Article
Medicine, Research & Experimental
Zhihui Gao, Qianqing Wang, Mei Ji, Xiangcui Guo, Li Li, Xiaoke Su
Summary: The study revealed that UCA1 regulates SOX2 expression by sponging miR-122-5p, affecting the functions of CC stem cells, while CaSki-Exo promotes the invasion and migration of CC stem cells. Silencing UCA1 or up-regulating miR-122-5p reduced the invasion and migration abilities of CC stem cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Ye Feng, Ying Xu, Yongjian Gao, Yiying Chen, Xuefeng Wang, Zhi Chen
Summary: SOX2OT is an up-regulated oncogene in CRC, promoting cell proliferation, migration, and invasion. It acts as a competing endogenous RNA to upregulate SOX5 by sponging miR-194-5p, thus affecting tumorgenesis of CRC.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Fiona J. Ruiz, Matthew Inkman, Ramachandran Rashmi, Naoshad Muhammad, Nishanth Gabriel, Christopher A. Miller, Michael D. McLellan, Michael Goldstein, Stephanie Markovina, Perry W. Grigsby, Jin Zhang, Julie K. Schwarz
Summary: Persistent HPV infection is the main cause of cervical cancer, and patients with cervical tumors containing HPV genotypes other than HPV 16 have worse survival outcomes after CRT. High levels of E6*I and E6 expression may represent novel biomarkers of CRT efficacy.
Article
Cell Biology
Shimiao Huang, Xuan Wang, Yin Zhu, Yadong Wang, Jiaxuan Chen, Haoxuan Zheng
Summary: This study elucidates the mechanism by which SOX2 promotes VM formation in colorectal cancer. SOX2 overexpression enhances glycolysis and sustains VM formation through the transcriptional activation of lncRNA AC005392.2. Overexpression of AC005392.2 increases the stability of GLUT1 protein, leading to enhanced glycolysis and VM mediated by SOX2. Clinical analysis reveals a positive correlation between the expression levels of AC005392.2, GLUT1, and EPHA2 with SOX2, as well as poor prognoses in patients with CRC.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Hongliang Dong, Lili Zeng, Weiwei Chen, Qian Zhang, Fei Wang, Yan Wu, Bingjie Cui, Jingjing Qi, Xin Zhang, Cuilan Liu, Jiong Deng, Yong Yu, Clemens A. Schmitt, Jing Du
Summary: Despite advances in precision medicine and immunotherapy, lung cancer mortality remains high. The SHH cascade and GLI1 play a critical role in the stemness and drug resistance of lung cancer. Non-canonical aberrant upregulation of GLI1 through the GLI1-SOX2OT loop, mediated by the METTL3/14/IGF2BP2 pathway, promotes the proliferation of lung cancer cells. Inhibition of this loop shows promise as a potential therapeutic target for lung cancer treatment.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Yi-Hung Sun, Ying-Hsiang Chou, Hsueh-Yu Tsai, Yi-Hsuan Hsiao, Chung-Yuan Lee, Shun-Fa Yang, Ke-Hsin Ting, Po-Hui Wang
Summary: This study investigated the association between genetic variants of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALATI) and cervical cancer (CC) in Taiwanese women. The results showed that lncRNA MALATI genetic variants were not related to the occurrence and clinicopathological characteristics of CC, as well as the 5-year survival of patients. However, pelvic lymph node metastasis was identified as an independent predictor of 5-year survival in CC.
Article
Medicine, General & Internal
Zhichao Zhang, Jun Wang, Jinming Wei, Chuxiong Li
Summary: SOX2OT shows significant clinical value in predicting the development, progression, and prognosis of colon cancer, with high levels indicating an increased risk of unfavorable outcomes.
ACTA MEDICA MEDITERRANEA
(2021)
Review
Biochemistry & Molecular Biology
Hober Nelson Nunez-Martinez, Felix Recillas-Targa
Summary: Thousands of long noncoding RNAs (lncRNAs) in mammalian genomes play important regulatory functions, and their functional mechanisms can be achieved through RNA-based or RNA-independent ways, further expanding the understanding of their significance in genome biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Christer Borgfeldt, Anna Soderlund-Strand, Lotten Darlin Flygh, Ola Forslund
Summary: The study found a prevalence rate of 2.9% for HPV73 in cervical cancers, with a high occurrence of 55.5% in Aptima HPV-negative cancers, suggesting that detection of HPV73 should be included in future primary HPV screening programs.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Ke Chen, Bo Yu, Jie Liao
Summary: This study showed that lncRNA SOX2OT alleviates the pathogenesis of DN by regulating Akt/mTOR-mediated autophagy, suppressing the proliferation and fibrosis of mesangial cells.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lindsay M. Payer, Jared P. Steranka, Maria S. Kryatova, Giacomo Grillo, Mathieu Lupien, Pedro P. Rocha, Kathleen H. Burns
Summary: Alu elements are high-copy interspersed repeats that have accumulated near genes during primate and human evolution, contributing to structural variation in modern humans. This study investigates the regulatory effects of polymorphic Alu insertions on gene expression, particularly in relation to disease risk. The findings demonstrate that Alu genotype can alter expression of genes involved in cancer risk, highlighting the potential contribution of commonly occurring polymorphic Alu elements to disease risk.
Article
Genetics & Heredity
Youssef Fouani, Akram Gholipour, Maziar Oveisee, Alireza Shahryari, Hooshang Saberi, Seyed Javad Mowla, Mahshid Malakootian
Summary: Numerous recent investigations have focused on the dysregulated expression of long-noncoding RNAs (lncRNAs) in various cancer types, pointing to their significant involvement in tumourigenesis. This study examined the expression patterns of SOX2OT variants and SOX2 in three types of brain tumors and four brain tumor cell lines, revealing distinct expression patterns and suggesting their potential roles in brain tumourigenesis. The findings also highlight the potential usefulness of SOX2OT-S1, SOX2OT-S2, and SOX2 in molecular diagnosis and brain tumour classification.
JOURNAL OF GENETICS
(2023)
Article
Oncology
Yanping Gao, Nannan Zhang, Zihang Zeng, Qiuji Wu, Xueping Jiang, Shuying Li, Wenjie Sun, Jianguo Zhang, Yangyi Li, Jiali Li, Fajian He, Zhengrong Huang, Jinfang Zhang, Yan Gong, Conghua Xie
Summary: PCAT1 inhibits immune cell infiltration and promotes tumorigenesis and immunosuppression in NSCLC. Knockdown of PCAT1 restrains proliferation, increases apoptosis and inhibits cell metastasis. PCAT1 activates SOX2, which further accelerates tumorigenesis and immune suppression.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Developmental Biology
Ivelisse Cajigas, Abhijit Chakraborty, Madison Lynam, Kelsey R. Swyter, Monique Bastidas, Linden Collens, Hao Luo, Ferhat Ay, Jhumku D. Kohtz
Summary: The study reveals that Evf2 interacts with factors like Sox2 to regulate gene expression on chromosome 6 in mice. The interactions between Evf2 and Sox2 influence the activity of Dlx5/6UCE, ultimately affecting gene expression.
Article
Toxicology
Ming Zhang, Yanmin Li, Fuwei Zhang, Hui Geng, Yimin Cai, Zequn Lu, Bin Li, Caibo Ning, Wenzhuo Wang, Haijie Li, Jianbo Tian, Ying Zhu, Xiaoping Miao
Summary: By integrating genome-wide lncRNA data with a cross-ancestry meta-analysis of PDAC GWASs, a comprehensive atlas of PDAC-associated lncRNAs was depicted. PDAC-associated lncRNAs could function by altering chromatin activity, transcription factors, and RNA-binding protein binding affinity. Importantly, genetic variants linked to PDAC preferentially occur at PDAC-associated lncRNA regions, supporting the biological and clinical relevance of PDAC-associated lncRNAs.
ARCHIVES OF TOXICOLOGY
(2023)