Article
Rehabilitation
Linda Fordal, Jonas Stenberg, Grant L. Iverson, Simen B. Saksvik, Migle Karaliute, Anne Vik, Alexander Olsen, Toril Skandsen
Summary: This study aimed to examine the trajectories of persistent postconcussion symptoms (PPCS) after mild traumatic brain injury (MTBI) and investigate the factors associated with symptom reporting. The results showed a similar prevalence of moderate to severe PPCS in the MTBI group at 3 and 12 months post-injury. Individual trajectory analysis revealed considerable change in both symptom severity and total scores over time in the MTBI group. In addition, the presence of intracranial lesions was associated with a higher likelihood of improvement. Female gender and personal factors such as reduced employment, pain, poor sleep, low resilience, high neuroticism and pessimism, and a psychiatric history were associated with persistent symptoms. In conclusion, personal factors play an important role in the presence of persistent symptoms during the first year after MTBI.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Clinical Neurology
Jia-Wei Chung, Doresses Liu, Li Wei, Ya-Ting Wen, Hsin-Ying Lin, Huan-Chieh Chen, Hsiao-Yean Chiu
Summary: This study investigated the frequency and risk factors of postconcussion symptoms (PCSs) in older adults with mild traumatic brain injury (TBI), and examined their effects on quality of life. The results showed that PCSs were prevalent in older adults even in the chronic phase after a TBI, and significantly affected their quality of life.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Review
Clinical Neurology
Martijn de Neeling, Dirk Liessens, Bart Depreitere
Summary: Mild traumatic brain injury (mTBI) has a high incidence worldwide, and long-term persistent postconcussion symptoms (PPCS) are predicted by psychological and psychiatric factors. Anxiety, depressive symptoms, and emotional distress early after injury can predict PPCS burden and functional outcome. Coping styles, preinjury psychiatric disorders and mental health also correlate with PPCS burden and functional outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Behavioral Sciences
Rael T. Lange, Victoria C. Merritt, Tracey A. Brickell, Clifton L. Dalgard, Anthony R. Soltis, Jamie Hershaw, Sara M. Lippa, Jessica Gill, Louis M. French
Summary: Previous research has shown a relationship between the APOE e4 allele and worse neurobehavioral functioning following MTBI. In the MTBI group, participants with the APOE e4 allele had significantly worse scores on various measures, and consistently had a higher number of elevated measures compared to other subgroups. The APOE e4 allele could potentially be used in screening tools to predict SMVs at risk for poor long-term neurobehavioral outcomes and provide early intervention.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Clinical Neurology
Paul G. Harch
Summary: This systematic review examines the evidence for hyperbaric oxygen therapy in Persistent Postconcussion Syndrome using a dose-analysis based on the scientific definition of hyperbaric oxygen therapy. The results suggest that hyperbaric oxygen therapy at 1.5 ATA can significantly improve symptoms and cognitive function in patients with mild traumatic brain injury Persistent Postconcussion Syndrome, with positive and negative results found at different doses of oxygen and pressure.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Eva Keatley, Kathleen Bechtold, Kevin Psoter, Matthew E. Peters, Allen Everett, Vani Rao, Timothy E. Van Meter, Hayley Falk, Frederick K. Korley, Durga Roy
Summary: This study utilized group-based trajectory modeling (GBTM) to identify distinct patterns of symptom recovery following mild traumatic brain injury (TBI) in the first 6 months after injury. The findings identified four distinct trajectories of recovery, which can be helpful for understanding the natural history of recovery and developing targeted interventions.
Article
Clinical Neurology
Daan P. J. Verberne, Rudolf W. H. M. Ponds, Marielle E. A. L. Kroese, Melloney L. M. Wijenberg, Dennis G. Barten, Raphael Pasmans, Julie Staals, Caroline M. van Heugten
Summary: Research found that long-term psychosocial outcomes following mild traumatic brain injury (mTBI) and minor stroke are largely similar. Both groups showed improvements in anxiety, depression, cognitive problems and quality of life measures over the first year after injury, indicating that uniform aftercare for these conditions may be appropriate.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Sara M. Lippa, Rael T. Lange, Clifton L. Dalgard, Anthony R. Soltis, Vivian A. Guedes, Tracey A. Brickell, Louis M. French, Jessica Gill
Summary: This study demonstrates for the first time that APOE genotype is related to serum tau levels following mild traumatic brain injury (mTBI), with APOE e4 carriers having higher levels and APOE e2 carriers having lower levels, suggesting a possible protective effect.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Kaisa Maki, Taina Nybo, Marja Hietanen, Antti Huovinen, Ivan Marinkovic, Harri Isokuortti, Susanna Melkas
Summary: Perceived injustice is associated with self-reported symptoms in patients with mild traumatic brain injury (mTBI). Our results suggest that perceived injustice could be a relevant construct to consider in clinical management of patients with mTBI, and it could be a potential target for psychological interventions promoting recovery after mTBI.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Multidisciplinary Sciences
Mohammed M. Alnawmasi, Sieu K. Khuu
Summary: This study investigated the impact of TBI on the allocation and maintenance of visual attention to multiple moving targets using a multiple object tracking task. The results showed that patients with mild TBI had greater deficits in maintaining visual attention and detecting targets, particularly when the tracking load and distraction increased.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Ashley L. Ware, Catherine Lebel, Adrian Onicas, Nishard Abdeen, Miriam H. Beauchamp, Christian Beaulieu, Bruce H. Bjornson, William Craig, Mathieu Dehaes, Quynh Doan, Sylvain Deschenes, Stephen B. Freedman, Bradley G. Goodyear, Jocelyn Gravel, Andree-Anne Ledoux, Roger Zemek, Keith Owen Yeates
Summary: This prospective cohort study investigated the trajectories of brain gray matter macrostructure after pediatric mild traumatic brain injury (mTBI). The study found that mTBI can alter the typical course of cortical gray matter thinning up to 6 months postinjury, even after symptoms typically abate in most children. Therefore, it is important to examine neurobiology in relation to clinical outcomes and within a neurodevelopmental framework.
Article
Clinical Neurology
Karen Sullivan, Anna Keyter, Kelly Jones, Shanthi Ameratunga, Nicola Starkey, Suzanne Barker-Collo, James Webb, Alice Theadom
Summary: This study aimed to determine the percentage of people reporting atypical symptoms 1 month after mild traumatic brain injury (mTBI) and explore their links to recovery 12 months later. The results showed that atypical symptoms were not significant predictors of self-rated recovery at 12 months, while older age at injury and higher typical symptoms at 1 month were independently associated with poorer recovery at 12 months.
Article
Rehabilitation
Umesh M. Venkatesan, Deepa M. Ramanathan-Elion
Summary: This article discusses the theoretical foundations and conceptual framework of psychoeducation in cognitive rehabilitation interventions, and proposes the use of treatment theory and the Rehabilitation Treatment Specification System to personalize educational content and improve health literacy in Service Members and Veterans affected by mild traumatic brain injury.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Psychology, Clinical
Nicholas S. Guzowski, James B. Hoelzle, Michael A. McCrea, Lindsay D. Nelson
Summary: The study sheds light on the impact of somatic complaints in mTBI, showing that BSI-18 SOM and MMPI-2-RF RC1 are not interchangeable as they have only modest correlation and demonstrate differing associations with other clinical outcomes and mTBI.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Clinical Neurology
Alicia A. Swan, Eamonn Kennedy, Douglas B. Cooper, Megan E. Amuan, Jamie Mayo, David F. Tate, Kangwon Song, Blessen C. Eapen, Anne C. Van Cott, Maria R. Lopez, Mary Jo Pugh
Summary: The study examined the association between comorbidities (PTSD, depression, and/or headache) and polypharmacy with neurobehavioral symptoms among post-9/11 veterans with a history of mild traumatic brain injury (mTBI). The results showed that comorbidity burden and polypharmacy were associated with neurobehavioral symptom distress.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Lalon M. Kasuske, Peter Hoover, Tim Wu, Louis M. French, Jesus J. Caban
Summary: The study found that some ADSMs are diagnosed with BH conditions following a first mTBI, with 17% being new cases. ADSMs with a history of BH conditions show a significant increase in outpatient visits post-injury, and those newly diagnosed with BH conditions also exhibit higher outpatient utilization rates.
Article
Clinical Neurology
Thomas J. DeGraba, Kathy Williams, Robert Koffman, Jennifer L. Bell, Wendy Pettit, James P. Kelly, Travis A. Dittmer, George Nussbaum, Geoffrey Grammer, Joseph Bleiberg, Louis M. French, Treven C. Pickett
Summary: This study presents the outcomes of an interdisciplinary intensive outpatient program (IOP) for military service members with combat-related mTBI and comorbid PH conditions. The IOP achieved significant and sustainable symptom recovery in patients, with improvements seen across various outcome measures at discharge and follow-up visits. The findings support further research and consideration of this care model for complex medical conditions.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Rose K. Sia, Denise S. Ryan, Daniel Brooks, Janice M. Kagemann, Kraig S. Bower, Louis M. French, Grant A. Justin, Marcus H. Colyer
Summary: The study found that the visual and health-related quality of life among U.S. military service members with combat ocular trauma (COT) is generally good in the long term. However, those with both COT and a history of traumatic brain injury (TBI) showed significantly worse functioning in several domains compared to those without TBI.
Article
Psychology, Clinical
Tracey A. Brickell, Louis M. French, Jamie K. Sullivan, Nicole V. Varbedian, Megan M. Wright, Rael T. Lange
Summary: Close to half of spouse caregivers assisting service members and veterans following traumatic brain injury reported unhealthy family functioning, which was associated with worse caregiver health-related quality of life. However, healthy family functioning may mitigate poor HRQOL. Despite military policy limitations on family services, investing in caregiver and family-focused programs could improve outcomes for military families at a relatively modest cost.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2022)
Article
Neurosciences
Victoria C. Merritt, Tracey A. Brickell, Jason M. Bailie, Lars Hungerford, Sara M. Lippa, Louis M. French, Rael T. Lange
Summary: This study aimed to examine the relationship between resilience and self-reported neurobehavioral functioning following traumatic brain injury (TBI) in U.S. military service members and veterans (SMVs). The results showed that resilience and PTSD strongly influence neurobehavioral functioning among SMVs following TBI, regardless of injury group and time since injury.
Article
Health Care Sciences & Services
Rael T. Lange, Louis M. French, Jason M. Bailie, Victoria C. Merritt, Cassandra L. Pattinson, Lars D. Hungerford, Sara M. Lippa, Tracey A. Brickell
Summary: This study demonstrates the clinical utility of post-traumatic stress disorder (PTSD), low resilience, and poor sleep as risk factors for predicting neurobehavioral outcomes following traumatic brain injury (TBI). These risk factors, both individually and in combination, can be used for targeted early interventions in clinical practice.
QUALITY OF LIFE RESEARCH
(2022)
Article
Audiology & Speech-Language Pathology
Jennifer Rae Myers, Nancy Pearl Solomon, Rael T. Lange, Louis M. French, Sara M. Lippa, Tracey A. Brickell, Shelby Staines, Jenna Nelson, Doug S. Brungart, Carl A. Coelho
Summary: This exploratory study investigated discourse production in service members and veterans with mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD). The results revealed significant differences in global coherence and word count between different groups, while no significant differences were observed in other features. Structural features may serve as potential markers of cognitive communication deficits in individuals with mTBI.
AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2022)
Article
Psychology, Clinical
Tracey A. Brickell, Louis M. French, Nicole V. Varbedian, Jessie M. Sewell, Faith C. Schiefelbein, Megan M. Wright, Rael T. Lange
Summary: This study explored the relationship satisfaction and HRQOL among spouse caregivers of SMV with comorbid MTBI and PTSD, identifying factors such as anxiety, family disruption, and vigilance as strong predictors of relationship satisfaction. The Dissatisfied group consistently showed higher clinically elevated scores compared to the Satisfied group, highlighting the need for more integrated behavioral health treatment for family members in military TBI and PTSD care systems.
Article
Medicine, General & Internal
Remigio Flor, Boonkit Purt, Rose K. Sia, Denise S. Ryan, Janice M. Kagemann, Brittany E. Powell, Louis M. French, Hind Beydoun, Grant A. Justin, Marcus H. Colyer
Summary: This study is the first to evaluate the association between combat-related ocular injuries and traumatic brain injury (TBI). The results show that patients with combat-related ocular injuries are more likely to have a TBI, with closed globe injury being the only statistically significant predictive factor.
Article
Public, Environmental & Occupational Health
Tracey A. Brickell, Louis M. French, Megan M. Wright, Rael T. Lange
Summary: This study aimed to examine the relationship between SMV aggression and HRQOL in intimate partners of post-9/11 male SMVs. The results showed that caregivers of SMVs with moderate to severe aggression reported poor HRQOL, suggesting the importance of screening and treating aggression in SMVs and addressing the health needs of their caregivers.
WOMENS HEALTH ISSUES
(2022)
Article
Clinical Neurology
Sara M. Lippa, Rael T. Lange, Clifton L. Dalgard, Anthony R. Soltis, Vivian A. Guedes, Tracey A. Brickell, Louis M. French, Jessica Gill
Summary: This study demonstrates for the first time that APOE genotype is related to serum tau levels following mild traumatic brain injury (mTBI), with APOE e4 carriers having higher levels and APOE e2 carriers having lower levels, suggesting a possible protective effect.
FRONTIERS IN NEUROLOGY
(2022)
Article
Critical Care Medicine
Rael T. Lange, Sara Lippa, Tracey A. Brickell, Jessica Gill, Louis M. French
Summary: This study examines the association between serum tau, NFL, GFAP, and UCHL-1 concentrations and longitudinal changes in neurobehavioral functioning after military-related TBI. The study finds that elevated concentrations of these biomarkers are associated with the deterioration of neurobehavioral symptoms, suggesting their potential as prognostic tools for identifying individuals at risk of poor outcome after TBI.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Sara M. Lippa, Ping-Hong Yeh, John Ollinger, Tracey A. Brickell, Louis M. French, Rael T. Lange
Summary: The extant literature on the relationship between diffusion tensor imaging (DTI) and cognition following traumatic brain injury (TBI) is limited by small sample sizes and inappropriate control groups. This study examined DTI metric differences between different TBI groups and found a dose-response relationship between TBI severity and the strength of the relationship between white matter integrity and cognitive performance. Unlike previous findings, this study did not find any differences in DTI metrics between controls, mild TBI, and complicated TBI.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Audiology & Speech-Language Pathology
Daniel S. Talian, Megan M. Eitel, Danielle J. Zion, Stefanie E. Kuchinsky, Louis M. French, Tracey A. Brickell, Sara M. Lippa, Rael T. Lange, Douglas S. Brungart
Summary: This study describes normative ranges and interrater reliability of vestibular and balance function tests in a cohort of Service Members and Veterans. The results show excellent interrater reliability for most tests, providing important information for clinicians and scientists.
AMERICAN JOURNAL OF AUDIOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Alyssa Davidson, Megan Eitel, Rael T. Lange, Louis M. French, Sara Lippa, Tracey A. Brickell, Douglas Brungart
Summary: This article proposes an alternative technique for measuring Masking Level Difference (MLD) based on manual audiometry, which is just as reliable as the CD-based Wilson test. The study found that although the manual and Wilson MLD techniques produced significantly different thresholds, they can be transformed to obtain approximately equivalent scores. The manual MLD technique also showed stronger correlations with subjective and objective hearing measures compared to the Wilson technique.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2023)
