Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 54, Issue -, Pages 119-126Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2020.01.018
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Funding
- Chan Zuckerberg Biohub Microbiome Initiative at Stanford University
- Thomas C. and Joan M. Merigan Endowment at Stanford University
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Relationships between hosts and host-associated microbial communities are complex, intimate, and associated with a wide variety of health and disease states. For these reasons, these relationships have raised many difficult questions and claims about microbiome causation. While philosophers and scientists alike have pondered the challenges of causal inference and offered postulates and rules, there are no simple solutions, especially with poorly characterized, putative causal factors such as microbiomes, ill-defined host effects, and inadequate experimental models. Recommendations are provided here for conceptual and experimental approaches regarding microbiome causal inference, and for a research agenda.
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