Probabilistic human health risk assessment of perfluorooctane sulfonate (PFOS) by integrating in vitro, in vivo toxicity, and human epidemiological studies using a Bayesian-based dose-response assessment coupled with physiologically based pharmacokinetic (PBPK) modeling approach

Title

Probabilistic human health risk assessment of perfluorooctane sulfonate (PFOS) by integrating in vitro, in vivo toxicity, and human epidemiological studies using a Bayesian-based dose-response assessment coupled with physiologically based pharmacokinetic (PBPK) modeling approach

Authors

Keywords

Dose-response analysis, Interspecies extrapolation, Perfluoroalkyl substances (PFAS), Perfluorooctane sulfonate (PFOS), Physiologically based pharmacokinetic (PBPK) modeling, Risk assessment

Journal

ENVIRONMENT INTERNATIONAL

Volume 137, Issue -, Pages 105581

Publisher

Elsevier BV

Online

2020-02-20

DOI

10.1016/j.envint.2020.105581