Journal
DYES AND PIGMENTS
Volume 175, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2019.108105
Keywords
Iridium(III); Self-assemble; Hyaluronic acid; Mitochondria targeting; Photodynamic therapy
Funding
- National Natural Science Foundation of China [21501121, 21501029]
- Natural Science Foundation of Shanghai [19ZR1434700]
- National Key R&D Program of China [2018YFC0115700]
- Shanghai Rising-Star Program [17QA1403500]
- Science and Technology Development Projects of USST [201710FZ114, 2018KJFZ147, 2019KJFZ169]
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Photodynamic therapy (PDT) is one of effective cancer therapy methods. It is important to develop a PDT reagent with tumor-targeted ability, high phototoxicity and low dark toxicity. In this study, an iridium(III) complex (Irpy) can electrostatically self-assemble with hyaluronic acid (HA) to form nanostructured Irpy-HA, which exhibited stable spheroid structure and outstanding ability of singlet oxygen (O-1(2)) generation. The photophysical property of Irpy has been well studied, which qualified green light absorption ability and could emit red phosphorescence. The nanostructure and stability of self-assembled Irpy-HA have been well investigated, which can keep its nanostructure at least 30 days. More importantly, Irpy-HA can target to a CD44 receptor in cancer cell membrane for enhancing internalization and selective disintegration. Then, Irpy can accumulate in mitochondria and generate O-1(2) to realize PDT-induced cell apoptosis by green light irradiation. The Irpy-HA could be used as a nanophotosensitizer for effective photodynamic therapy.
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