Outrunning the Red Queen: bystander activation as a means of outpacing innate immune subversion by intracellular pathogens

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

(2015) Angela C. Collins et al.   Cell Host & Microbe

Modulation of the host innate immune and inflammatory response by translocated bacterial proteins

(2015) Seblewongel Asrat et al.   CELLULAR MICROBIOLOGY

Formation of a pathogen vacuole according toLegionella pneumophila: how to kill one bird with many stones

(2015) Ivo Finsel et al.   CELLULAR MICROBIOLOGY

Intracellular detection of viral nucleic acids

(2015) Konstantin MJ Sparrer et al.   CURRENT OPINION IN MICROBIOLOGY

Bacterial Membrane Vesicles Mediate the Release ofMycobacterium tuberculosisLipoglycans and Lipoproteins from Infected Macrophages

(2015) Jaffre J. Athman et al.   JOURNAL OF IMMUNOLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

(2015) Bappaditya Dey et al.   NATURE MEDICINE

IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis

(2015) Alan M. Copenhaver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viruses transfer the antiviral second messenger cGAMP between cells

(2015) A. Bridgeman et al.   SCIENCE

Transmission of innate immune signaling by packaging of cGAMP in viral particles

(2015) Matteo Gentili et al.   SCIENCE

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection

(2015) Sonali Patil et al.   Science Signaling

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection

(2015) Sonali Patil et al.   Science Signaling

Shigella Manipulates Host Immune Responses by Delivering Effector Proteins with Specific Roles

(2015) Hiroshi Ashida et al.   Frontiers in Immunology

Cellular Sensing of Viral DNA and Viral Evasion Mechanisms

(2014) Megan H. Orzalli et al.   Annual Review of Microbiology

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation

(2014) Cynthia A. Leifer et al.   IMMUNOLOGY LETTERS

Use of Transgenic Parasites and Host Reporters To Dissect Events That Promote Interleukin-12 Production during Toxoplasmosis

(2014) David A. Christian et al.   INFECTION AND IMMUNITY

TLR2 Regulates Gap Junction Intercellular Communication in Airway Cells

(2014) F. J. Martin et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Extracellular Vesicles from Leishmania-Infected Macrophages Confer an Anti-infection Cytokine-Production Profile to Naïve Macrophages

(2014) André Cronemberger-Andrade et al.   PLoS Neglected Tropical Diseases

The Frustrated Host Response to Legionella pneumophila Is Bypassed by MyD88-Dependent Translation of Pro-inflammatory Cytokines

(2014) Seblewongel Asrat et al.   PLoS Pathogens

Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System

(2013) Pierre-Yves Mantel et al.   Cell Host & Microbe

Human Plasmacytoid Dendritic Cells Sense Lymphocytic Choriomeningitis Virus-Infected Cells In Vitro

(2013) S. F. Wieland et al.   JOURNAL OF VIROLOGY

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

(2013) Andrea Ablasser et al.   NATURE

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR

(2013) Stanimir S Ivanov et al.   NATURE IMMUNOLOGY

IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8+ T cell responses to influenza A virus

(2013) Iris K Pang et al.   NATURE IMMUNOLOGY

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

Inflammasome-mediated cell death in response to bacterial pathogens that access the host cell cytosol: lessons from legionella pneumophila

(2013) Cierra N. Casson et al.   Frontiers in Cellular and Infection Microbiology

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

(2012) Marlène Dreux et al.   Cell Host & Microbe

Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration

(2012) S. B. Walters et al.   JOURNAL OF IMMUNOLOGY

Exosomes Isolated from Mycobacteria-Infected Mice or Cultured Macrophages Can Recruit and Activate Immune Cells In Vitro and In Vivo

(2012) P. P. Singh et al.   JOURNAL OF IMMUNOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Subversion of Cell Signaling by Pathogens

(2012) N. M. Alto et al.   Cold Spring Harbor Perspectives in Biology

Toxoplasma Co-opts Host Cells It Does Not Invade

(2012) Anita A. Koshy et al.   PLoS Pathogens

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

(2011) Mary F. Fontana et al.   PLoS Pathogens

Salmonella and Caspase-1: A complex Interplay of Detection and Evasion

(2011) Edward A. Miao et al.   Frontiers in Microbiology

Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection

(2010) Christoph Alexander Kasper et al.   IMMUNITY

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection

(2010) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Potentiation of Epithelial Innate Host Responses by Intercellular Communication

(2010) Tamas Dolowschiak et al.   PLoS Pathogens

Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

(2010) Kevin N. Couper et al.   PLoS Pathogens

Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System

(2009) Russell E. Vance et al.   Cell Host & Microbe

Targeting eEF1A by aLegionella pneumophilaeffector leads to inhibition of protein synthesis and induction of host stress response

(2009) Xihui Shen et al.   CELLULAR MICROBIOLOGY

In Situ IL-12/23p40 Production during Mycobacterial Infection Is Sustained by CD11bhigh Dendritic Cells Localized in Tissue Sites Distinct from Those Harboring Bacilli

(2009) A. G. Rothfuchs et al.   JOURNAL OF IMMUNOLOGY

Antiviral immunity in Drosophila requires systemic RNA interference spread

(2009) Maria-Carla Saleh et al.   NATURE

Targeting of immune signalling networks by bacterial pathogens

(2009) Igor E. Brodsky et al.   NATURE CELL BIOLOGY

DNA-triggered innate immune responses are propagated by gap junction communication

(2009) S. J. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila

(2008) Sunny Shin et al.   PLoS Pathogens