Journal
CELL METABOLISM
Volume 31, Issue 4, Pages 660-662Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2020.03.012
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Funding
- Landry Cancer Research Fellowship
- Charles H. Hood Foundation
- Pathology Department at Boston Children's Hospital
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In this issue of Cell Metabolism, Yang et al., 2020 report that serine is a source of mitochondrial NADH derived from one-carbon metabolism. Serine becomes a major source of NADH when cellular respiration is inhibited, and the un-utilized, accumulated NADH inhibits the TCA cycle and slows proliferation.
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