Article
Chemistry, Organic
Qiming Yue, Yi Zhao, Li Hai, Tao Zhang, Li Guo, Yong Wu
Article
Environmental Sciences
Chuanren Duan, Yamin Cui, Yi Zhao, Jun Zhai, Baoyun Zhang, Kun Zhang, Da Sun, Hang Chen
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2016)
Article
Biochemistry & Molecular Biology
Yaoling Wang, Qiming Yue, Yi Zhao, Shubing Qiu, Yao Peng, Jue Li, Tao Zhang, Li Hai, Li Guo, Yong Wu
Article
Chemistry, Medicinal
Shubing Qiu, Yi Zhao, Sha Liu, Xiaocen Li, Li Guo, Li Hai, Yong Wu
LETTERS IN DRUG DESIGN & DISCOVERY
(2017)
Article
Pharmacology & Pharmacy
Qiming Yue, Yao Peng, Yi Zhao, Runxin Lu, Qiuyi Fu, Yang Chen, Yang Yang, Li Hai, Li Guo, Yong Wu
Article
Nanoscience & Nanotechnology
Linhui Wang, Yi Zhao, Runxin Lu, Yao Peng, Li Guo, Li Hai, Mei Guan, Yong Wu
Article
Biochemistry & Molecular Biology
Yao Peng, Yi Zhao, Yang Chen, Zhongzhen Yang, Li Zhang, Wenjiao Xiao, Jincheng Yang, Li Guo, Yong Wu
BIOORGANIC & MEDICINAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Wenjiao Xiao, Qiuyi Fu, Yi Zhao, Li Zhang, Qiming Yue, Li Hai, Li Guo, Yong Wu
CHEMISTRY AND PHYSICS OF LIPIDS
(2019)
Article
Biochemistry & Molecular Biology
Ze Zhao, Changqing Chen, Changwei Xie, Yi Zhao
CHEMISTRY AND PHYSICS OF LIPIDS
(2020)
Article
Biochemistry & Molecular Biology
Yang Yang, Ze Zhao, Changwei Xie, Yi Zhao
CHEMISTRY AND PHYSICS OF LIPIDS
(2020)
Article
Chemistry, Medicinal
Yi Zhao, Ze Zhao, Yamin Cui, Xing Chen, Changqing Chen, Changwei Xie, Bo Qin, Yang Yang
Summary: A novel combretastatin A-4 derivative (CA4D-SS-Glu) was designed in this study, with improved physicochemical properties and blood-brain barrier penetration ability, along with reduction-triggered drug release and efficient antiproliferative activity against glioma. This novel conjugate provides a promising new approach for the treatment of glioma.
DRUG DEVELOPMENT RESEARCH
(2021)
Article
Chemistry, Medicinal
Yi Zhao, Yao Peng, Zhongzhen Yang, Jiaqi Lu, Ru Li, Yuesen Shi, Yaxin Du, Ze Zhao, Li Hai, Yong Wu
Summary: In this study, novel cascadetargeted liposomes (Lip-TPGS) were designed and prepared for synergistic treatment of glioma. These liposomes could intelligently deliver redox-sensitive doxorubicin prodrugs and a chemotherapeutic sensitizer, providing a promising drug delivery system with potential advantages in inhibiting proliferation, promoting apoptosis, inducing mitochondria dysfunction, inhibiting migration and invasion, prolonging survival time, and reducing toxicity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
