How visual perspective influences the spatiotemporal dynamics of autobiographical memory retrieval

Visual perspective, recalling events from one's own eyes or one of several possible observer viewpoints, is a fundamental aspect of AM. Yet, exactly how visual perspective influences the functional mechanisms supporting retrieval is unclear. Here we used a multivariate analysis to characterize the spatiotemporal dynamics of networks supporting AM retrieval from multiple typical and atypical visual perspectives. Both own eyes and observer perspectives engaged an AM retrieval network (i.e., hippocampus, anterior and posterior midline, and lateral frontal and posterior cortices) that peaked during later retrieval periods, but was recruited less strongly for observer perspectives. Functional connectivity analyses with an anterior hippocampal seed revealed that visual perspective also affected the strength and timing of neural recruitment. There was stronger hippocampal connectivity with a posterior medial network during the initial retrieval of AMs from atypical observer perspectives and stronger within-MTL and ventromedial prefrontal cortex connectivity during later retrieval periods from own eyes perspectives, suggesting that visual perspective is an important factor in understanding how neocortical systems guide memory retrieval. Our findings demonstrate that adopting own eyes and observer perspectives during AM retrieval is correlated with distinct patterns of hippocampal-neocortical interactions associated with differential recruitment of the AM retrieval network during later retrieval periods, thereby supporting the central role of visual perspective in reconstructing the personal past. (c) 2020 Elsevier Ltd. All rights reserved.