Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

(2018) Fan Yao et al.   Nature Communications

The role of K63-linked polyubiquitination in cardiac hypertrophy

(2018) Kaowen Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lysine 63 ubiquitination is involved in the progression of tubular damage in diabetic nephropathy

(2017) Paola Pontrelli et al.   FASEB JOURNAL

Proteostasis in cardiac health and disease

(2017) Robert H. Henning et al.   Nature Reviews Cardiology

Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer

(2017) Na Xu et al.   Journal of the American Heart Association

UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised HeartsNovelty and Significance

(2016) Manish K. Gupta et al.   CIRCULATION RESEARCH

The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-createdMDM2T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells

(2016) Yajian Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

(2016) Paolo Arosio et al.   Nature Communications

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Protein Quality Control and Metabolism: Bidirectional Control in the Heart

(2015) Zhao V. Wang et al.   Cell Metabolism

COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac ProteotoxicityNovelty and Significance

(2015) Huabo Su et al.   CIRCULATION RESEARCH

Neuronal Aggregates: Formation, Clearance, and Spreading

(2015) Junghyun Lim et al.   DEVELOPMENTAL CELL

Emerging roles of Lys63-linked polyubiquitylation in immune responses

(2015) Xuefeng Wu et al.   IMMUNOLOGICAL REVIEWS

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

(2015) Mark J. Ranek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9

(2015) Kelli J. Carroll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The demographics of the ubiquitin system

(2015) Michael J. Clague et al.   TRENDS IN CELL BIOLOGY

Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy

(2015) David G. Ousterout et al.   Nature Communications

Sumo E2 Enzyme UBC9 Is Required for Efficient Protein Quality Control in Cardiomyocytes

(2014) Manish K. Gupta et al.   CIRCULATION RESEARCH

Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin

(2014) Peng Yin et al.   HUMAN MOLECULAR GENETICS

KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy

(2014) Ankit Garg et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteotoxicity: An underappreciated pathology in cardiac disease

(2014) Marco Sandri et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A

(2014) K. P. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

(2014) J Cheng et al.   Cell Death & Disease

Extracellular Chaperones and Proteostasis

(2013) Amy R. Wyatt et al.   Annual Review of Biochemistry

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Protein Kinase G Positively Regulates Proteasome-Mediated Degradation of Misfolded Proteins

(2013) Mark J. Ranek et al.   CIRCULATION

Posttranslational Modification and Quality Control

(2013) Xuejun Wang et al.   CIRCULATION RESEARCH

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

(2013) James A Nathan et al.   EMBO JOURNAL

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?

(2013) Monte S. Willis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A

(2012) M. Pulvino et al.   BLOOD

Desmin-related cardiomyopathy: an unfolding story

(2011) Patrick M. McLendon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy and p62 in Cardiac Proteinopathy

(2011) Qingwen Zheng et al.   CIRCULATION RESEARCH

Atg7 Induces Basal Autophagy and Rescues Autophagic Deficiency in CryAB R120G Cardiomyocytes

(2011) J. Scott Pattison et al.   CIRCULATION RESEARCH

Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy

(2010) Davide Gianni et al.   CIRCULATION

Doxycycline Attenuates Protein Aggregation in Cardiomyocytes and Improves Survival of a Mouse Model of Cardiac Proteinopathy

(2010) Hanqiao Zheng et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective

(2009) H. Su et al.   CARDIOVASCULAR RESEARCH

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins

(2009) Sjoerd J. L. van Wijk et al.   FASEB JOURNAL

Cardiomyocyte Expression of a Polyglutamine Preamyloid Oligomer Causes Heart Failure

(2008) J. Scott Pattison et al.   CIRCULATION