Feedback activation of neurofibromin terminates growth factor-induced Ras activation

The genomic landscape of juvenile myelomonocytic leukemia

(2015) Elliot Stieglitz et al.   NATURE GENETICS

A Meta-analysis of Somatic Mutations from Next Generation Sequencing of 241 Melanomas: A Road Map for the Study of Genes with Potential Clinical Relevance

(2014) J. Xia et al.   MOLECULAR CANCER THERAPEUTICS

Next-generation sequencing identifies rare variants associated with Noonan syndrome

(2014) P.-C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RSK2-induced stress tolerance enhances cell survival signals mediated by inhibition of GSK3β activity

(2013) Cheol-Jung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identifying the Ubiquitin Ligase Complex That Regulates the NF1 Tumor Suppressor and Ras

(2013) P. E. Hollstein et al.   Cancer Discovery

RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

(2012) Madhurima Saha et al.   BIOCHEMICAL JOURNAL

A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1

(2012) I. B. Stowe et al.   GENES & DEVELOPMENT

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

(2012) Y Romeo et al.   ONCOGENE

SAG/RBX2/ROC2 E3 Ubiquitin Ligase Is Essential for Vascular and Neural Development by Targeting NF1 for Degradation

(2011) Mingjia Tan et al.   DEVELOPMENTAL CELL

Altered ERK/MAPK signaling in the hippocampus of the mrsk2_KO mouse model of Coffin-Lowry syndrome

(2011) Anne Schneider et al.   JOURNAL OF NEUROCHEMISTRY

Deep proteome and transcriptome mapping of a human cancer cell line

(2011) N. Nagaraj et al.   Molecular Systems Biology

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

(2010) Matthias Drosten et al.   EMBO JOURNAL

Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (ERK) Signaling Network

(2010) Murat Cirit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Decisive Phosphorylation Sites for the Negative Feedback Regulation of SOS1 via ERK

(2010) Yuji Kamioka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TCR-Induced Activation of Ras Proceeds at the Plasma Membrane and Requires Palmitoylation of N-Ras

(2010) I. Rubio et al.   JOURNAL OF IMMUNOLOGY

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

(2010) Junxia Min et al.   NATURE MEDICINE

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway

(2009) Katharina Uhlenbrock et al.   FEBS LETTERS

Regulation of the Ras-GTPase activating protein neurofibromin by C-tail phosphorylation: implications for protein kinase C/Ras/extracellular signal-regulated kinase 1/2 pathway signaling and neuronal differentiation

(2009) George Leondaritis et al.   JOURNAL OF NEUROCHEMISTRY

Cell fate decisions are specified by the dynamic ERK interactome

(2009) Alex von Kriegsheim et al.   NATURE CELL BIOLOGY

The structure of the 5′-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation

(2008) Luchezar Karagyozov et al.   NUCLEIC ACIDS RESEARCH