Article
Surgery
Weiwei Ying, Yanping Hu, Haibin Zhu
Summary: This study found that CD44, MMP-2, and MMP-9 may play critical roles in the pathogenesis of pelvic organ prolapse (POP) and may be candidate biomarkers of POP progression.
FRONTIERS IN SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Kanagaraj Gomathi, Muthukumar Rohini, Nicola C. Partridge, Nagarajan Selvamurugan
Summary: This study demonstrated the transcriptional regulation of MMP13 by TGF-beta 1 via Runx2 acetylation in rat osteoblastic cells, contributing to the knowledge of events presiding bone metabolism.
BIOLOGICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Dermatology
I Cosgarea, A. T. McConnell, T. Ewen, D. Tang, D. S. Hill, M. Anagnostou, M. Elias, R. A. Ellis, A. Murray, L. C. Spender, P. Giglio, M. Gagliardi, A. Greenwood, M. Piacentini, G. J. Inman, G. M. Fimia, M. Corazzari, J. L. Armstrong, P. E. Lovat
Summary: The loss of AMBRA1 in the peritumoral epidermis is associated with an increased risk of metastasis in early-stage melanoma patients, possibly due to disruption of epidermal integrity. TGF-beta 2 signaling may play a role in this process by downregulating AMBRA1 and other epidermal markers, leading to decreased epidermal integrity and tumor ulceration.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Chen
Summary: This study found that TGF-beta RI and TGF-beta RII mediate matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes, leading to decreased cell viability.
Article
Medicine, Research & Experimental
Hanan M. Hassan, Sherif M. H. El-Kannishy, Abdullah Alattar, Reem Alshaman, Ahmed M. Hamdan, Mohammed M. H. Al-Gayyar
Summary: iCRT14 treatment showed significant antitumor effects against hepatocellular carcinoma (HCC) in rats by increasing survival rate, reducing alpha-fetoprotein levels, and decreasing the average number of nodules. It also attenuated hepatic tissue damage and inflammation by suppressing the expression of specific proteins.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Young Shin Lee, Hojung Choi, Hae-Ryung Cho, Woo-Chang Son, You-Soo Park, Chi-Dug Kang, Jaeho Bae
Summary: In this study, it was found that TGF-beta reduced the surface protein levels of five NKG2DLs in lung cancer cells without altering transcription levels. Galunisertib reversed this effect of TGF-beta on NKG2DLs expression.
Review
Medicine, Research & Experimental
Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang
Summary: Targeting TGF beta signaling for cancer therapy presents challenges and opportunities, as inhibitors can enhance chemotherapy efficacy but must also consider the dual role of TGF beta in normal tissues and tumors to avoid unwanted side effects.
Article
Pathology
Mei Sun, Elena Koudouna, Devon Cogswell, Marcel Y. Avila, Manuel Koch, Edgar M. Espana
Summary: Collagen XII plays a crucial role in regulating the activity and latency of TGF-beta in the corneal stroma. Its absence leads to hypertrophic corneal tissue with abnormal up-regulation of TGF-beta activation and decreased latent storage. Collagen XII regulates the synthesis and deposition of collagens in the extracellular matrix, and it controls the balance between active and latent TGF-beta.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Hematology
Ryosuke Taniguchi, Yuichi Ohashi, Jung Seok Lee, Haidi Hu, Luis Gonzalez, Weichang Zhang, John Langford, Yutaka Matsubara, Bogdan Yatsula, George Tellides, Tarek M. Fahmy, Katsuyuki Hoshina, Alan Dardik
Summary: Endothelial cell-targeted TGF-beta inhibition may be a translational strategy to improve AVF patency.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.
Article
Immunology
Rittika Chunder, Verena Schropp, Samir Jabari, Manuel Marzin, Sandra Amor, Stefanie Kuerten
Summary: There is a growing interest in studying the presence and role of B cell aggregates in the central nervous system of multiple sclerosis patients. Research shows that matrix metalloproteinase-3, associated with B cell aggregates, plays a modulatory role in B cell activation and cytokine production. Gene array data confirms that matrix metalloproteinase-3 affects the proliferation and survival profiles of B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Savalan Babapoor-Farrokhran, Roozbeh Tarighati Rasekhi, Deanna Gill, Jafar Alzubi, Sumeet K. Mainigi
Summary: Atrial fibrillation is a common clinically significant arrhythmia with four fundamental pathophysiological mechanisms, with TGF-beta playing a key role. Studies have shown that TGF-beta 1 is involved in the development and propagation of atrial fibrillation.
Article
Chemistry, Analytical
Mohammad Bagher Miranzadeh, Gholamreza Mostafaii, Raheleh Kafaei, Mohammad Rezvani Ghalhari, Fatemeh Atoof, Gholamreza Hoseindoost, Fahimeh Karamali
Summary: This study aimed to determine the concentrations of heavy metals in cream foundations. The results showed that the total content of heavy metals was higher in the two Iranian brands than the two imported ones. According to the guidelines, all the tested samples were within the safe range, but the high concentrations of trace elements in the samples should not be overlooked for their potential health consequences on consumers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
GholamReza Mostafaii, Zahra Bakhtyari, Fatemeh Atoof, Mansour Baziar, Reza Fouladi-Fard, Mostafa Rezaali, Nezam Mirzaei
Summary: This study assessed the concentration and health risks of heavy metals in atmospheric dustfall in Dezful City, Iran. Industrial activities and traffic were identified as the main sources of heavy metal contamination, but no significant carcinogenic risks were found.
JOURNAL OF ENVIRONMENTAL HEALTH SCIENCE AND ENGINEERING
(2021)
Article
Virology
Yaser Fathi, Elaheh Ghasemzadeh Hoseini, Fatemeh Atoof, Reza Mottaghi
Summary: Dry mouth was found to be a symptom that could occur before common symptoms in COVID-19 patients. With treatment, dry mouth gradually disappeared. Therefore, it could potentially be used for early diagnosis, quarantine, and treatment.
Article
Microbiology
Fereshteh Badie, Mahmood Saffari, Rezvan Moniri, Behrang Alani, Fatemeh Atoof, Ahmad Khorshidi, Mohammad Shayestehpour
Summary: The study evaluated the combined effects of temperature and pH on the expression of biofilm, stress, and virulence genes in Salmonella Enteritidis and Salmonella Typhimurium. The findings indicated that temperature and pH did not have a significant effect on the gene expression levels in these Salmonella strains.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gholamreza Mostafaii, Fahimeh Karamali, Zahra AbooSaedi, Fatemeh Atoof, Mohsen Hesami Arani, Mohammad Bagher Miranzadeh
Summary: This study in Kashan, Iran assessed the dermal risk of heavy metals in hair dyes, finding concentrations below permissible limits with no apparent carcinogenic or non-carcinogenic risks. However, some heavy metals exceeded allergenic limits, indicating potential health risks for users.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Environmental Sciences
Mahdiyeh Mohammadzadeh, Nezam Mirzaei, Gholamreza Mostafaii, Fatemeh Atoof, Mohammad Bagher Miranzadeh, Rouhullah Dehghani
Summary: This study examined the concentrations of heavy metals in popular depilatory products in the Iranian markets and found that most products had concentrations below the maximum allowable limits as defined by the Institute of Standards and Industrial Research of Iran (ISIRI). The study also concluded that the carcinogenic and non-carcinogenic risks associated with using these products were low for consumers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medical Informatics
Zahra Meidani, Fatemeh Atoof, Zohre Mobarak, Ehsan Nabovati, Reza Daneshvar Kakhki, Ebrahim Kouchaki, Esmaeil Fakharian, Ali Mohammad Nickfarjam, Felix Holl
Summary: This study aims to develop and implement a mobile app for head CT scan appropriateness criteria and investigate its effect on CT scan order. The results show that although there was an increase in CT scan utilization during the intervention phase, there were no significant differences after the intervention ceased. Therefore, further research is needed to determine the impact of mobile devices on physicians' CT scan ordering behavior.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2022)
Article
Pharmacology & Pharmacy
Tamara Talakesh, Nasibeh Tabatabaee, Fatemeh Atoof, Akbar Aliasgharzadeh, Mostafa Sarvizade, Bagher Farhood, Masoud Najafi
Summary: This study aimed to evaluate the efficacy of nano-curcumin in alleviating radiation-induced skin reactions (RISRs) in breast cancer patients. The results showed that the administration of nano-curcumin could alleviate radiation-induced skin toxicity, although the effect was not significant.
CURRENT RADIOPHARMACEUTICALS
(2022)
Article
Nursing
Mahdi Moheb, Mahboubeh Rezaei, Ismail Azizi-Fini, Fatemeh Atoof, Mohammad Ali Saadati
Summary: This study compared the effects of forced-air warming and warmed intravenous fluid on the comfort and prevention of shivering in patients undergoing orthopaedic surgery with spinal anesthesia. The results showed that forced-air warming was more effective in providing comfort and preventing shivering than warmed intravenous fluid.
JOURNAL OF PERIANESTHESIA NURSING
(2022)
Article
Orthopedics
Esmaeil Fakharian, Masoumeh Abedzadeh-Kalahroudi, Fatemeh Atoof, Voorya Nooranipour, Javid Azadbakht
Summary: This study found that the administration of tranexamic acid (TXA) did not prevent enlargement of post-traumatic intracranial hemorrhage (IPH) or improve neurological outcomes in patients with traumatic brain injuries (TBI).
ARCHIVES OF TRAUMA RESEARCH
(2022)
Article
Orthopedics
Mahtab Hadavand, Zahra Zanjani, Abdollah Omidi, Fatemeh Atoof, Esmaeil Fakharian
Summary: This study aimed to investigate the effect of group acceptance and commitment therapy (ACT) on the family function, experiential avoidance, and anxiety of traumatic brain injury (TBI) patients' caregivers. The results showed that the ACT program significantly decreased caregivers' anxiety, experiential avoidance, and most dimensions of family functions.
ARCHIVES OF TRAUMA RESEARCH
(2022)
Article
Medicine, Research & Experimental
Mohammad Esmaeilnia, Mahmood Saffari, Somaye Rashki, Zeynab Marzhoseyni, Azad Khaledi, Gholam Abbas Moosavi, Fatemeh Atoof, Behrang Alani
Summary: This study investigated the molecular typing of extended-spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae isolates from Beheshti Hospital in Iran. The results showed that there was a common molecular signature among both clinical and environmental K. pneumoniae isolates, indicating a similar genotype and likely a common origin. Therefore, it is important for hospitals to implement effective infection control systems to reduce the spread of ESBL strains.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Reza Nikbakht, Marzieh Arokh, Babak Ebrahimi, Mohammad Miranzadeh, Davarkhah Rabbani, Fatemeh Atoof
Summary: The study found that the groundwater level in Kashan plain has been decreasing over the past 28 years, with an average annual drop of 0.54 meters, mainly due to uncontrolled harvesting. Management strategies need to be implemented to ensure sustainable use of water resources in the area.
INTERNATIONAL ARCHIVES OF HEALTH SCIENCES
(2021)
Article
Substance Abuse
Mohammad Ghalhari, Ahmad Mehri, Rouhullah Dehghani, Ashraf Tehrani, Fatemeh Atoof
Summary: The study investigated the prevalence of alcohol use and associated factors among Iranian students of medical sciences, finding that 4% of students consume alcohol, with a higher proportion among males. Alcohol use was associated with family, close friends, tendencies to use alcohol in the last year, and living in a dormitory.
ALKOHOLIZM I NARKOMANIA-ALCOHOLISM AND DRUG ADDICTION
(2021)
Article
Education, Scientific Disciplines
Mohammad Setareh, Negin Masoudi Alavi, Fatemeh Atoof
Summary: The severity of illness in ICU patients was found to be significantly related to length of stay, patient outcomes at discharge, and one month later. An initial SOFA score of 12 or higher may be suggested as a cutoff point for poor prognosis in ICU patients.
JOURNAL OF EDUCATION AND HEALTH PROMOTION
(2021)
