Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yaqun Jiang, Bing Wen, Chongjiao Li, Yueli Tian, Zhiwei Xiao, Kui Xu, Diankui Xing, Zili Yu, Jing Huang, Jun Jia, Yong He
Summary: This study compares the performance of Ga-68-FAPI-04 and F-18-FDG PET/CT in the staging and detection of recurrences in head and neck squamous cell carcinoma (HNSCC). The results showed that Ga-68-FAPI-04 PET/CT outperformed F-18-FDG PET/CT in evaluating preoperative N staging and detecting distant metastasis. It also showed potential in clinical management and monitoring treatment response.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Ding, Jiangdong Qiu, Zhixin Hao, Hua Huang, Qiaofei Liu, Wenjing Liu, Chao Ren, Marcus Hacker, Taiping Zhang, Wenming Wu, Xiang Li, Li Huo
Summary: This study evaluated the performance of [(68) Ga]Ga-FAPI-04 and [F-18]F-FDG PET/CT on the disease staging and prognostic value of patients with localized PDAC. The results showed that [(68) Ga]Ga-FAPI-04 was more sensitive and accurate than [F-18]F-FDG, and could be used for staging and prognostic evaluation of PDAC, providing a non-invasive guide for clinical management.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin Zhou, Shuailiang Wang, Xiaoxia Xu, Xiangxi Meng, Huiyuan Zhang, Annan Zhang, Yufei Song, Hua Zhu, Zhi Yang, Nan Li
Summary: This study compared the clinical staging performance of [(68) Ga]Ga-DOTA-FAPI-04 PET/CT and 2-[F-18]FDG PET/CT in non-small cell lung cancer (NSCLC) patients. The results showed that [(68) Ga]Ga-DOTA-FAPI-04 PET/CT had better staging performance in NSCLC patients, especially in localized disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jiayu Cai, Weizhi Xu, Tinghua Meng, YiZhen Pang, Haojun Chen
Summary: Mixed neuroendocrine carcinoma-acinar carcinoma is a rare type of neuroendocrine prostate cancer and has rarely been reported in de novo cases. In this case, we present the PET/CT findings of Ga-68-PSMA, Ga-68-FAPI, and F-18-FDG in the de novo form of mixed large-cell neuroendocrine carcinoma-acinar adenocarcinoma of the prostate. Different levels of radiotracer uptake were observed in metastatic sites on Ga-68-PSMA, Ga-68-FAPI, and F-18-FDG PET/CT. This case demonstrates the potential use of a multitracer PET/CT strategy for noninvasive detection of intermetastatic heterogeneity in metastatic neuroendocrine prostate cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ihsan Kaplan, Canan Can, Yunus Guzel, Ulas Alabalik, Halil Komek
Summary: F-18-FDG PET/CT and Ga-68-FAPI 04 PET/CT were used for restaging in a 16-year-old boy with malignant mixed germ cell tumor. Results showed that Ga-68-FAPI-04 PET/CT was superior to F-18-FDG PET/CT in the evaluation of metastases in the testicular tumor.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peipei Wang, Chen Li, Guozhu Hou, Zhaohui Li, Hongli Jing, Wen Zhang, Fang Li
Summary: The study demonstrates that PET/CT is useful in evaluating patients with SAPHO syndrome, a rare inflammatory disorder affecting bone, joints, and skin.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Medicine, General & Internal
Daniela Prosperi, Luciano Carideo, Vincenzo Marcello Russo, Rosaria Meucci, Giuseppe Campagna, Secondo Lastoria, Alberto Signore
Summary: Pulmonary carcinoids (PCs) are neuroendocrine neoplasms that can be classified as typical or atypical. The combination of Ga-68-SSA PET/CT and [F-18]FDG PET/CT is essential for the correct management of these tumors, with [F-18]FDG playing a particularly important role in the clinical practice of aggressive atypical carcinoids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Chen, Kui Xu, Chongjiao Li, Yueli Tian, Ling Li, Bing Wen, Can He, Hongbing Cai, Yong He
Summary: [Ga-68]Ga-FAPI-04 PET/CT achieves higher sensitivity than [F-18]F-FDG PET/CT in the detection and diagnosis of lymph node and peritoneal metastases in epithelial ovarian cancer (EOC), suggesting advantages regarding the preoperative staging of patients with EOC and, thereby, improving treatment decision-making.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Goksel Alcin, Esra Arslan, Tamer Aksoy, Merve Cin, Ozge Erol Fenercioglu, Ediz Beyhan, Nurhan Ergul, Tevfik Fikret Cermik
Summary: In this study, the PET findings of F-18-FDG PET/CT were compared with Ga-68-FAPI-04 PET/CT findings in breast cancer patients with low F-18-FDG uptake. The results showed that Ga-68-FAPI-04 PET/CT has higher sensitivity in detecting primary tumors and provides higher SUVmax values. Additionally, this method can contribute to increased detection of lymph node involvement and aid in patient management.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haojun Chen, Liang Zhao, Dan Ruan, Yizhen Pang, Bing Hao, Yaqing Dai, Xiurong Wu, Wei Guo, Chunlei Fan, Jingxun Wu, Weipeng Huang, Qin Lin, Long Sun, Hua Wu
Summary: This prospective study evaluated the potential usefulness of [Ga-68]Ga-DOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) in oncological evaluation of patients with inconclusive [F-18]FDG PET/CT findings. The study found that [Ga-68]Ga-DOTA-FAPI-04 may have a complementary role in discriminating mass lesions on conventional imaging, locating unknown primary sites in biopsy-proven metastatic malignancy, modifying tumor staging, and detecting suspected disease recurrence. However, caution should be exercised when interpreting [Ga-68]Ga-DOTA-FAPI-04 PET/CT images in tumors complicated with inflammation.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rong Lin, Zefang Lin, Zhenying Chen, Shan Zheng, Jiaying Zhang, Jie Zang, Weibing Miao
Summary: This study compared the performance of [Ga-68]Ga-DOTA-FAPI-04 and [F-18]FDG PET/CT in evaluating gastric cancer. The results showed that [Ga-68]Ga-DOTA-FAPI-04 PET/CT outperformed [F-18]FDG PET/CT in detecting peritoneal, abdominal lymph node, and bone metastases. Additionally, [Ga-68]Ga-DOTA-FAPI-04 PET/CT provided more valuable information for patients with recurrent disease and had the potential in monitoring treatment response.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Orthopedics
Yiqun Wang, Yu Li, Liang Han, Jun Wang, Cong Zhang, Erpeng Qi, Dongyun Zhang, Xiaojun Zhang, Yong Huan, Jiahe Tian
Summary: In this study, a joint replacement loosening model was established and the performance characteristics of F-18-FDG and (68) Ga-FAPI in evaluating infection and loosening were evaluated. The results showed that (68) Ga-FAPI had greater sensitivity in detecting diseases compared to F-18-FDG and had the potential to define the scope of lesions more accurately. However, the SUVmax of (68) Ga-FAPI could not accurately differentiate between loosening and infection.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Oncology
Huipan Liu, Zhi Hu, Xiao Yang, Tianyang Dai, Yue Chen
Summary: The study found that [Ga-68]Ga-DOTA-FAPI-04 PET/CT has better diagnostic performance in detecting primary and metastatic lesions of esophageal cancer compared to [F-18]FDG PET/CT. The technology showed higher accuracy in detecting lesions in treatment-naive patients and had higher sensitivity for primary tumors, lymph nodes, and bone and visceral metastases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bingxin Gu, Xin Liu, Shuoer Wang, Xiaoping Xu, Xiaosheng Liu, Silong Hu, Wangjun Yan, Zhiguo Luo, Shaoli Song
Summary: This study evaluated the diagnostic value of [(68)Ga]Ga-DOTA-FAPI-04 PET/CT for recurrent soft tissue sarcoma (STS) and compared it with [F-18]FDG PET/CT. The results showed that [(68)Ga]Ga-DOTA-FAPI-04 PET/CT was more accurate than [F-18]FDG PET/CT in detecting recurrent lesions of liposarcoma, MSFT, and IDCS.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Letter
Rheumatology
Martin Sebastian Winkler, Peter Korsten, Claudia Binder, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Oncology
Yi Liao, Senmao Li, Hao Chen, Chunyu Chen, Jintuan Huang, Feng Lin, Jianping Wang, Zuli Yang
Summary: A risk prediction system combining FIT and risk factors was developed to improve the sensitivity of colonoscopy screening. The system effectively stratified participants into high risk and low risk groups, with better predictive ability for colorectal neoplasia compared to using FIT alone.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Luca Giraldi, Jovana Stojanovic, Dario Arzani, Roberto Persiani, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Carlo La Vecchia, Claudio Pelucchi, Nuno Lunet, Ana Ferro, Reza Malekzadeh, Joshua Muscat, David Zaridze, Dmitry Maximovich, Nuria Aragones, Vicente Martin, Jesus Vioque, Eva M. Navarrete-Munoz, Mohammadreza Pakseresht, Eva Negri, Matteo Rota, Farhad Pourfarzi, Lina Mu, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Roberta Pastorino, Stefania Boccia
Summary: This study aimed to examine the association between height and risk of gastric cancer. Through a large pooled analysis of case-control studies, the study found no significant association between adult height and gastric cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Maria A. Karalexi, Marina Servitzoglou, Vassilios Papadakis, Denis Kachanov, Maja Cesen Mazic, Margaret Baka, Maria Moschovi, Maria Kourti, Sofia Polychronopoulou, Eftichia Stiakaki, Emmanuel Hatzipantelis, Helen Dana, Kalliopi Stefanaki, Astero Malama, Marios S. Themistocleous, Katerina Strantzia, Tatyana Shamanskaya, Panagiota Bouka, Paraskevi Panagopoulou, Maria Kantzanou, Evangelia Ntzani, Nick Dessypris, Eleni Th. Petridou
Summary: The prognosis of children with neuroblastoma varies depending on the stage and biology of the tumor, and early-stage neuroblastoma has a better prognosis. Treatment with anti-GD2 antibody can improve the prognosis of high-risk patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Review
Clinical Neurology
Christoph Eckhard Heyde, Ulrich Josef Albert Spiegl, Anna Voelker, Nicolas von der Hoeh, Jeanette Henkelmann
Summary: The prevalence of nonspecific pyogenic spondylodiskitis has increased, causing high morbidity and mortality. The diagnosis is often delayed due to nonspecific clinical manifestations at the early stage. CT can assess the bony condition, while MRI is still the gold standard for diagnosis.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liang Zhao, Yizhen Pang, Shanyu Chen, Jianhao Chen, Yimin Li, Yifeng Yu, Chunbin Huang, Long Sun, Hua Wu, Haojun Chen, Qin Lin
Summary: This study investigated the prognostic value of semiquantitative parameters derived from [(68) Ga] Ga-fibroblast activation protein inhibitor (FAPI) PET/CT in patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy. The results showed that GTV(FAPI) was an independent prognostic factor for both progression-free survival (PFS) and overall survival (OS). This suggests that [(68) Ga] Ga-FAPI PET/CT may aid in personalized patient management by guiding treatment modifications before therapy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Guo, Yuhang Chen, Xiaojiang He, Hao Fu, Jingxiong Huang, Haojun Chen
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Liang Zhao, Yizhen Pang, Long Sun, Qin Lin, Haojun Chen
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yizhen Pang, Peipei Wang, Weizhi Xu, Liang Zhao, Haojun Chen
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yizhen Pang, Liang Zhao, Jianyang Fang, Jianhao Chen, Lingxin Meng, Long Sun, Hua Wu, Zhide Guo, Qin Lin, Haojun Chen
Summary: This study reports the design, synthesis, and evaluation of a FAPI tetramer, which exhibits high FAP-binding affinity and specificity both in vitro and in vivo. The tetramer shows improved tumor uptake and prolonged retention, making it a promising radiopharmaceutical for theranostic applications.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Simin Lin, Haojun Chen
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Weizhi Xu, Jiayu Cai, Tinghua Meng, Yizhen Pang, Haojun Chen
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liang Zhao, Yizhen Pang, Long Sun, Qin Lin, Hua Wu, Haojun Chen
Summary: FAPI PET shows promising results in the diagnosis of pancreatic cancer, with higher radiotracer uptake and better sensitivity than FDG PET. It may have better performance in TNM staging compared to 18F-FDG PET. Further research is needed to investigate the role of FAPI PET in guiding clinical management and its potential use in therapeutic response evaluation and early prognostication in pancreatic cancer. Well-designed prospective trials and histopathological examinations are necessary to clarify the usefulness of FAPI PET imaging in this context.
Article
Radiology, Nuclear Medicine & Medical Imaging
Haojun Chen, Yizhen Pang, Junpeng Li, Fei Kang, Weizhi Xu, Tinghua Meng, Qihang Shang, Jun Zhao, Yihui Guan, Hua Wu, Fang Xie, Jing Wang, Long Sun
Summary: This study investigated the role of [Ga-68]Ga-FAPI PET imaging in the detection and staging of GSRCC, and compared it with [F-18]FDG PET. The results showed that [Ga-68]Ga-FAPI PET had higher SUVmax and TBR values and exhibited higher diagnostic accuracy and sensitivity than [F-18]FDG PET in detecting primary and metastatic tumors.
EUROPEAN RADIOLOGY
(2023)
