Journal
CURRENT MOLECULAR MEDICINE
Volume 20, Issue 9, Pages 667-674Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1566524020666200226124336
Keywords
microRNAs; chemotherapy; multidrug resistance; gastric cancer; mechanisms; MDR
Categories
Funding
- National Natural Science Foundation of China [81570783]
- National Key R&D Program of China [2016YFC1302201]
- Key Program of the Natural Science Foundation of Gansu Province, China [18JR3RA366]
- Open Fund of Key Laboratory for Gastrointestinal Diseases of Gansu Province, China [gswcky-2013-006]
- Excellence Program of the First Clinical Medical College of Lanzhou University, China
Ask authors/readers for more resources
Multidrug resistance (MDR) is one of the most significant reasons for the chemotherapeutics failure in gastric cancer. Although accumulating investigations and researches have been made to elucidate the mechanisms of multidrug resistance, the detail is far from completely understood. The importance of microRNAs in cancer chemotherapeutic resistance has been demonstrated recently, which provides a new strategy to overcome multidrug resistance. The different mechanisms are related to the phenomena of MDR itself and the roles of miRNAs in these multi-mechanisms by which MDR is acquired. In turn, the aim of this review was to summarize recent publications of microRNAs in regulating MDR in gastric cancer, thereby potentially developing as targeted therapies. Further unraveling the roles of microRNAs in MDR mechanisms including the ATP-binding cassette (ABC) transporter family, autophagy induction, cancer stem cell regulation, hypoxia induction, DNA damage and repair, epigenetic regulation, and exosomes in gastric cancer will be helpful for us to win the battle against it.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available