Journal
DNA REPAIR
Volume 91-92, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2020.102871
Keywords
Alzheimer's disease; Parkinson's disease; Mitochondrial DNA disturbances; Neuroinflammation; Peptide and protein aggregation; Oxidative stress
Categories
Funding
- Ministry of Education, Youth and Sports of the Czech Republic under the National Sustainability Programme II (Project BIOCEV-FAR) [LQ1604]
- project BIOCEV'' [CZ.1.05/1.1.00/02.0109]
- Charles University in Prague [SVV260521, UNCE 204064, Q26/LF1, Q27/LF1]
- Ministry of Health of the Czech Republic [17-32727A, RVO-VFN64165/2012]
- Ministry of Education, Youth and Sports of the Czech Republic [EATRIS-CZ LM2018133]
- Ministry of Industry and Trade of the Czech Republic [FV20572]
- Technology Agency of the Czech Republic [TN01000013]
- Grant Agency of Czech Republic [GACR 18-09296S]
- Research, Development and Education Operational Programme [CZ.02.1.01/0.0/0.0/16_019/0000785]
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Neurodegenerative diseases (e.g. Alzheimer's and Parkinson's disease) are becoming increasingly problematic to healthcare systems. Therefore, their underlying mechanisms are trending topics of study in medicinal research. Numerous studies have evidenced a strong association between mitochondrial DNA disturbances (e.g. oxidative damage, mutations, and methylation shifts) and the initiation and progression of neurodegenerative diseases. Therefore, this review discusses the risk and development of neurodegenerative diseases in terms of disturbances in mitochondrial DNA and as a part of a complex ecosystem that includes other important mechanisms (e.g. neuroinflammation and the misfolding and aggregation of amyloid-beta peptides, alpha-synuclein, and tau proteins). In addition, the influence of individual mitochondrial DNA haplogroups on the risk and development of neurodegenerative diseases is also described and discussed.
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