Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 22, Pages 4213-4229Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2290-2
Keywords
Asymmetric cell division; Stem cells; Cell fate determination; Cell polarity; Plant development
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Funding
- NIGMS NIH HHS [R01 GM109080] Funding Source: Medline
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Asymmetric cell division is a fundamental mechanism that generates cell diversity while maintaining self-renewing stem cell populations in multicellular organisms. Both intrinsic and extrinsic mechanisms underpin symmetry breaking and differential daughter cell fate determination in animals and plants. The emerging picture suggests that plants deal with the problem of symmetry breaking using unique cell polarity proteins, mobile transcription factors, and cell wall components to influence asymmetric divisions and cell fate. There is a clear role for altered auxin distribution and signaling in distinguishing two daughter cells and an emerging role for epigenetic modifications through chromatin remodelers and DNA methylation in plant cell differentiation. The importance of asymmetric cell division in determining final plant form provides the impetus for its study in the areas of both basic and applied science.
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