Journal
CELL AND TISSUE RESEARCH
Volume 367, Issue 1, Pages 141-154Publisher
SPRINGER
DOI: 10.1007/s00441-016-2475-x
Keywords
Mitochondria; Intravacuolar bacterial pathogens; Protein trafficking; Bacterial effector proteins; Mitochondrial function
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Manipulation of host cell function by bacterial pathogens is paramount for successful invasion and creation of a niche conducive to bacterial replication. Mitochondria play a role in many important cellular processes including energy production, cellular calcium homeostasis, lipid metabolism, haeme biosynthesis, immune signalling and apoptosis. The sophisticated integration of host cell processes by the mitochondrion have seen it emerge as a key target during bacterial infection of human host cells. This review highlights the targeting and interaction of this dynamic organelle by intravacuolar bacterial pathogens and the way that the modulation of mitochondrial function might contribute to pathogenesis.
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