COVID-19, Angiotensin Receptor Blockers, and the Brain

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

(2020) David Gurwitz   DRUG DEVELOPMENT RESEARCH

The neuroinvasive potential of SARS‐CoV2 may be at least partially responsible for the respiratory failure of COVID‐19 patients

(2020) Yan‐Chao Li et al.   JOURNAL OF MEDICAL VIROLOGY

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

(2020) Abdul Mannan Baig et al.   ACS Chemical Neuroscience

COVID-19, ACE2, and the cardiovascular consequences

(2020) Andrew M. South et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(2020) Furong Qi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Downregulation of spinal angiotensin converting enzyme 2 is involved in neuropathic pain associated with type 2 diabetes mellitus in mice

(2020) Ryota Yamagata et al.   BIOCHEMICAL PHARMACOLOGY

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China

(2020) Bo Li et al.   Clinical Research in Cardiology

Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?

(2020) Daniel Batlle et al.   CLINICAL SCIENCE

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

(2020) Jerome R. Lechien et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

COVID-19 and stroke—A global World Stroke Organization perspective

(2020) Hugh S Markus et al.   International Journal of Stroke

COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers

(2020) Ankit B. Patel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hypothesis: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19

(2020) James H Diaz   JOURNAL OF TRAVEL MEDICINE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

(2020) Muthiah Vaduganathan et al.   NEW ENGLAND JOURNAL OF MEDICINE

COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features

(2020) Neo Poyiadji et al.   RADIOLOGY

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease

(2020) Majd AlGhatrif et al.   JAMA Cardiology

Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China

(2020) Juyi Li et al.   JAMA Cardiology

Angiotensin receptor blockers and COVID-19

(2020) Juan M. Saavedra   PHARMACOLOGICAL RESEARCH

Revisiting the Brain Renin-Angiotensin System—Focus on Novel Therapies

(2019) Liwei Ren et al.   CURRENT HYPERTENSION REPORTS

Renin–angiotensin system research: from molecules to the whole body

(2019) Eriko Takimoto-Ohnishi et al.   Journal of Physiological Sciences

Olfactory Dysfunction in Neurodegenerative Diseases

(2018) Concepció Marin et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

(2018) Ben Readhead et al.   NEURON

Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death

(2018) Ana I. Rodriguez-Perez et al.   Neurotherapeutics

Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the risk of pneumonia and severe exacerbations in patients with COPD

(2018) Chih-Cheng Lai et al.   International Journal of Chronic Obstructive Pulmonary Disease

Telmisartan Protects a Microglia Cell Line from LPS Injury Beyond AT1 Receptor Blockade or PPARγ Activation

(2018) Abdel G. Elkahloun et al.   MOLECULAR NEUROBIOLOGY

The role of the blood-brain barrier in hypertension

(2017) Anthony Setiadi et al.   EXPERIMENTAL PHYSIOLOGY

Beneficial effects of Angiotensin II receptor blockers in brain disorders

(2017) J.M. Saavedra   PHARMACOLOGICAL RESEARCH

Renin-Angiotensin System in Diabetes

(2017) Johannes Rein et al.   PROTEIN AND PEPTIDE LETTERS

ACE2 Antagonizes VEGFa to Reduce Vascular Permeability During Acute Lung Injury

(2016) Xiaobo Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease

(2016) Hongpeng Jia   SHOCK

A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems

(2016) Jiaxi Xu et al.   Frontiers in Physiology

The association of renin–angiotensin system blockades and pneumonia requiring admission in patients with COPD

(2016) Junghyun Kim et al.   International Journal of Chronic Obstructive Pulmonary Disease

Comparing individual angiotensin-converting enzyme inhibitors with losartan in the risk of hospitalization for pneumonia and related mortality

(2015) Chia-Hsuin Chang et al.   JOURNAL OF HYPERTENSION

Neuroprotective Effects of Angiotensin Receptor Blockers

(2014) Sonia Villapol et al.   AMERICAN JOURNAL OF HYPERTENSION

Angiotensin receptor 1 blockade reduces secretion of inflammation associated cytokines from cultured human carotid atheroma and vascular cells in association with reduced extracellular signal regulated kinase expression and activation

(2014) Paula Clancy et al.   ATHEROSCLEROSIS

Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Entry That Act by Three Distinct Mechanisms

(2013) A. O. Adedeji et al.   JOURNAL OF VIROLOGY

Population-Based Study of Statins, Angiotensin II Receptor Blockers, and Angiotensin-Converting Enzyme Inhibitors on Pneumonia-Related Outcomes

(2012) E. M. Mortensen et al.   CLINICAL INFECTIOUS DISEASES

Aging and the Renin-Angiotensin System

(2012) Sara Conti et al.   HYPERTENSION

Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry

(2012) M. Kawase et al.   JOURNAL OF VIROLOGY

Impact of ACE2 Deficiency and Oxidative Stress on Cerebrovascular Function With Aging

(2012) Ricardo A. Peña Silva et al.   STROKE

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Upregulation of the Chemokine (C-C Motif) Ligand 2 via a Severe Acute Respiratory Syndrome Coronavirus Spike-ACE2 Signaling Pathway

(2010) I.-Y. Chen et al.   JOURNAL OF VIROLOGY

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

(2009) Hong Peng Jia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2

(2009) Jan Wysocki et al.   HYPERTENSION

Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro

(2009) Yiu-Wing Kam et al.   PLoS One

Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2

(2008) J. Netland et al.   JOURNAL OF VIROLOGY