Review
Dermatology
Thrasyvoulos Tzellos, Christos C. Zouboulis
Summary: Hidradenitis suppurativa is a chronic skin inflammatory disease associated with various comorbidities, including cardiovascular diseases and increased suicide risk. It is important for clinicians to be aware of these comorbidities and design appropriate treatment strategies.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Asli Bilgic, Bilge Fettahlioglu Karaman, Duriye Deniz Demirseren, Levent Cinar, Nida Kacar, Aylin Türel Ermertcan, Emel Bulbul Baskan, Munevver Guven, Serkan Yazici, Tugba Özkök Akbulut, Derya Ucmak, Arzu Ataseven, Selami Aykut Temiz, Burhan Engin, Aysun Sikar Akturk, Hayriye Saricaoglu, Müge Güler Ozden, Hilal Ozdemir, Kifayet Mammadli, Koray Durmaz, Fatmagül Gulbasaran, Fadime Kilinc, Hatice Kaya Ozden, Melis Gonulal, Didem Didar Balci, Bengu Cevirgen Cemil, Sezgi Sarikaya Solak, Leyla Baykal Selcuk, Göknur Ozaydin Yavuz, Ibrahim Halil Yavuz, Levent Donmez, Erkan Alpsoy
Summary: This study investigated the internalized stigma state of HS patients and identified the factors affecting it. The study found that obesity, family history, low education and income level, vulva/scrotum involvement, and being actively treated are significant and independent predictive factors for high internalized stigma. HS patients internalize society's negative judgements, which may have a profound negative effect on access to health care. Therefore, addressing internalized stigma is crucial for improving healthcare quality, in addition to suppressing disease activity.
Letter
Dermatology
Rosalynn R. Z. Conic, Gabriella Fabbrocini, Claudio Marasca, Nicola L. Bragazzi, Watad Abdulla, Mohammad Adawi, Giovanni Damiani
Summary: This case-control study investigates the prevalence of ocular comorbidities in patients with hidradenitis suppurativa.
Review
Allergy
Kelsey R. van Straalen, Errol P. Prens, Johann E. Gudjonsson
Summary: Hidradenitis suppurativa is a chronic, inflammatory skin disorder that affects around 1% of the population and significantly impacts patients' quality of life. It is characterized by inflammatory lesions such as nodules, abscesses, and sinus tracts in areas like the armpits, groin, and buttocks, typically appearing during or after puberty. The development and maintenance of the disease involve a complex interplay of genetic predisposition, hormonal factors, obesity, and smoking. It is believed to stem from a defect in the hair follicle, leading to follicular plugging, cyst formation, and subsequent acute inflammation. Over time, acute lesions progress to a chronic condition with draining sinus tracts and extensive fibrosis. Hidradenitis suppurativa is associated with other immune-mediated inflammatory diseases, metabolic and cardiovascular disorders, and psychiatric comorbidities.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Dermatology
T. Nguyen, G. Damiani, L. A. Orenstein, I Hamzavi, G. B. Jemec
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs patients' quality of life. Patients with HS often experience significant diagnostic delays and the symptoms can lead to a decrease in quality of life.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Pediatrics
Colleen H. H. Cotton, Stella X. X. Chen, Sadaf H. H. Hussain, Irene Lara-Corrales, Andrea L. L. Zaenglein
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disorder mainly affecting areas with apocrine glands. It is common in Western populations, occurring in up to 2% of people, and its incidence is increasing in children and adults. Pediatric cases represent about one-third of all cases, with initial symptoms often appearing in childhood. Limited clinical studies and guidelines exist for pediatric hidradenitis suppurativa. This review covers the epidemiology, clinical presentation, comorbidities, and management of the disease in children. It also discusses the barriers to timely diagnosis and the significant physical and emotional impact on children and adolescents.
Review
Medicine, General & Internal
Ratnakar Shukla, Priyanka Karagaiah, Anant Patil, Katherine Farnbach, Alex G. Ortega-Loayza, Thrasivoulos Tzellos, Jacek C. Szepietowski, Mario Giulini, Hadrian Schepler, Stephan Grabbe, Mohamad Goldust
Summary: HS is a chronic inflammatory disease that typically begins in puberty and presents with painful nodules and sinus tracts. The disease may impact quality of life and management often requires a multidisciplinary approach. Medical treatment can be used in early stages while surgical intervention may be necessary in advanced stages.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Dermatology
Ellie Choi, Xue Ting Ooi, Nisha Suyien Chandran
Summary: Interest and research in hidradenitis suppurativa (HS) have grown in the past decade, expanding knowledge about associated comorbidities and treatment efficacy. Limited understanding exists about pediatric-onset HS, but with increasing prevalence of childhood obesity and awareness of HS, physicians may encounter younger HS patients more frequently.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Immunology
Kelly Z. Z. Young, Peter Dimitrion, Li Zhou, Indra Adrianto, Qing-Sheng Mi
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by abscesses, sinus tracts, and scarring. HS has a strong female sex bias, and this article reviews the role of intrinsic and extrinsic factors in sex-related differences in immunity and their potential role in HS pathophysiology. Hormones, X chromosome dosage, genetics, the microbiome, and smoking are discussed as possible factors contributing to sex-related differences in immunity and HS disease presentations.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biology
Agnieszka Nowak-Liduk, Diana Kitala, Gabriela Ochala-Gierek, Wojciech Labus, Beata Bergler-Czop, Kornelia Pietrauszka, Pawel Niemiec, Karol Szyluk, Marcin Gierek
Summary: Hidradenitis suppurativa, also known as acne inversa, is a chronic inflammatory disease that significantly affects the mental health and quality of life of patients. Although it has a relatively low prevalence, it disproportionately affects females. HS involving the female anogenital regions is rarely reported in gynecological literature, leading to misdiagnosis. It is associated with several comorbidities, including metabolic diseases and inflammatory bowel diseases. The exact etiology and pathogenesis are still unclear, but lifestyle, immune processes, genetics, and hormonal predispositions are believed to play a role in the development of chronic inflammation.
Article
Dermatology
Natalia Kirsten, Nicole Zander, Matthias Augustin
Summary: This study investigated the prevalence and cutaneous comorbidities of hidradenitis suppurativa in the German working population, finding a point prevalence of 0.3% and identifying non-inflammatory hidradenitis suppurativa-related lesions in 3.0% of individuals. Patients with hidradenitis suppurativa were significantly more likely to have acne vulgaris, psoriasis, and other skin conditions.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Article
Dermatology
Jurr Boer, Gregor B. E. Jemec
Summary: The mechanism behind the formation of localized patterns of inflammatory skin diseases such as Hidradenitis suppurtiva remains unclear, but it may be related to mechanical stress in intertriginous areas. The Koebner phenomenon describes the appearance of skin lesions following trauma, with striae distensae being a form of dermal scarring. The interaction between striae distensae and mechanical stress may provide a model for lesion development.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Genetics & Heredity
Bruna De Felice, Concetta Montanino, Marta Mallardo, Graziella Babino, Edi Mattera, Giovanni Ragozzino, Giuseppe Argenziano, Aurora Daniele, Ersilia Nigro
Summary: This study analysed the expression profiles of miRNA in the blood of HS patients and found significantly different expression of miR-24-1-5p, miR-146a-5p, miR26a-5p, miR-206, miR338-3p, and miR338-5p compared to healthy controls. MiR-338-5p was closely related to the invasiveness of HS lesions and cytokine production, showing atypical overexpression.
Article
Dermatology
Amit Garg, Neeta Malviya, Andrew Strunk, Shari Wright, Afsaneh Alavi, Raed Alhusayen, Ali Alikhan, Steven D. Daveluy, Isabelle Delorme, Noah Goldfarb, Wayne Gulliver, Iltefat Hamzavi, Tarannum Jaleel, Alexa B. Kimball, Joslyn S. Kirby, Mark G. Kirchhof, Janice Lester, Hadar Lev-Tov, Michelle A. Lowes, Robert Micheletti, Lauren A. Orenstein, Vincent Piguet, Christopher Sayed, Jerry Tan, Haley B. Naik
Summary: This study aims to provide evidence-based screening recommendations for comorbidities associated with HS. Screening recommendations were made based on the consistency and quality of existing studies, disease prevalence and magnitude of association, as well as benefits, harms, and feasibility of screening. A total of 30 comorbidities were recommended for screening in order to improve patients' quality of life and health status.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Rune Kjaersgaard Andersen, Isabella Charlotte Loft, Kristoffer Burgdorf, Christian Erikstrup, Ole B. Pedersen, Gregor B. E. Jemec
Summary: A study on symptoms of hidradenitis suppurativa in blood donors found an increased hazard ratio for antidepressants and analgesics in those reporting symptoms of the disease. Pain and depression were identified as the earliest comorbidities to present in the pathogenesis of the disease.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Dermatology
Aldo Morrone, Maria Lucia Dell'Anna, Antonio Cristaudo, Tewolde Wubayehu, Hagos Godefay, Gebre Ab Barnabas, Federica Dassoni, Valeska Padovese, Ottavio Latini, Torello Lotti, Pierluigi Saraceni, Enea Gino Di Domenico, Viviana Lora
Summary: This study conducted in Tigray, Ethiopia, found that plaque psoriasis is the most common form, with a 17% prevalence of psoriatic arthritis. In poorer rural areas, patients use traditional African plants for treatment. Further research on appropriate management and reducing costs of conventional drugs in low-income countries could benefit psoriasis care.
DERMATOLOGIC THERAPY
(2022)
Letter
Dermatology
Natalia Gennadievna Kalashnikova, Vera Igorevna Albanova, Mohammad Jafferany
DERMATOLOGIC THERAPY
(2021)
Letter
Dermatology
Bishurul Hafi, N. A. Uvais, Mohammad Jafferany, Razmi T. Muhammed, T. P. Afra, Abdulla M. Ameerali
DERMATOLOGIC THERAPY
(2021)
Editorial Material
Dermatology
Barbara Roque Ferreira, Mohammad Jafferany
Summary: This article discusses the limitations of current diagnostic classifications in psychodermatology and proposes a new classification system with three groups: primary psychodermatological disease, primary psychodermatological illness, and secondary psychodermatological disorder. The goal is to broaden the recognition of psychodermatology and improve patient management.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Review
Dermatology
Julio Torales, Joao Mauricio Castaldelli-Maia, Antonio Ventriglio, Jose Almiron-Santacruz, Ivan Barrios, Marcelo O'Higgins, Oscar Garcia, Rodrigo Navarro, Osvaldo Melgarejo, Mohammad Jafferany
Summary: AA is a complex illness with a multifactorial etiology involving genetic, autoimmune, hormonal, neural, and psychological factors. Research demonstrates a high comorbidity rate between AA and mental disorders, highlighting the role of stress and psychological factors in the development and exacerbation of the disease. Further evidence is needed to elucidate the associations between immune response, stress, and physiological factors in AA patients.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Letter
Dermatology
Erica L. Aukerman, Stacy Nakell, Mohammad Jafferany
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Anupam Das, Abheek Sil, Farhat Fatima, Indrashis Podder, Mohammad Jafferany
Summary: This study assessed the impact of chronic and recurrent dermatophytosis on quality of life and psychological well-being of patients. The results showed that chronic and recurrent dermatophytosis had a significant negative effect on patients' psychosocial well-being, including anxiety, depression, and perceived stress.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Letter
Dermatology
Ulas Guvenc, Belma Tursen, Torello Lotti, Umit Tursen, Olga Yu Olisova, Konstantin M. Lomonosov
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Letter
Dermatology
Abrahim Abduelmula, Syed Minhajur Rahman, Mohammad Jafferany
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Dermatology
Syed Minhaj Rahman, Abrahim Abduelmula, Mohammad Jafferany
Summary: Dermatological conditions and psychological health have a mutual impact. Psychopathological symptoms are associated with common skin disorders. Improving the diagnosis and providing appropriate psychological support is crucial for the treatment of dermatological conditions.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Rachel E. Christensen, Marie Schambach, Mohammad Jafferany
DERMATOLOGIC THERAPY
(2022)
Letter
Dermatology
Robabeh Abedini, Mohammad Jafferany, Azadeh Goodarzi, Mahshid Sadat Ansari, Mahsa Ansari, Sepehr Khosravi, Samaneh Mozafarpoor
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Dermatology
Sara Ait Oussous, Mohammad Jafferany, Radia Chakiri
Summary: This study is the first from North Africa to analyze the status of psychodermatology. Significant gaps were found in understanding, knowledge, and practice matters regarding psychodermatology. A psychodermatology curriculum should be included in training programs, and dermatology-psychiatry liaison is necessary to manage this patient population.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Letter
Dermatology
Olivia Katamanin, Mohammad Jafferany
CLINICS IN DERMATOLOGY
(2023)
Article
Dermatology
Mariabeatrice Bertolani, Eleonora Rodighiero, Roberta Saleri, Giuseppe Pedrazzi, Simona Bertoli, Alessandro Leone, Claudio Feliciani, Torello Lotti, Francesca Satolli
Summary: The study aimed to assess the association between the Mediterranean diet and IGF-1 in acne patients and examine the impact of systemic treatment on IGF-1 serum levels. The findings suggest that the Mediterranean diet may have a protective role in the pathogenesis of acne.
DERMATOLOGY REPORTS
(2022)
