Article
Immunology
Dylan Krajewski, Debayon Paul, Shujun Ge, Evan Jellison, Joel S. Pachter
Summary: In experimental autoimmune encephalomyelitis (EAE), claudin-5 (CLN-5) was found on leukocytes in the blood and central nervous system (CNS), potentially facilitating leukocyte transendothelial migration (TEM) across the blood-brain barrier. Flow cytometry analysis showed CLN-5(+) populations among various leukocyte subtypes, with higher levels in CNS tissue than in blood, suggesting preferential access to the CNS. This novel mechanism may guide leukocytes to sites for diapedesis across the BBB.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Lisa Welzel, David H. Bergin, Alina Schidlitzki, Friederike Twele, Marie Johne, Pavel Klein, Wolfgang Loescher
Summary: The authors proposed a novel approach involving multiple targets and networks, combining drugs to prevent the onset of epilepsy, and provided initial evidence of its effectiveness.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Madeeha H. Sheikh, Mariella Errede, Antonio D'Amati, Noorafza Q. Khan, Silvia Fanti, Rodrigo A. Loiola, Simon McArthur, Gareth S. D. Purvis, Caroline E. O'Riordan, Davide Ferorelli, Alessandro Dell'Erba, Julius Kieswich, Chis Reutelingsperger, Eugenio Maiorano, Magdi Yaqoob, Christoph Thiemermann, Andrea Baragetti, Alberico Luigi Catapano, Giuseppe Danilo Norata, Federica Marelli-Berg, Daniela Virgintino, Egle Solito
Summary: Mounting evidence suggests a link between metabolic disease and neurovascular disorders and cognitive decline. This study used mouse models and post-mortem brains of T2DM patients to show that metabolic disease damages the blood-brain barrier (BBB), leading to increased leukocyte extravasation and neuroinflammation. Therapeutic interventions such as pharmacological treatment and dietary changes were found to reduce BBB damage.
Review
Biochemistry & Molecular Biology
Jeanette A. M. Maier, Laura Locatelli, Giorgia Fedele, Alessandra Cazzaniga, Andre Mazur
Summary: Magnesium plays a crucial role in regulating metabolism and maintaining tissue homeostasis, including the brain. It is essential for nerve signal transmission and protecting the blood-brain barrier. Deficiency in magnesium can lead to systemic low-grade inflammation, which is common in various diseases, particularly neurodegenerative disorders. This review provides evidence linking magnesium imbalance to multiple sclerosis, Alzheimer's, and Parkinson's diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Roberta Lattanzi, Rossella Miele
Summary: Prokineticins are a new class of peptides that play a crucial role in neuroinflammatory processes, regulating neuronal-glial interactions and T cell function. PK2 and PKRs are upregulated during inflammation, influencing inflammatory responses and directing T cells towards a pro-inflammatory phenotype.
Article
Plant Sciences
Hairong Zhao, Mei Wang, Xi Huang, Xiumei Wu, Huai Xiao, Fanmao Jin, Jiaming Lv, Jidong Cheng, Yu Zhao, Chenggui Zhang
Summary: Wasp venom exhibits potential neuroprotective effects on acute ischaemic stroke (AIS) in rats, improving neurological impairment, promoting blood flow recovery, reducing infarct volume, and regulating blood-brain barrier permeability. The venom also inhibits inflammation and apoptosis, and modulates angiogenesis factors in the brain.
PHARMACEUTICAL BIOLOGY
(2022)
Review
Neurosciences
Ghaith A. Bahadar, Zahoor A. Shah
Summary: Diabetes Mellitus (DM) is a major risk factor for stroke-related disabilities, especially in cases of intracerebral hemorrhage (ICH). While previous studies have focused on the impact of DM on ischemic stroke, recent attention has shifted to its effects on ICH, including oxidative damage, Reactive Oxygen Species (ROS) production, and neuroinflammatory processes in DM-ICH patients.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2021)
Article
Biochemistry & Molecular Biology
Zhengzheng Ruan, Dongdong Zhang, Ruixue Huang, Wei Sun, Liyan Hou, Jie Zhao, Qingshan Wang
Summary: Chronic neuroinflammation damages dopaminergic neurons in a rotenone-induced mouse PD model through blood-brain barrier dysfunction mediated by microglial MMP-2/-9 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yu-Lian Zeng, Yang Du, Xin-Xin Xu, Ya-Jun Wang, Sai-Xi Yu, Ting Liu, Shiyuan Luo, Xiao-Wei Xiang, Wei Liu, Yu-Chen Chen, Hongjun Huang, Hai Gao, Yuhui Shen, Yan Luo, Chengrong Bao, Yan-Jun Liu
Summary: The blood-brain barrier (BBB) is a physical structure that maintains CNS homeostasis and its disruption is involved in neurodegenerative diseases. A microfluidic BBB chip model was developed to mimic the physiological and pathological states. Glial cells in the functional BBB showed activation in response to stimulation, but exhibited blunted responses in a pathological extracellular microenvironment. The BBB-on-a-chip can help study cell-cell interactions in neurodegenerative diseases and evaluate drug efficacy.
Article
Medicine, Research & Experimental
Katarzyna Potyrak, Benita Wiatrak, Edward Krzyzak, L. Lukasz Szczukowski, Piotr Swiatek, Adam Szelag
Summary: Alzheimer's disease remains a serious disorder with no effective therapy. However, certain compounds show potential for beneficial effects on damaged neuronal cells and are capable of crossing the blood-brain barrier.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Scott R. Burks, Cymon N. Kersch, Jaclyn A. Witko, Michael A. Pagel, Maggie Sundby, Leslie L. Muldoon, Edward A. Neuwelt, Joseph A. Frank
Summary: Intracarotid arterial hyperosmolar mannitol (ICAHM) is effective and safe for treating central nervous system malignancies by disrupting the blood-brain barrier, but it can induce a transient neuroinflammatory response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Orianne Constant, Ghizlane Maarifi, Fabien P. Blanchet, Philippe van de Perre, Yannick Simonin, Sara Salinas
Summary: This review highlights the important contribution of dendritic cells in the development and consequences of viral brain infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Danny Lam, Anisha Javadekar, Nirav Patil, Marina Yu, Longshun Li, Dhariyat M. Menendez, Anirban Sen Gupta, Jeffrey R. Capadona, Andrew J. Shoffstall
Summary: Intracortical microelectrodes induce vascular injury upon insertion into the cortex, leading to blood-brain barrier damage and increased immune and inflammatory responses. Blood proteins, including fibrinogen and von Willebrand Factor, as well as platelets, persist at the microelectrode interface, promoting neuroinflammation and declining recording performance.
ACTA BIOMATERIALIA
(2023)
Article
Neurosciences
Junyu Shi, Yifan Xiao, Na Zhang, Mengya Jiao, Xuhuan Tang, Chan Dai, Chenchen Wang, Yong Xu, Zheng Tan, Feili Gong, Fang Zheng
Summary: This study found that HMGB1 produced by astrocytes plays a role in exacerbating experimental autoimmune encephalomyelitis (EAE). It influences immune cell infiltration in the central nervous system by regulating the functions of brain microvascular endothelial cells (BMECs).
NEUROSCIENCE BULLETIN
(2022)
Article
Clinical Neurology
Alexis M. Crockett, Sean K. Ryan, Adriana Hernandez Vasquez, Caroline Canning, Nickole Kanyuch, Hania Kebir, Guadalupe Ceja, James Gesualdi, Elaine Zackai, Donna McDonald-McGinn, Angela Viaene, Richa Kapoor, Nail Benallegue, Raquel Gur, Stewart A. Anderson, Jorge Alvarez
Summary: Neuroimmune dysregulation is implicated in neuropsychiatric disorders, including schizophrenia. Research found compromised vascular phenotype in patients with 22q11.2 deletion syndrome, leading to compromised immune privilege and potentially increased risk of neuropsychiatric disease.
Article
Clinical Neurology
Theodor Rueber, Bastian David, Guido Luechters, Robert D. Nass, Alon Friedman, Rainer Surges, Tony Stoecker, Bernd Weber, Ralf Deichmann, Gottfried Schlaug, Elke Hattingen, Christian E. Elger
Article
Agriculture, Dairy & Animal Science
K. Schuh, H. Sadri, S. Haeussler, L. A. Webb, C. Urh, M. Wagner, C. Koch, J. Frahm, S. Daenicke, G. Dusel, H. Sauerwein
Article
Clinical Neurology
Robert D. Nass, Lukas J. Motloch, Vera Paar, Michael Lichtenauer, Jan Baumann, Berndt Zur, Uta C. Hoppe, Stefan Holdenrieder, Christian E. Elger, Rainer Surges
Article
Clinical Neurology
Robert Daniel Nass, Niels Hansen, Carlos Quesada, Theodor Rueber, Cornelia Kornblumb, Gabor Zsurka, Philipp Herrnann, Albert Becker, Florian Gaertner, Elke Hattingen, Wolfgang Block, Eike Steidl, Christian E. Elger, Rainer Surges, Wolfram S. Kunz
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2019)
Review
Clinical Neurology
Robert D. Nass, Kevin G. Hampel, Christian E. Elger, Rainer Surges
FRONTIERS IN NEUROLOGY
(2019)
Article
Behavioral Sciences
Yannic Titgemeyer, Rainer Surges, Dirk-Matthias Altenmueller, Susanne Fauser, Albrecht Kunze, Michael Lanz, Michael P. Malter, Robert Daniel Nass, Felix von Podewils, Jan Remi, Sarah von Spiczak, Adam Strzelczyk, Roann Munoz Ramos, Ekaterina Kutafina, Stephan Michael Jonas
EPILEPSY & BEHAVIOR
(2020)
Review
Clinical Neurology
Max Christian Pensel, Robert Daniel Nass, Erik Tauboll, Dag Aurlien, Rainer Surges
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2020)
Article
Clinical Neurology
Juri-Alexander Witt, Robert D. Nass, Tobias Baumgartner, Randi von Wrede, Christian E. Elger, Rainer Surges, Christoph Helmstaedter
Article
Clinical Neurology
Robert Daniel Nass, Katja Akguen, Christian Elger, Heinz Reichmann, Marcus Wagner, Rainer Surges, Tjalf Ziemssen
Summary: This study investigated changes in biomarkers following seizures and found significant cerebral stress and inflammatory responses in some cases.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Clinical Neurology
Robert Daniel Nass, Julia Taube, Tobias Bauer, Theodor Ruber, Rainer Surges, Christoph Helmstaedter
Summary: The study conducted a long-term follow-up of epilepsy patients, finding that although some patients showed improvement after discharge from the intensive care unit, the severity of the disease remained high during follow-up. Most patients experienced varying degrees of impairment in functional outcomes, leading to a decline in independence and cognitive function.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Amirhossein Jahanbekam, Jan Baumann, Robert D. Nass, Christian Bauckhage, Holger Hill, Christian E. Elger, Rainer Surges
Summary: Algorithms based on ECG features alone show promise in automatic detection of seizures, but their performance may vary depending on the circumstances under which they were developed and the selection of data sets. These algorithms may not generalize well to unseen patient groups behaving in different conditions.
Article
Clinical Neurology
Robert D. Nass, Berndt Zur, Christian E. Elger, Stefan Holdenrieder, Rainer Surges
Article
Clinical Neurology
Robert D. Nass, Sina Meiling, Rene P. Andrie, Christian E. Elger, Rainer Surges