Article
Cell Biology
Zhengying Yu, Haipeng Wang, Wanyi Tang, Shaoyang Wang, Xiaoying Tian, Yujie Zhu, Hao He
Summary: A new optical method, UPLaS, has been developed to precisely and noninvasively induce localized mitochondrial Ca2+ oscillations, which directly initiates the PINK1-Parkin pathway for mitophagy.
CELL DEATH & DISEASE
(2021)
Review
Neurosciences
Iryna Kamienieva, Jerzy Duszynski, Joanna Szczepanowska
Summary: The familial form of Parkinson's disease is linked to mutations in specific genes, with mutations in the parkin gene being one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, as mitochondria are highly dynamic structures integrated with many cellular functions.
TRANSLATIONAL NEURODEGENERATION
(2021)
Review
Cell Biology
Xiusheng Chen, Qi Wang, Shihua Li, Xiao-Jiang Li, Weili Yang
Summary: PINK1 is a mitochondrial kinase involved in mitophagy and neuronal protection. Mutations in PINK1 gene can cause early onset Parkinson's disease with mitochondrial dysfunction. Although there is evidence from in vitro studies supporting the role of PINK1 in regulating mitochondrial function, strong in vivo evidence is still lacking. Additionally, PINK1 has functions independent of mitochondria.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Siqi Liu, Chongyang Wang, Yulian Zhang, Yalin Zhang, Yilan Song, Jingzhi Jiang, Ruobai Liu, Hainan Jin, Guanghai Yan, Yongde Jin
Summary: Polydatin, derived from Polygonum cuspidatum, has been found to exert protective effects on allergic rhinitis (AR) by promoting PINK1-Parkin-mediated mitophagy, reducing mtROS production, inhibiting NLRP3 inflammasome activation, and suppressing apoptosis and tissue damage.
Article
Biochemistry & Molecular Biology
Can Li, Yuying Zhu, Weiwei Liu, Wendie Xiang, Sijun He, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima
Summary: This study focuses on the involvement of mitochondrial disorders in UVB-induced skin damages. UVB irradiation increases the amount of dysfunctional mitochondria in HaCaT cells, leading to decreased ATP production, mitochondrial membrane potential collapse, and apoptosis. The impairment of PINK1/parkin-mediated mitophagy contributes to UVB-induced cell damages by activating cGAS-STING pathway and promoting caspase-3-mediated apoptosis. Restoring mitophagy may be a potential strategy to protect skin from UVB damages.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Neurosciences
Tingting Yan, Yan Zhao, Zhongyu Jiang, Jiyang Chen
Summary: This study investigated the role of mitophagy in cytotoxicity induced by acetaldehyde, a toxic metabolite of ethanol. The findings showed that acetaldehyde treatment induced mitophagy and cytotoxicity in SH-SY5Y cells. The overactive mitophagy and oxidative stress were identified as important mechanisms contributing to acetaldehyde-induced cytotoxicity. Autophagy inhibitors and an antioxidant could alleviate the cytotoxic effects.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Toxicology
Beom Hee Kim, Hyun Chul Koh
Summary: CK2 regulates receptor-mediated mitophagy and is involved in PINK1/Parkin-dependent mitophagy. Whether CK2 regulates PINK1/Parkin-dependent mitophagy in response to stress is not yet clear.
TOXICOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Sisi Lei, Yuchao Feng, Peiying Huang, BoJun Chen, Kun Bao, Qihua Wu, Haobo Zhang, Xiaoyan Huang
Summary: The study suggests that OPD'-induced cardiomyocyte mitophagy and mitochondrial damage are at least partially mediated by dysregulation of the PINK1/Parkin pathway.
Review
Biochemistry & Molecular Biology
Ellen A. Goodall, Felix Kraus, J. Wade Harper
Summary: Selective autophagy plays a crucial role in maintaining cellular health by eliminating damaged or superfluous organelles and proteins through specific mechanisms. The attachment of ubiquitin to cargo is a common mechanism for initiating autophagy and a suite of ubiquitin-binding cargo receptors provide selectivity in cargo capture by recruiting the autophagosome initiation machinery. These emerging mechanisms shed light on how selectivity in cargo degradation is achieved in the field of autophagy research.
Article
Cell Biology
Takayuki Mito, Amy E. Vincent, Julie Faitg, Robert W. Taylor, Nahid A. Khan, Thomas G. McWilliams, Anu Suomalainen
Summary: The study finds that mitophagy plays a significant role in skeletal muscle mitochondrial dysfunction in aged mice and human patients. The progression of mitochondrial dysfunction interrupts mitophagy and disrupts lysosomal homeostasis. The mosaic halting of mitophagy may explain respiratory chain deficiency and accumulation of mtDNA variants in mitochondrial diseases and normal aging.
Article
Cell Biology
Lianzhi Mao, Huahuan Liu, Rongjun Zhang, Yudi Deng, Yuting Hao, Wenzhen Liao, Miaomiao Yuan, Suxia Sun
Summary: Warangalone was found to induce mitochondrial damage and decrease cell viability in breast cancer cells by increasing ROS production. Additionally, it activated mitophagy through upregulation of PINK1 and Parkin, leading to mitochondrial apoptosis. However, the protective effect of autophagy/mitophagy against Warangalone-induced mitochondrial apoptosis was also observed. In conclusion, a combination of Warangalone and autophagy/mitophagy inhibitors may be a potential treatment for breast cancer.
Article
Food Science & Technology
Jiehuan Xu, Lingwei Sun, Mengqian He, Shushan Zhang, Jun Gao, Caifeng Wu, Defu Zhang, Jianjun Dai
Summary: This study demonstrates that resveratrol can counteract the toxic effects of zearalenone during porcine oocyte maturation. Resveratrol improves mitochondrial dysfunction and damage by enhancing PINK1/Parkin-mediated mitophagy, thereby promoting embryonic development.
Article
Biochemistry & Molecular Biology
Paola Lenzi, Rosangela Ferese, Francesca Biagioni, Federica Fulceri, Carla L. Busceti, Alessandra Falleni, Stefano Gambardella, Alessandro Frati, Francesco Fornai
Summary: The study reveals that GBM cells exhibit mitochondrial alterations associated with mTOR overexpression and autophagy suppression, and the administration of mTOR inhibitor rapamycin can rescue these mitochondrial alterations. Rapamycin induces the expression of genes promoting mitophagy and mitochondrial fission, along with increased expression of VPS34, restoring healthy mitochondria in GBM cells. The findings provide novel evidence about mitochondria in GBM and suggest a potential therapeutic approach through mTOR inhibition to restore healthy mitochondria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qingtao Gao, Runyi Tian, Hailong Han, Jesse Slone, Caifang Wang, Xiao Ke, Tongmei Zhang, Xiangyu Li, Yuhong He, Panlin Liao, Fang Wang, Ye Chen, Shiqing Fu, Kexuan Zhang, Fangfang Zeng, Yingxuan Yang, Zhuo Li, Jieqiong Tan, Jiada Li, Youming Lu, Taosheng Huang, Zhonghua Hu, Zhuohua Zhang
Summary: This study reveals the importance of mitochondrial morphology and distribution in neural circuitry formation and synaptic efficacy and identifies the essential role of PINK1-Drp1(S616) phosphorylation coupling in regulating mitochondrial dynamics and neural circuitry formation.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Cell Biology
Qirong Xu, Sheng Liu, Qiang Gong, Rongrong Zhu, Jichun Liu, Qicai Wu, Xueliang Zhou
Summary: This study reveals that Notch1 protects against ischemic reperfusion injury by suppressing PTEN-Pink1-mediated mitochondrial dysfunction and fragmentation.
Article
Clinical Neurology
Rosalind F. Roberts, Richard Wade-Martins, Javier Alegre-Abarrategui
Editorial Material
Neurosciences
Rosalind F. Roberts, Richard Wade-Martins
EUROPEAN JOURNAL OF NEUROSCIENCE
(2016)
Review
Biochemistry & Molecular Biology
Rosalind F. Roberts, Matthew Y. Tang, Edward A. Fon, Thomas M. Durcan
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2016)
Review
Clinical Neurology
Javier Alegre-Abarrategui, Katherine R. Brimblecombe, Rosalind F. Roberts, Elisavet Velentza-Almpani, Bension S. Tilley, Nora Bengoa-Vergniory, Christos Proukakis
ACTA NEUROPATHOLOGICA
(2019)
Review
Clinical Neurology
Nora Bengoa-Vergniory, Rosalind F. Roberts, Richard Wade-Martins, Javier Alegre-Abarrategui
ACTA NEUROPATHOLOGICA
(2017)
