A Three-Part, Randomised Study to Investigate the Safety, Tolerability, Pharmacokinetics and Mode of Action of BC 007, Neutraliser of Pathogenic Autoantibodies Against G-Protein Coupled Receptors in Healthy, Young and Elderly Subjects

The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman  Pinschers of efficacy and outcomes

(2020) Sabine Werner et al.   ESC Heart Failure

In-Vivo Degradation of DNA-Based Therapeutic BC 007 in Humans

(2019) Hanna Davideit et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Xenoreactive antibodies and latent fibrin formation in VAD and cardiac transplant recipients can confound the detection and measurement of anti-AT1R antibodies

(2018) Martin Oaks et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Antigen-free control wells in an ELISA set-up for the determination of autoantibodies against G protein-coupled receptors—a requisite for correct data evaluation

(2018) Annekathrin Haberland et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

THE DNA-BASED THERAPEUTIC AGENT BC 007 COMPLETELY NEUTRALIZES AGONISTIC AUTOANTIBODIES DIRECTED AGAINST β1-ADRENOCEPTORS: RESULTS OF A PHASE 1 TRIAL

(2018) Johannes Mueller et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Functional autoantibodies in patients with different forms of dementia

(2018) Gerd Wallukat et al.   PLoS One

Aptamer BC007 for neutralization of pathogenic autoantibodies directed against G-protein coupled receptors: A vision of future treatment of patients with cardiomyopathies and positivity for those autoantibodies

(2016) Gerd Wallukat et al.   ATHEROSCLEROSIS

Aptamer BC 007 – A broad spectrum neutralizer of pathogenic autoantibodies against G-protein-coupled receptors

(2016) Annekathrin Haberland et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacokinetics and Safety of Single Intravenous Doses of JNJ-54452840, an Anti-β1-Adrenergic Receptor Antibody Cyclopeptide, in Healthy Male Japanese and Caucasian Participants

(2015) Ivo P. Nnane et al.   CLINICAL PHARMACOKINETICS

Diagnostic and therapeutic aspects of β1-adrenergic receptor autoantibodies in human heart disease

(2014) Beatrice Bornholz et al.   AUTOIMMUNITY REVIEWS

Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases

(2014) Gerd Wallukat et al.   Seminars in Immunopathology

Dilated cardiomyopathy: the complexity of a diverse genetic architecture

(2013) Ray E. Hershberger et al.   Nature Reviews Cardiology

Long-term benefits of immunoadsorption in β1-adrenoceptor autoantibody-positive transplant candidates with dilated cardiomyopathy

(2012) Michael Dandel et al.   EUROPEAN JOURNAL OF HEART FAILURE

Aliskiren, ALTITUDE, and the implications for ATMOSPHERE

(2012) John J.V. McMurray et al.   EUROPEAN JOURNAL OF HEART FAILURE

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

(2009) Sharon Ann Hunt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY