The Impact of Neutral Mutations on Genome Evolvability

Beneficial mutations are rare and deleterious mutations are purged by natural selection. As a result, the vast majority of mutations that accumulate in genomes belong to the class of neutral mutations. Over the last two decades, neutral mutations, despite their null effect on fitness, have been shown to affect evolvability by providing access to new phenotypes through subsequent mutations that would not have been available otherwise. Here we propose that in addition, many mutations - independent of their selective effects can affect the mutability of neighboring DNA sequences and modulate the efficacy of homologous recombination. Such mutations do not change the spectrum of accessible phenotypes, but rather the rate at which new phenotypes will be produced. Therefore, neutral mutations that accumulate in genomes have an important long-term impact on the evolutionary fate of genomes.