Journal
CELL CYCLE
Volume 15, Issue 12, Pages 1538-1544Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2015.1121334
Keywords
adult Drosophila midgut; bursicon-; rickets
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Funding
- NC3Rs
- Cancer Research UK [A11594]
- Sir Henry Dale Fellowship - Wellcome Trust
- Royal Society [104103/Z/14/Z]
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Bursicon is the main regulator of post molting and post eclosion processes during arthropod development. The active Bursicon hormone is a heterodimer of Burs- and Burs-. However, adult midguts express Burs- to regulate the intestinal stem cell niche. Here, we examined the potential expression and function of its heterodimeric partner, Burs- in the adult midgut. Unexpectedly, our evidence suggests that Burs- is not significantly expressed in the adult midgut. burs- mutants displayed the characteristic developmental defects but showed wild type-like adult midguts, thus uncoupling the developmental and adult phenotypes seen in burs- mutants. Gain of function data and ex vivo experiments using a cAMP biosensor, demonstrated that Burs- is sufficient to drive stem cell quiescence and to activate dLGR2 in the adult midgut.Our evidence suggests that the post developmental transactivation of dLGR2 in the adult midgut is mediated by Burs- and that the subunit of Bursicon is dispensable for these activities.
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