Journal
CELLULAR AND MOLECULAR BIOENGINEERING
Volume 9, Issue 2, Pages 252-257Publisher
SPRINGER
DOI: 10.1007/s12195-016-0431-1
Keywords
Nuclear envelope; LINC complex; Membrane; Geometry
Funding
- NSF [CMMI 1437330]
- NIH [R01 EB014869, R01 GM102486]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1437395] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1437330] Funding Source: National Science Foundation
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The nuclear envelope segregates the nucleoplasm from the cytoplasm and is a key feature of eukaryotic cells. Nuclear envelope architecture is comprised of two concentric membrane shells which fuse at multiple sites and yet maintain a uniform separation of 30-50 nm over the rest of the membrane. Studies have revealed the roles for numerous nuclear proteins in forming and maintaining the architecture of the nuclear envelope. However, there is a lack of consensus on the fundamental forces and physical mechanisms that establish the geometry. The objective of this review is to discuss recent findings in the context of membrane mechanics in an effort to define open questions and possible answers.
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