Review
Pharmacology & Pharmacy
Pratima Kumari, Priyanka Debta, Anshuman Dixit
Summary: Oral cancer is a critical health issue, with the majority of new cases occurring in Asia. Various factors, such as genetics and lifestyle, are closely associated with its occurrence and progression. Early signs of oral cancer include oral lesions, genetic mutations, and viral infections. Lesions with dysplastic features have a high risk of malignancy, and OPMDs have a high prevalence in South Asian countries. Early detection, prevention, and treatment of OPMDs are crucial.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Saman Warnakulasuriya, Omar Kujan, Jose M. Aguirre-Urizar, Jose Bagan, Miguel Angel Gonzalez-Moles, Alexander R. Kerr, Giovanni Lodi, Fernanda Weber Mello, Luis Monteiro, Graham R. Ogden, Philip Sloan, Newell W. Johnson
Summary: Oral potentially malignant disorders (OPMDs) are associated with an increased risk of oral cancer, and an expert group updated the nomenclature and classification of OPMDs, adding oral lichenoid lesions and oral manifestations of 'chronic graft-versus-host disease' to the list. It is recommended to establish a global research consortium to study the natural history of OPMDs based on the proposed classification.
Article
Otorhinolaryngology
Marko Tarle, Danko Muller, Marina Raguz, Ivica Luksic
Summary: This study investigated the expression of nuclear EGFR (nEGFR) and the stem cell marker ABCG2 in oral leukoplakia and oral erythroplakia, and found that co-expression of both biomarkers was associated with an increased risk of malignant transformation.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Medicine, General & Internal
Sheng-Fu Chiu, Chung-Han Ho, Yi-Chen Chen, Li-Wha Wu, Yuh-Ling Chen, Jer-Horng Wu, Wei-Sheng Wu, Hui-Kun Hung, Wei-Fan Chiang
Summary: The study aimed to analyze the malignant transformation rate of oral potentially malignant disorders (OPMDs) and found that oral verrucous hyperplasia (OVH) had the highest malignant transformation possibility, with female OPMD patients having a relatively high malignant transformation rate.
Article
Engineering, Biomedical
Xing Wang, Zuoying Yuan, Anqi Tao, Pudi Wang, Wenyue Xie, Shuo Yang, Jianyong Huang, Ning Wen
Summary: This study introduces a novel hydrogel patch that effectively treats oral potentially malignant disorders and improves patient comfort. Through experiments and modeling, the feasibility and clinical value of this hydrogel patch have been demonstrated.
Article
Dentistry, Oral Surgery & Medicine
Gerardo Gilligan, Rene Panico, Jeronimo Lazos, Rosana Morelatto, Paola Belardinelli, Ines Criscuolo, Nicolas Bolesina, Ignacio Molina Avila, Juan Martin Pimentel Sola, Emilce Rivarola, Maria Jimena Morgante, Maria Eugenia Ingrassia Tonelli, Javier Gimenez, Pablo Doratti, Laura Cecilia Werner, Ana Carolina Prado-Ribeiro, Thais Bianca Brandao, Aljomar Jose Vechiato-Filho, Maria Claudia Cuzzullin, Cristina Saldivia-Siracusa, Marcio Ajudarte Lopes, Michelle Agostini, Mario Jose Romanach, Aline Correa Abrahao, Thamyres Campos Fonseca, Estela Kaminagakura, Ana Lia Anbinder, Kamilla Santos Alves, Maria Leticia de Almeida Lanca, Sonia Sacsaquispe-Contreras, Karem Rodriguez Ibazetta, Roberto Gerber-Mora, Saray Aranda Romo, Francisco Javier Tejeda Nava, Karina Cordero-Torres, Ricardo Moreno Silva, Wilfredo Gonzalez-Arriagada, Raiza Toro, Felipe Martins Silveira, Natalia Gonzalez, Pablo Agustin Vargas, Alan Roger Santos-Silva, Ronell Bologna-Molina, Mariana Villarroel-Dorrego, Benjamin Martinez, Eduardo Piemonte
Summary: This study aims to investigate the frequency, epidemiological profile, and traditional risk factors of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD) in Latin America. The results suggest that OSCC-dn is more frequent in Latin America, with regional variations in some clinical and histopathological features.
Review
Biochemistry & Molecular Biology
Nadia Kaunein, Rishi Sanjay Ramani, Kendrick Koo, Caroline Moore, Antonio Celentano, Michael McCullough, Tami Yap
Summary: Oral cancer is the eighth most common cancer worldwide, and early diagnosis and management of oral potentially malignant disorders are crucial for reducing deaths and improving prognosis. Research indicates that miRNAs play a critical role in the initiation and progression of oral cancer, with significant potential in predicting malignant transformation of potentially malignant disorders.
Article
Biochemistry & Molecular Biology
Lucas de Villalain, Saul Alvarez-Teijeiro, Tania Rodriguez-Santamarta, Alvaro Fernandez del Valle, Eva Allonca, Juan P. Rodrigo, Juan Carlos de Vicente, Juana M. Garcia-Pedrero
Summary: This study aimed to evaluate the expression of senescence markers DcR2 and DEC1 in oral potentially malignant disorders and found a significant association with oral cancer risk. The increased expression of DcR2 and DEC1 was correlated with increased risk of oral cancer and higher-grade dysplasia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Pablo Ramos-Garcia, Maria del Mar Roca-Rodriguez, Manuel Aguilar-Diosdado, Miguel Angel Gonzalez-Moles
Summary: The study revealed that patients with diabetes mellitus have a higher prevalence and greater chance of developing oral cancer and potentially malignant oral disorders compared to non-diabetic patients, with higher mortality rates for diabetic patients with oral cancer.
Review
Dentistry, Oral Surgery & Medicine
Cecilie D. de la Cour, Cecilie D. Sperling, Federica Belmonte, Stina Syrjanen, Susanne K. Kjaer
Summary: The study aimed to provide pooled estimates of HPV prevalence in oral potentially malignant disorders and found an overall HPV prevalence of 22.5% with significant heterogeneity between studies. The prevalence appeared to be similar across subgroups and independent of epithelial dysplasia.
Article
Oncology
Ya-Qin Tan, Zheng-Tao Li, Gang Zhou
Summary: Oral potentially malignant disorders (OPMDs) are associated with an increased risk of oral cavity or lip cancers. The primary objective of OPMDs management is to prevent cancer development. Current strategies for OPMDs management include non-surgical and surgical interventions, disease monitoring, and preventive strategies. However, there is a need for improved treatment options and predictive markers for OPMDs treatment.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
John Adeoye, Mohamad Koohi-Moghadam, Anthony Wing Ip Lo, Raymond King-Yin Tsang, Velda Ling Yu Chow, Li-Wu Zheng, Siu-Wai Choi, Peter Thomson, Yu-Xiong Su
Summary: Machine learning models were used to predict malignancy from oral white lesions with satisfactory performance and stability. DeepSurv and RSF were the top-performing models in terms of discrimination and calibration in internal validation. DeepSurv was more stable than RSF in cross-validation, with external validation confirming their utility for discrimination and individual survival estimates.
Article
Biochemistry & Molecular Biology
Alejandro Herreros-Pomares, David Hervas, Leticia Bagan-Debon, Eloisa Jantus-Lewintre, Concepcion Gimeno-Cardona, Jose Bagan
Summary: This study aims to compare and describe the composition and diversity of the oral microbiome in patients with homogeneous leucoplakia, proliferative verrucous leukoplakia, oral squamous cell carcinoma, and OSCC preceded by PVL. The number of bacterial species was lower in cancer patients, with Fusobacteriota being the dominant group. PVL and PVL-OSCC patients had a higher abundance of Campilobacterota and lower Proteobacteria compared to other groups. This is the first study comparing oral microbiome alterations in these groups, and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xinjia Cai, Jianyun Zhang, Ying Han, Qian Tang, Heyu Zhang, Tiejun Li
Summary: This study developed a novel nomogram model to assess the risks of malignant transformation of oral potentially malignant disorders. The model showed high predictive value and clinical relevance, although not applicable to all cases.
Review
Oncology
Yan Huang, Qiufang Zhang, Zhenzhen Guo, Guanhong Deng, Ruibin Chen, Yanfen Zheng
Summary: This study systematically searched and analyzed the literature on potential saliva and serum biomarkers for oral leukoplakia (OL) malignant transformation. The results showed that IL-6 and TNF-alpha in saliva, as well as LSA and TSA levels in serum, have statistically significant differences in distinguishing healthy controls, OL patients, and oral cancer patients.
Article
Dentistry, Oral Surgery & Medicine
Bubacar Embalo, Andressa Fernanda Paza Miguel, Andrea Cristina Konrath, Filipe Modolo, Elena Riet Correa Rivero
Review
Dentistry, Oral Surgery & Medicine
Teresa De Porras-Carrique, Pablo Ramos-Garcia, Manuel Aguilar-Diosdado, Saman Warnakulasuriya, Miguel Angel Gonzalez-Moles
Summary: There is a high prevalence and frequent association between OLP and autoimmune disorders, especially thyroid disease and diabetes mellitus.
Review
Dentistry, Oral Surgery & Medicine
Larissa Di Carvalho Melo, Bruna Bastos Silveira, Juliana Amorim dos Santos, Jessica Alves de Cena, Naile Dame-Teixeira, Manoela Domingues Martins, Graziela De Luca Canto, Eliete Neves Silva Guerra
Summary: This scoping review examines the frequency of different teaching methodologies, tools, and platforms used in dental education during the COVID-19 pandemic. The findings suggest that e-learning technologies have the potential to contribute significantly to dental education during this time. Blended teaching methods, using a combination of synchronous and asynchronous formats, are common, and Zoom, Microsoft Teams, and Cisco Webex are popular platforms. The advantages of dental e-learning include better time management and the ability to review with additional notes, while increased anxiety, stress, burnout, exhaustion, and internet connection problems are common disadvantages.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2023)
Review
Public, Environmental & Occupational Health
Adalberto M. Filho, Michelle C. Turner, Saman Warnakulasuriya, David B. Richardson, Bayan Hosseini, Farin Kamangar, Akram Pourshams, Vikash Sewram, Deirdre Cronin-Fenton, Arash Etemadi, Deborah C. Glass, Afarin Rahimi-Movaghar, Mahdi Sheikh, Reza Malekzadeh, Mary K. Schubauer-Berigan
Summary: The International Agency for Research on Cancer (IARC) recently evaluated the carcinogenicity of opium consumption. This study conducted an extended systematic review and meta-analysis to assess the relationship between opium consumption and selected cancers. The findings provide robust evidence of an adverse association between opium consumption and cancers of the urinary bladder, larynx, lung, esophagus, pancreas, and stomach.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gabriel Leonardo Magrin, Leticia Daros Scarduelli, Elena Riet Correa Rivero, Ricardo de Souza Magini, Reinhard Gruber, Cesar Augusto Magalhaes Benfatti
Summary: The purpose of this study was to compare different socket sealing approaches for alveolar ridge preservation and assess the dimensional changes and histologic characteristics of soft and hard tissues in a 4- to 6-month period. The results showed that there was no difference in the effects on volumetric maintenance and tissue formation among the sealing approaches.
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Lucas Lacerda de Souza, Felipe Paiva Fonseca, Anna Luiza Damaceno Araujo, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Syed Ali Khurram, Luiz Paulo Kowalski, Harim Tavares dos Santos, Saman Warnakulasuriya, James Dolezal, Alexander. T. T. Pearson, Alan Roger Santos-Silva
Summary: Oral potentially malignant disorders are precursor lesions with the potential to transform into oral cancer. Risk factors contribute to the development of these disorders and the risk of malignant transformation. Early diagnosis is crucial for improving prognosis, and the integration of machine learning into clinical examination has shown promise in the detection of early cancer.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Letter
Oncology
Saman Warnakulasuriya
Article
Dentistry, Oral Surgery & Medicine
Andressa Fernanda Paza Miguel, Andre Goulart Poletto, Bubacar Embalo, Elena Riet Correa Rivero
Summary: This study aimed to investigate the correlation between the immunoexpression of epithelial-mesenchymal transition markers and putative markers with clinical and histologic parameters of oral epithelial dysplasia. The results showed that PDPN was associated with high-risk epithelial dysplasia and loss of E-CAD expression, while IL-6 may have a shared regulatory mechanism with OTPN expression.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
G. Melo, E. A. Batistella, J. V. S. Bett, L. J. Grando, E. R. C. Rivero
Summary: This study assessed the prevalence of maxillofacial lesions in children and adolescents in a Brazilian Oral Pathology Service and compared it with the available literature. The results showed that reactive salivary gland lesions and reactive connective tissue lesions were the most common soft tissue lesions, affecting children and adolescents equally. Odontogenic cysts and periapical inflammatory lesions were the most prevalent intraosseous lesions, with no significant differences between age groups, except for the odontogenic keratocyst, which was more common in adolescents. Some odontogenic tumors, such as ameloblastic fibroma and odontogenic myxoma, were significantly more common in children.
EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Irosha Perera, Hemantha Amarasinghe, Ruwan D. Jayasinghe, Iresha Udayamalee, Nadeena Jayasuriya, Saman Warnakulasuriya, Newell W. Johnson
Summary: Oral cancer is the most common malignancy among Sri Lankan males and a top 10 cancer among females. Despite being preventable and controllable, contextual factors and social determinants consistently hinder progress in addressing oral cancer inequalities. This review aims to critically analyze oral cancer epidemiology and inequalities in Sri Lanka, using multiple data sources.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Saman Warnakulasuriya
Article
Dentistry, Oral Surgery & Medicine
Elis Angela Batistella, Andressa Fernanda Paza Miguel, Nicole Lonni Nascimento, Martinho Campolina Rebello Horta, Daniella Serafin Couto Vieira, Elena Correa Riet Rivero
Summary: The role of blood and lymphatic microvascular density in the progression of oral squamous cell carcinoma (OSCC) was investigated in this study. It was found that the expression of anti-alpha-smooth muscle actin (a-SMA) and anti-endoglin (CD105) was associated with microvessel density (MVD), while anti-podoplanin (D2-40) was associated with lymphatic vessel density (LVD). Furthermore, high tumour budding (TB) and tumour thickness were identified as risk factors for OSCC progression and worse patient outcomes.
Review
Medicine, General & Internal
Kalpani Senevirathna, Roshan Pradeep, Yovanthi Anurangi Jayasinghe, Shalindu Malshan Jayawickrama, Rasika Illeperuma, Saman Warnakulasuriya, Ruwan Duminda Jayasinghe
Summary: Oral cancers are common in Southeast Asia due to the habit of betel quid and smokeless tobacco use. Areca nut, the main ingredient in betel quid, contains alkaloids that have been associated with addiction and carcinogenicity. Recent studies have shown cellular and molecular effects induced by areca nut, including promoting epithelial-mesenchymal transition, autophagy initiation, tissue hypoxia, genotoxicity, cytotoxicity, and cell death. Clinical research also supports these harmful effects. The carcinogenicity of areca nut based on experimental studies is discussed in this review.
CLINICS AND PRACTICE
(2023)
Article
Pathology
Laura Borges Kirschnick, Lauren Frenzel Schuch, Rogerio Gondak, Elena Riet Correa Rivero, Ana Paula Neutzling Gomes, Adriana Etges, Sandra Beatriz Chaves Tarquinio, Ricardo Alves Mesquita, Patricia Carlos Caldeira, Adriana Aparecida Silva da Costa, Elismauro Francisco Mendonca, Jean Nunes dos Santos, Chane Smit, Liam Robinson, Elena Maria Jose Roman Tager, Adalberto Mosqueda-Taylor, Helder Antonio Rebelo Pontes, Bruno Augusto Benevenuto de Andrade, Thamyres Campos Fonseca, Aline Correa Abrahao, Michelle Agostini, Mario Jose Romanach, Fabio Abreu Alves, Graziella Chagas Jaguar, Nathalia Felix de Mendonca, Mariana Bitu Ramos Pinto, Luan Cesar da Silva, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Willie van Heerden, Lucas Guimaraes Abreu, Manoela Domingues Martins, Ana Carolina Uchoa Vasconcelos
Summary: This study investigated the clinicopathological features of metastases in the oral and maxillofacial regions. The most frequent lesions were intraosseous, with breast cancer as the most common primary tumor location in females and lung origin in males. Clinicians should be aware that any oral lesions have the possibility of being metastatic, particularly in individuals with a previous history of cancer.
HEAD & NECK PATHOLOGY
(2023)
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
