Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 77, Issue 22, Pages 4601-4614Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-020-03554-3
Keywords
Skin cancer; Basal cell carcinoma; Cutaneous squamous cell carcinoma; Epidermis; Wound repair; Ultraviolet radiation
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Funding
- University of Turku (UTU)
- Finnish Cancer Research Foundation
- Cancer Society of South-West Finland
- Jane and Aatos Erkko Foundation
- Sigrid Juselius Foundation
- Turku University Hospital [13336]
- Kymenlaakso Regional Fund of the Finnish Cultural Foundation
- Ida Montin Foundation
- Instrumentarium Science Foundation
- Paulo Foundation
- Maud Kuistila Memorial Foundation
- University of Turku
- Turku University Foundation
- Turku University Central Hospital
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Long non-coding RNAs (lncRNAs) are a largely uncharacterized group of non-coding RNAs with diverse regulatory roles in various biological processes. Recent observations have elucidated the functional roles of lncRNAs in cutaneous biology,e.g.in proliferation and differentiation of epidermal keratinocytes and in cutaneous wound repair. Furthermore, the role of lncRNAs in keratinocyte-derived skin cancers is emerging, especially in cutaneous squamous cell carcinoma (cSCC), which presents a significant burden to health care services worldwide and causes high mortality as metastatic disease. Elucidation of the functions of keratinocyte-specific lncRNAs will improve understanding of the molecular pathogenesis of epidermal disorders and skin cancers and can be exploited in development of new diagnostic and therapeutic applications for keratinocyte carcinomas. In this review, we summarize the current evidence of functionally important lncRNAs in cutaneous biology and in keratinocyte carcinomas.
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