Targeting HSP70 and GRP78 in canine osteosarcoma cells in combination with doxorubicin chemotherapy

HSP70 desensitizes osteosarcoma cells to baicalein and protects cells from undergoing apoptosis

(2014) Lianghua Ding et al.   APOPTOSIS

VER-155008, a small molecule inhibitor of HSP70 with potent anti-cancer activity on lung cancer cell lines

(2014) Wei Wen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial–mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells

(2014) R L Carpenter et al.   ONCOGENE

The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma

(2013) M. Chatterjee et al.   HAEMATOLOGICA

Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions

(2012) Hongqin Zhuang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice

(2012) Gustaaf G. de Ridder et al.   MELANOMA RESEARCH

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

Heat shock protein expression in canine osteosarcoma

(2011) Mariarita Romanucci et al.   CELL STRESS & CHAPERONES

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Phase I Evaluation of STA-1474, a Prodrug of the Novel HSP90 Inhibitor Ganetespib, in Dogs with Spontaneous Cancer

(2011) Cheryl A. London et al.   PLoS One

Inhibition of the JNK/Bim pathway by Hsp70 prevents Bax activation in UV-induced apoptosis

(2010) Hui Li et al.   FEBS LETTERS

Cell Surface Relocalization of the Endoplasmic Reticulum Chaperone and Unfolded Protein Response Regulator GRP78/BiP

(2010) Yi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modulation of Akt and ERK1/2 Pathways by Resveratrol in Chronic Myelogenous Leukemia (CML) Cells Results in the Downregulation of Hsp70

(2010) Soumyajit Banerjee Mustafi et al.   PLoS One

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

(2009) Andrew J. Massey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia

(2008) Wen-Jie Huang et al.   INTERNATIONAL JOURNAL OF CANCER

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis

(2008) Hae Kyung Lee et al.   NEURO-ONCOLOGY