Review
Oncology
Conor E. Steuer, Glenn J. Hanna, Kartik Viswanathan, James E. Bates, Azeem S. Kaka, Nicole C. Schmitt, Alan L. Ho, Nabil F. Saba
Summary: Salivary gland cancers are rare and histologically diverse tumors that can range from indolent to aggressive, causing significant morbidity and mortality. Surgical resection is the main treatment, but radiation and systemic therapy are also critical. Due to their rarity and heterogeneity, a multidisciplinary approach is best for managing these cancers. This review highlights current standards of care and exciting new research aiming to improve patient outcomes for salivary gland cancers.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Oncology
Guoqiang Xu, Qiaoli Wang, Xingrao Wu, Chunyan Lv, Guilin Zeng, Zhihong Xue, Ruixue Cao, Nan Zhang, Wei Xiong, Qin Huang
Summary: The study found that induction chemotherapy plus concurrent chemoradiotherapy improved survival outcomes in patients with locally advanced nasopharyngeal carcinoma compared to concurrent chemoradiotherapy alone, but also increased the risk of certain adverse reactions. Subgroup analysis suggested different outcomes depending on the cisplatin regimen used, warranting further investigation.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Carl Frederik Haugaard, Simon Andreasen, Patrick R. G. Eriksen, Caroline Olsen, Katalin Kiss, Kristine Bjorndal, Marie Westergaard-Nielsen, Preben Homoe
Summary: This retrospective cohort study examined the histological tumor types, location, incidence, and survival of benign and malignant salivary gland tumors in the Greenlandic Inuit population. The study found that 76% of the tumors were benign, with pleomorphic adenoma being the most common type. Malignant tumors accounted for 24% of the cases, with lymphoepithelial carcinoma being the most common type. The study provides valuable insights into the epidemiology of salivary gland tumors in the Greenlandic Inuit population.
Article
Medicine, General & Internal
Xinmao Song, Shengzi Wang, Ji Li, Li Yan, Fu Chen, Jie Wang
Summary: The study found that the combination of nimotuzumab with chemoradiotherapy is effective for the treatment of nasopharyngeal carcinoma, especially when used in combination with induction chemotherapy and concurrent chemoradiotherapy. The addition of nimotuzumab did not result in a significant increase in toxicities.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Oncology
Xiaoshuang Niu, Peiyao Liu, Xin Zhou, Xiaoshen Wang, Chaosu Hu
Summary: This study evaluated the role of postoperative radiotherapy (PORT) in patients with lymphoepithelial carcinoma of salivary gland (LECSG) and provided individualized treatment recommendations. The results showed that PORT had a positive prognostic effect on progression-free survival (PFS) and locoregional control (LRC) of patients. It was found to be especially beneficial for patients with a primary tumor diameter larger than 3 cm and/or more than 2 positive lymph nodes.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Zhi-Cheng Liu, Ke-Hao Zeng, Zhen-Bang Gu, Run-Pu Chen, Yi-Jing Luo, Lin-Quan Tang, Kai -Bin Zhu, Yan Liu, Xue-Song Sun, Lei Zeng
Summary: This study investigated the efficacy of induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) versus CCRT alone in patients with N3 nasopharyngeal carcinoma (NPC). The results showed that IC + CCRT achieved better survival outcomes compared with CCRT alone, indicating the positive impact of chemotherapy on the treatment of N3 NPC patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Qiulu Zhong, Danjing Luo, Xiangde Li, Qinghua Du, Qianfu Liang, Wenqi Liu, Jian Li, Xiaodong Zhu
Summary: This study aimed to evaluate the efficacy of adding induction chemotherapy or adjuvant chemotherapy to concurrent chemoradiotherapy in patients with T3-4N0-1M0 nasopharyngeal carcinoma. The study found that adding induction chemotherapy or adjuvant chemotherapy did not significantly improve the prognosis of these patients.
CANCER BIOLOGY & THERAPY
(2023)
Article
Cell Biology
Xiaoli Mu, Hongyan Liu, Juan Wu, Shi Chen, Xingchen Peng, Jingjing Wang, Zhigong Wei, Ling He, Jiyan Liu, Zejun Lu, Yonglin Su
Summary: In patients with locoregionally advanced nasopharyngeal carcinoma, induction chemotherapy plus concurrent chemoradiotherapy achieved comparable survival outcomes to concurrent chemoradiotherapy plus adjuvant chemotherapy with a lower incidence of toxicity.
Review
Biochemistry & Molecular Biology
Malin Tordis Meyer, Christoph Watermann, Thomas Dreyer, Sueleyman Erguen, Srikanth Karnati
Summary: Salivary gland tumors consist of both malignant and benign tumors, with the most common malignant tumors being mucoepidermoid carcinoma, adenoid cystic carcinoma, and acinic cell carcinoma, and the most common benign tumor being pleomorphic adenoma. Due to their low incidence rates and complex histological patterns, diagnosing salivary gland tumors accurately can be challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Martha S. van Ginkel, Tineke van der Sluis, Marian L. C. Bulthuis, Henk J. Buikema, Erlin A. Haacke, Suzanne Arends, Stine Harder, Fred K. L. Spijkervet, Hendrika Bootsma, Arjan Vissink, Frans G. M. Kroese, Bert van der Vegt
Summary: Objective digital image analysis (DIA) algorithm can be used to identify lymphoepithelial lesions (LELs) in salivary glands of primary Sjögren's syndrome (pSS) patients. The presence of intraepithelial B-lymphocytes can serve as a clear indicator of pSS and an objective alternative to LEL scoring.
Review
Oncology
Jianing Wang, Linlin Xiao, Shuai Wang, Qingsong Pang, Jun Wang
Summary: Additional induction chemotherapy or consolidation chemotherapy compared to concurrent chemoradiotherapy alone provides short-term survival benefits for unresectable esophageal cancer patients, and CCRT followed by CCT significantly reduces the risk of distant metastases.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ting-Chieh Huang, Chi-Jen Chen, Yi-Fang Ding, Yi-No Kang
Summary: IC-CCRT may be beneficial for patients with nasopharyngeal carcinoma in the medium term, although no significant difference was observed in 5-year survival compared with CCRT. All outcomes had decreased survival rate from the 3-year to 5-year follow-up. Differences in patient ethnicities and regimens of IC-CCRT may be sources of heterogeneity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Min Tang, Zhongxiong Jia, Ju Zhang
Summary: Induction chemotherapy followed by cisplatin-based concurrent chemoradiotherapy significantly improves survival outcomes for patients with locally advanced nasopharyngeal carcinoma compared to cisplatin-based CCRT alone, but is also associated with a markedly increased risk of treatment-related adverse events.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Oncology
Yuzhen Xi, Xiuhong Ge, Haiming Ji, Luoyu Wang, Shaofeng Duan, Haonan Chen, Mengze Wang, Hongjie Hu, Feng Jiang, Zhongxiang Ding
Summary: This study established an MRI radiomics model and a Delta radiomics model to predict tumor retraction after induction chemotherapy combined with concurrent chemoradiotherapy for primary nasopharyngeal carcinoma in non-endemic areas and validated their efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shuiqing He, Danjie He, Jiaxin Li, Hongwei Yu, Shoumin Bai, Cheng Xu, Ying Huang
Summary: This study aimed to explore prognostic factors and the role of postoperative radiotherapy (PORT) in patients with lymphoepithelial carcinoma of the salivary glands (LECSG). The study found that the number of positive lymph nodes (PLNs) >= 3 and tumor size >= 3 cm were independent factors for PFS in patients with neck dissection (ND). Additionally, detectable EBV DNA after surgery was a negative prognostic factor.
RADIOTHERAPY AND ONCOLOGY
(2023)
