A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity

Histone Deacetylase 6 Represents a Novel Drug Target in the Oncogenic Hedgehog Signaling Pathway

(2015) P. K. Dhanyamraju et al.   MOLECULAR CANCER THERAPEUTICS

Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in Medulloblastoma

(2015) Enrico De Smaele et al.   NEOPLASIA

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1

(2014) Victoria E. Villegas et al.   Molecular Oncology

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

(2014) Hiba Ahmad Zahreddine et al.   NATURE

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat

(2014) Katrina J Falkenberg et al.   Scientific Data

A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells

(2013) Fabio Petrocca et al.   CANCER CELL

A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors

(2013) M New et al.   CELL DEATH AND DIFFERENTIATION

A Targeted RNAi Screen of the Breast Cancer Genome Identifies KIF14 and TLN1 as Genes That Modulate Docetaxel Chemosensitivity in Triple-Negative Breast Cancer

(2013) S. M. Singel et al.   CLINICAL CANCER RESEARCH

Cyclopamine, a Naturally Occurring Alkaloid, and Its Analogues May Find Wide Applications in Cancer Therapy

(2013) Haikuo Ma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation

(2013) Anita T. Tandle et al.   EUROPEAN JOURNAL OF CANCER

Nonclassical hedgehog-gli signaling and its clinical implications

(2013) Lalita A. Shevde et al.   INTERNATIONAL JOURNAL OF CANCER

Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition

(2013) Shamik Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine

(2013) J. Fredebohm et al.   JOURNAL OF CELL SCIENCE

Menin Directly Represses Gli1 Expression Independent of Canonical Hedgehog Signaling

(2013) Buddha Gurung et al.   MOLECULAR CANCER RESEARCH

A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer

(2013) S Postel-Vinay et al.   ONCOGENE

HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses

(2013) J E Bolden et al.   Cell Death & Disease

Gli family transcription factors are drivers of patupilone resistance in ovarian cancer

(2012) Simona Mozzetti et al.   BIOCHEMICAL PHARMACOLOGY

GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft

(2012) Junsheng Fu et al.   CANCER LETTERS

Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway

(2012) B. Ramaswamy et al.   CANCER RESEARCH

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growthin vitroandin vivo

(2012) Malin Wickström et al.   INTERNATIONAL JOURNAL OF CANCER

Smoothened Antagonists Reverse Taxane Resistance in Ovarian Cancer

(2012) A. D. Steg et al.   MOLECULAR CANCER THERAPEUTICS

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Hedgehog pathway as a drug target: Smoothened inhibitors in development

(2012) Tara Lin et al.   OncoTargets and Therapy

A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

(2012) Li Xie et al.   PLoS Genetics

Hedgehog Inhibition With the Orally Bioavailable Smo Antagonist LDE225 Represses Tumor Growth and Prolongs Survival in a Transgenic Mouse Model of Islet Cell Neoplasms

(2011) Volker Fendrich et al.   ANNALS OF SURGERY

Deciphering the Molecular Events Necessary for Synergistic Tumor Cell Apoptosis Mediated by the Histone Deacetylase Inhibitor Vorinostat and the BH3 Mimetic ABT-737

(2011) A. P. Wiegmans et al.   CANCER RESEARCH

Sonic Hedgehog Signaling Protects Human Hepatocellular Carcinoma Cells Against Ionizing Radiation in an Autocrine Manner

(2011) Yu-Jen Chen et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma

(2011) R R Singh et al.   ONCOGENE

Correlation of Hedgehog Signal Activation with Chemoradiotherapy Sensitivity and Survival in Esophageal Squamous Cell Carcinomas

(2010) W. Zhu et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy

(2010) O. Khan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Genome-wide Loss-of-Function Screen Reveals an Important Role for the Proteasome in HDAC Inhibitor-Induced Apoptosis

(2009) Susan Fotheringham et al.   CANCER CELL

Candidate Biomarkers of Response to an Experimental Cancer Drug Identified through a Large-scale RNA Interference Genetic Screen

(2009) J. Mullenders et al.   CLINICAL CANCER RESEARCH

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

Gli1 is a potential target for alleviating multidrug resistance of gliomas

(2009) Daming Cui et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

An Intermittent Live Cell Imaging Screen for siRNA Enhancers and Suppressors of a Kinesin-5 Inhibitor

(2009) Melody Tsui et al.   PLoS One

Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma

(2008) V. R. Fantin et al.   CANCER RESEARCH