Review
Neurosciences
Jianjun Xu, Etsuko Minobe, Masaki Kameyama
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor dysfunction, and its exact causes are still unknown. Risk factors for PD include aging, genetic mutations, environmental factors, and gender. Endoplasmic reticulum stress, excessive reactive oxygen species production, and impaired autophagy have been linked to neuronal death in the substantia nigra pars compacta in PD. Dysregulation of Ca2+ handling may mediate risk factor-related PD pathogenesis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kongdong Li, Chuanzhi Guo, Jiacheng Ruan, Bo Ning, Chris Kong-Chu Wong, Haifeng Shi, Jie Gu
Summary: Cadmium (Cd2+) exposure-induced cytotoxicity and renal injury can be protected against by activating the calcium-sensing receptor (CaSR) to restore the intracellular Ca2+ homeostasis through the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) channel. SERCA2 degradation caused by Cd2+ can be inhibited by the proteasome inhibitor MG132, indicating the involvement of the proteasomal protein degradation pathway in maintaining SERCA2 stability. Targeting SERCA2 and the associated proteasome may provide a new therapeutic approach for preventing Cd2+-induced cytotoxicity and renal injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cell Biology
Baiying Li, Liwen Jiang
Summary: The regulation of autophagy in plants is still poorly understood, but recent research has identified the role of ufmylation components in maintaining ER homeostasis under salt stress. The expression of Ufm1-conjugating enzyme and Ufm1 protein increases in response to salt stress, indicating their involvement in regulating reticulophagy in plants.
Article
Cell Biology
Youkun Bi, Yan Chang, Qun Liu, Yang Mao, Kui Zhai, Yuanli Zhou, Renjie Jiao, Guangju Ji
Summary: This study reveals a novel function of CG9911 in promoting fat storage by regulating ER Ca2+ signal in Drosophila. Mutant flies with deleted CG9911 show decreased lipid storage, increased lipolysis, and altered expression of lipolysis related genes, indicating the importance of CG9911 in lipid metabolism and energy homeostasis. Additionally, the phenotype is enhanced under ER stresses and suppressed by a reduction in ER Ca2+, suggesting the intricate regulatory mechanisms involved in fat storage in Drosophila.
Article
Environmental Sciences
Nan Li, Bao-Jin Yi, Muhammad Asmat Ullah Saleem, Xue-Nan Li, Jin Long Li
Summary: This study investigates the role of autophagy in cadmium-induced cytotoxicity in bird hepatocytes. Low-dose cadmium activates autophagy, reducing oxidative stress and cell death, while high-dose cadmium inhibits autophagy and promotes apoptosis. The autophagy agonist Rapamycin reduces cadmium-induced oxidative stress and cytotoxicity, while the autophagy inhibitor 3-Methyladenine has the opposite effect.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Jun Chen, Li Li, Xueyang Bai, Lili Xiao, Jiahong Shangguan, Wenjing Zhang, Xiangqin Zhang, Shen Wang, Gangqiong Liu
Summary: Panax notoginseng saponins (PNS) protects against thapsigargin-induced ER stress and associated apoptosis in cardiac myocytes by regulating mitochondrial injury and ROS overproduction through modulation of autophagy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Alfred Yamoah, Priyanka Tripathi, Haihong Guo, Leonie Scheve, Peter Walter, Sandra Johnen, Frank Mueller, Joachim Weis, Anand Goswami
Summary: The rd10 mouse model of retinitis pigmentosa (RP) is valuable for studying the pathogenic mechanisms of RP. Our study shows that early disturbances of proteostasis and autophagy, as well as abnormal cytoplasmic RBP aggregation, are associated with progressive neurodegeneration in the rd10 mouse retina.
Article
Biochemistry & Molecular Biology
Silvia Sposito, Agnese Secondo, Antonio Massimiliano Romanelli, Antonio Montefusco, Merlin Nanayakkara, Salvatore Auricchio, Maria Vittoria Barone, Ivana Caputo, Gaetana Paolella
Summary: In this study, the response of skin-derived fibroblasts from CD and control subjects to the ER stress inducer thapsigargin was investigated, revealing molecular features of the CD cellular phenotype. It was found that CD cells had lower cytosolic and ER Ca2+ levels compared to control cells, and showed slightly different responses in terms of ER stress activation and autophagic marker expression. Overall, this study identified further molecular features of CD cells and highlighted their reduced ability to adapt to stress conditions and respond in a physiological manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Corina T. Madreiter-Sokolowski, Benjamin Gottschalk, Armin A. Sokolowski, Roland Malli, Wolfgang F. Graier
Summary: Cancer cells have increased energy demands and maintaining mitochondrial Ca2+ homeostasis is crucial for their survival. The ER-mitochondrial linkage and UCP2 play key roles in the mitochondrial Ca2+ uptake route in cancer cells. Disrupting the balance of these factors can lead to cancer cell death.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Haotian Xue, Huabin Cao, Chenghong Xing, Jiapei Feng, Linwei Zhang, Caiying Zhang, Guoliang Hu, Fan Yang
Summary: The study demonstrated that selenium has a protective effect against cadmium-induced oxidative stress and autophagy in the brain. Selenium treatment can inhibit cadmium-induced degenerative changes in cells and restore the balance of the redox system. Furthermore, selenium can also suppress cadmium-induced autophagy and activation of the Nrf2 signaling pathway.
Article
Pharmacology & Pharmacy
Hao Zhao, Yue Xu, Xinlei Song, Qingchen Zhang, Yajie Wang, Haiyan Yin, Xiaohui Bai, Jianfeng Li
Summary: The study aimed to investigate the mechanism(s) of cisplatin on auditory cells in vitro, focusing on the changes in calcium homeostasis and related channels. Cisplatin induced apoptosis in auditory cells through ER stress and mitochondrial pathway, accompanied by alterations in calcium homeostasis. Interestingly, IP3R dissociation from beclin-1 may play a role in autophagy activation under cisplatin insult.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Environmental Sciences
Jiapei Feng, Fan Yang, Huansheng Wu, Chenghong Xing, Haotian Xue, Linwei Zhang, Caiying Zhang, Guoliang Hu, Huabin Cao
Summary: Cadmium has a significant impact on agricultural production, but selenium can alleviate its toxicity. This study aimed to investigate the effects of selenium on cadmium-induced heart injury and found that selenium may protect the heart from cadmium-induced pyroptosis, autophagy, and apoptosis by interfering with the PI3K/AKT/PTEN signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ashish Tyagi, Balaji Chandrasekaran, Ajit K. Navin, Vaibhav Shukla, Becaa V. Baby, Murali K. Ankem, Chendil Damodaran
Summary: Chronic exposure to Cd leads to malignant transformation of prostate epithelial cells by generating persistent ROS and ER stress. Acute or chronic Cd exposure activates NOX1 assembly, which in turn activates UPR via phosphorylation of PERK, eIF2 alpha, and selective translation of ATF4 to generate ROS and ER stress. Chronic Cd exposure leads to defective autophagy, while acute Cd exposure does not. This study demonstrates that assembly of NOX1 complex proteins is indispensable for Cd-induced persistent ROS and controls ER stress-induced defective autophagy in mice and humans.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Food Science & Technology
Yujie Zhong, Chengni Jin, Jiahui Han, Jiachang Zhu, Qi Liu, Dianjun Sun, Xiaodong Xia, Yu Zhang, Xiaoli Peng
Summary: The study shows that DIO exerts protective effects against kidney injury, mitochondrial dysfunction, and cell apoptosis by inhibiting ER stress and maintaining Ca2+ homeostasis and Bcl2 expression.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Environmental Sciences
Caiying Zhang, Tianjin Lin, Gaohui Nie, Ruiming Hu, Shaoxing Pi, Zejing Wei, Chang Wang, Guyue Li, Guoliang Hu
Summary: The study showed that excessive molybdenum and cadmium exposure in duck kidneys caused histological abnormalities and disruptions in calcium homeostasis and autophagy processes, potentially leading to nephrotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Environmental Sciences
Attila Csaba Kondor, Anna Viktoria Vancsik, Laszlo Bauer, Lili Szabo, Zoltan Szalai, Gergely Jakab, Gabor Maasz, Marta Pedrosa, Maria Jose Sampaio, Ana Rita Lado Ribeiro
Summary: This review provides a critical overview of research on the removal efficiency of priority substances and compounds of emerging concern through bank filtration, discussing influencing factors and future challenges. The findings show that the efficiency of bank filtration is influenced by multiple factors and varies for different substances.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Xinyan Wang, Shuai Zhang, Huihui Yan, Zhao Ma, Yunshan Zhang, Haining Luo, Xueli Yang
Summary: This study investigated the association between ambient PM2.5, O3 pollution, and ovarian reserve in reproductive-aged Chinese women. The results showed that increased exposure to PM2.5 and O3 was associated with decreased AMH levels, indicating reduced ovarian reserve. Notably, the effects of O3 exposure on ovarian reserve were different from those of PM2.5 exposure.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Tingting Ma, Yanjuan Ding, Fengjiao Xu, Chen Zhang, Min Zhou, Ya Tang, Yanrong Chen, Yating Wen, Rufei Chen, Bin Tang, Shigui Wang
Summary: The dragonfly species Orthetrum albistylum can accumulate heavy metals, and its heat shock protein genes have the potential to serve as biomarkers for monitoring environmental pollutants.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Naoto Ishiwaka, Koya Hashimoto, Masayoshi K. Hiraiwa, Francisco Sanchez-Bayo, Taku Kadoya, Daisuke Hayasaka
Summary: Systemic insecticides and rising temperatures have combined effects on the abundance of Odonata nymphs in paddy fields. The standalone effect of insecticide exposure decreased the Odonata community, while nymphs decreased synergistically with temperature rise in paddy water. However, the impacts of each stressor alone varied among species.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Marco Vecchiato, Carlo Barbante, Elena Barbaro, Francois Burgay, Warren R. L. Cairns, Alice Callegaro, David Cappelletti, Federico Dallo, Marianna D'Amico, Matteo Feltracco, Jean-Charles Gallet, Andrea Gambaro, Catherine Larose, Niccolo Maffezzoli, Mauro Mazzola, Ivan Sartorato, Federico Scoto, Clara Turetta, Massimiliano Varde, Zhiyong Xie, Andrea Spolaor
Summary: The Arctic region is facing contamination from long-range pollution and local human activities. Polycyclic Aromatic Hydrocarbons (PAHs) are used as environmental indicators for emission, transport, and deposition processes. Research conducted in the Arctic surface snow in Ny-Ålesund, Svalbard from October 2018 to May 2019 shows that long-range inputs of PAHs mainly occur in winter, while the most abundant analyte retene exhibits opposite seasonal trends.
ENVIRONMENTAL POLLUTION
(2024)
Review
Environmental Sciences
Maoshui Zhuo, Zhijie Chen, Xiaoqing Liu, Wei Wei, Yansong Shen, Bing-Jie Ni
Summary: This paper discusses the application of three catalytic processes (photocatalysis, electrocatalysis, and biocatalysis) in the management of microplastic pollution, and introduces the efficiency and catalytic mechanisms of different catalysts. It also proposes the development prospects for sustainable management of microplastic pollution.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Shiyu Chen, Zhenzhen Shi, Qiang Zhang
Summary: In this study, a human physiologically based pharmacokinetic (PBPK) model of diethyl phthalate (DEP) was developed to assess its toxicity. The model considers the distribution and metabolism of DEP and its active metabolite monoethyl phthalate (MEP) in different tissue compartments. Sensitivity analysis and Bayesian Markov chain Monte Carlo (MCMC) simulations were performed to evaluate the uncertainty and variability of the model parameters. The results suggest that dermal absorption is an important route of exposure to DEP in the environment.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Bangguo Wang, Lijing Wang, Wenxi Cen, Tao Lyu, Peter Jarvis, Yang Zhang, Yuanxun Zhang, Yinghui Han, Lei Wang, Gang Pan, Kaili Zhang, Wei Fan
Summary: This study investigates the feasibility and mechanisms of a chemical-free nanobubble-based AOP for treating organic micropollutants in water. The results show that the oxygen nanobubble AOP has a significantly higher removal efficiency compared to air and nitrogen nanobubbles. The treatment performance is not affected by pH and the presence of ions. Higher initial concentrations of the micropollutant lead to slower treatment processes, but similar removal performance is achieved in the end. The presence of organic matter reduces the removal rate of the micropollutant. The results have practical feasibility for water and wastewater treatment.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Yingmei Huang, Jicai Yi, Yao Huang, Songxiong Zhong, Bin Zhao, Jing Zhou, Yuxuan Wang, Yiwen Zhu, Yanhong Du, Fangbai Li
Summary: This study investigates the impact of biochar on methylmercury (MeHg) accumulation in rice. The results show that biochar reduces MeHg levels in paddy soils by decreasing bioavailable Hg and microbial Hg methylation. Additionally, biochar decreases the uptake and translocation of MeHg in rice plants, resulting in a reduction of MeHg accumulation in rice grains.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Nengde Zeng, Fei Huang, Jiani Du, Chenghao Huang, Qian Yang, Xinhua Zhan, Baoshan Xing
Summary: This study investigates the protein targets and protein-ligand interactions related to PAH contamination in crop xylem sap using computational tools. The results show that phenanthrene has a more pronounced effect on the xylem sap proteins of maize and wheat, with maize DEPs associated with lipid biosynthesis and wheat DEPs exhibiting an increase in ABC transporters. This study provides insights into the regulation and movement of PAHs within plant xylem.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Xinwei Chen, Hao Ma, Run Wang, Man Wang, Binbin Zhu, Yanqing Cong, Xiayue Zhu, Guoqin Wang, Yi Zhang
Summary: Co3O4/TiO2-NRs electrodes with excellent photoresponse were prepared via plasma-assisted modification of Co3O4 on TiO2. The combination of Co3O4 and TiO2 improved the light utilization efficiency and showed potential for degradation of pollutants.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Wenjing Ji, Liying Song, Jing Wang, Hongqing Song
Summary: This study conducted a life-cycle assessment to examine the correlation between natural gas consumption and carbon emissions in different end uses in China. The results showed that both natural gas consumption and life-cycle carbon emissions have been increasing since 2017. Significant variations in NG life-cycle carbon emissions were found across different provinces and sectors, highlighting the need for targeted efforts to reduce carbon emissions.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Youyi Chen, Boxuan Zhang, Pojun Zhang, Guogui Shi, Hao Liang, Wu Cai, Jingyu Gao, Sumin Zhuang, Kaiyin Luo, Jiaqi Zhu, Chaoxiang Chen, Kunyu Ma, Jinrong Chen, Chun Hu, Xueci Xing
Summary: The synergistic effects of trace sulfadiazine and cast-iron corrosion scales on the formation of disinfection by-products in drinking water distribution systems were investigated. The presence of magnetite resulted in increased concentrations of DBPs due to the higher microbial activity and enhanced microbial extracellular electron transport pathway. The study highlights the importance of considering trace antibiotics pollution and corrosion scales in water sources for DBP control.
ENVIRONMENTAL POLLUTION
(2024)
Review
Environmental Sciences
Bishwa Raj Pokharel, Vijay Sheri, Manoj Kumar, Zhiyong Zhang, Baohong Zhang
Summary: This review summarizes the interactions, uptake, and transport of aluminum nanoparticles (Al-NPs) in plants, highlighting their negative effects on plant growth and development, as well as their potential to alter plant defense systems and gene expression.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Yonglu Wang, Fengsong Zhang, Xiaoyong Liao, Xiao Yang, Guixiang Zhang, Liyun Zhang, Chaojun Wei, Pengge Shi, Jiongxin Wen, Xiaorong Ju, Can Xu, Yang Liu, Ying Lan
Summary: This study aims to explore the effects of thiencarbazone-methyl center dot isoxaflutole on soil microflora and the potential mitigation mechanisms to bacterial communities. It was found that increasing the application of thiencarbazone-methyl center dot isoxaflutole resulted in increased stress on soil bacterial community structure and diversity. Increasing soil pH was recognized as a key factor in improving the diversity and structure of soil microflora. Supplemental use of nitrapyrin or modified attapulgite can increase soil pH and improve bacterial diversity.
ENVIRONMENTAL POLLUTION
(2024)