Article
Cardiac & Cardiovascular Systems
Dandan Yang, Xiaoping Wan, Adrienne T. Dennis, Emre Bektik, Zhihua Wang, Mauricio G. S. Costa, Charline Fagnen, Catherine Venien-Bryan, Xianyao Xu, Daniel H. Gratz, Thomas J. Hund, Peter J. Mohler, Kenneth R. Laurita, Isabelle Deschenes, Ji-Dong Fu
Summary: This study reveals a novel biophysical action of endogenous miRs in modulating cardiac electrophysiology through noncanonical mechanisms. Endogenous miR1 physically binds with cardiac membrane protein Kir2.1, suppressing I-K1 and affecting action potential of cardiomyocytes. The findings suggest that miRs may be involved in the pathogenesis of cardiac arrhythmias by regulating ion channel physiology and pathology.
Article
Cardiac & Cardiovascular Systems
Fiorenzo Gaita, Natascia Cerrato, Carla Giustetto, Annamaria Martino, Laura Bergamasco, Michele Millesimo, Lorella Barbonaglia, Paula Carvalho, Domenico Caponi, Andrea Saglietto, Giacomo Bonacchi, Francesca Bianchi, Elisa Silvetti, Cinzia Crescenzi, Stefano Canestrelli, Melissa De Maio, Gaetano Maria De Ferrari, Giuseppe Musumeci, Francesco Rametta, Marco Scaglione, Leonardo Calo
Summary: The study evaluated the long-term prognosis of a large cohort of asymptomatic patients with Brugada ECG pattern. The entire population of asymptomatic patients with BrECG exhibited a relatively low event rate per year, with those having spontaneous type-1 BrECG and positive EPS showing higher risk. Asymptomatic patients with drug-induced-only BrECG had minimal arrhythmic risk, but ongoing follow-up was recommended to detect the appearance of spontaneous type-1 BrECG pattern.
Article
Medicine, General & Internal
Gan-Xiao Chen, Hector Barajas-Martinez, Giuseppe Ciconte, Cheng- Wu, Michelle M. Monasky, Hao Xia, Bian Li, John A. Capra, Kai Guo, Zhong-He Zhang, Xiu Chen, Bo Yang, Hong Jiang, Gary Tse, Chloe Miu Mak, Yoshiyasu Aizawa, Michael H. Gollob, Charles Antzelevitch, Arthur A. M. Wilde, Carlo Pappone, Dan Hu
Summary: In this study, a clinical analysis was conducted on 261 patients diagnosed with fever-induced Brugada syndrome (BrS). It was found that patients carrying pathogenic or likely pathogenic (P/LP) SCN5A gene variants were more susceptible to fever-induced BrS at a younger age, especially among Caucasian individuals and females. These patients exhibited significant electrophysiological abnormalities and had a higher incidence of major cardiac events (MCE).
Article
Cardiac & Cardiovascular Systems
Ravi A. Shah, Babken Asatryan, Ghaith Sharaf Dabbagh, Nay Aung, Mohammed Y. Khanji, Luis R. Lopes, Stefan van Duijvenboden, Anthony Holmes, Daniele Muser, Andrew P. Landstrom, Aaron Mark Lee, Pankaj Arora, Christopher Semsarian, Virend K. Somers, Anjali T. Owens, Patricia B. Munroe, Steffen E. Petersen, C. Anwar A. Chahal
Summary: This study aimed to investigate the phenotype and penetrance of dilated cardiomyopathy (DCM) gene variants in the general population. Analysis of UK Biobank data revealed that approximately 1 in 6 adults with putative pathogenic variants in DCM genes exhibited early DCM features potentially associated with DCM genotype, with arrhythmias being the most common manifestation.
Article
Cardiac & Cardiovascular Systems
Giovanna Nasilli, Loukia Yiangou, Chiara Palandri, Elisabetta Cerbai, Richard P. Davis, Arie O. Verkerk, Simona Casini, Carol Ann Remme
Summary: SCN5A mutations are associated with various cardiac phenotypes. The study found that mexiletine can improve the mixed phenotype caused by the SCN5A-1795insD mutation. This study demonstrates for the first time the therapeutic benefit of mexiletine in a human cardiomyocyte model of SCN5A overlap syndrome.
Article
Biochemistry & Molecular Biology
Soroosh Solhjoo, Ting Liu, Agnieszka Sidor, Dong I. Lee, Brian O' Rourke, Charles Steenbergen
Summary: Ischemia and reperfusion affect multiple elements of cardiomyocyte electrophysiology, especially within the mitochondria. Here, through confocal microscopy, we investigate the mechanisms underlying the postischemic Delta Psi oscillations, focusing on the role of Ca2+ and oxidative stress. We found that transient bouts of increased mitochondrial oxidative stress underlie postischemic Delta Psi oscillations, regardless of Ca2+ dynamics.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Biology
Carol Ann Remme
Summary: The influx of sodium ions through voltage-gated sodium channels is crucial for proper electrical conduction in the heart. Dysfunction of sodium channels can lead to life-threatening arrhythmias in acquired conditions and inherited disorders. Recent research has revealed the complex nature of sodium channel distribution and function, as well as its impact on cardiac structural integrity. Moreover, sodium channels and their role in various extracardiac tissues are being increasingly recognized. This review provides an overview of these novel insights and their contribution to our understanding of sodium channelopathies and dysfunction.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ke Gong, Kai Yang, Ting Xie, Yong Luo, Hui Guo, Zhiping Tan, Jinlan Chen, Qin Wu, Yibo Gong, Luyao Wei, Jinwen Luo, Yao Yao, Yifeng Yang, Li Xie
Summary: By analyzing gene expression files in the GEO database, this study identified differentially expressed circRNAs, miRNAs, and mRNAs in HCM, and predicted the target molecules of circRNAs and miRNAs. A ceRNA network was constructed by calculating the intersection of these differentially expressed RNA molecules and their expected targets. Functional enrichment analysis revealed the potential etiology of HCM, which is associated with calcium channel release. The qPCR results showed differential expression levels of circRNA, miRNA, and mRNA, suggesting their potential as noninvasive indicators for early screening and prognostic prediction of HCM.
Review
Medicine, General & Internal
Mariana Brandao, Riccardo Bariani, Ilaria Rigato, Barbara Bauce
Summary: Desmoplakin (DSP) is a crucial protein for cell-to-cell adhesion in cardiomyocytes, and genetic variants in DSP have been associated with several types of myocardial diseases. Left-dominant arrhythmogenic cardiomyopathy is the most common phenotype in individuals with DSP variants. A new form of cardiomyopathy, known as Desmoplakin cardiomyopathy, has recently been identified, characterized by left ventricular involvement, extensive fibrosis, high arrhythmic risk, and acute myocardial injury episodes. This review aims to summarize the current evidence on DSP cardiomyopathy and identify gaps in knowledge for future research.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medical Laboratory Technology
Mireia Alcalde, Rocio Toro, Fernando Bonet, Jose Cordoba-Caballero, Estefania Martinez-Barrios, Juan Antonio Ranea, Marta Vallverdu-Prats, Ramon Brugada, Viviana Meraviglia, Milena Bellin, Georgia Sarquella-Brugada, Oscar Campuzano
Summary: Arrhythmogenic cardiomyopathy is a rare inherited disease characterized by fibro-fatty replacement of the myocardium, leading to malignant arrhythmias and a high risk of sudden cardiac death. Early identification of at-risk individuals is crucial to prevent lethal episodes. Genetic analysis can identify deleterious rare variants in genes encoding desmosome proteins, but other factors like microRNAs may also modulate disease onset and outcome. Understanding the role of microRNAs may have clinical implications as potential biomarkers in arrhythmogenic cardiomyopathy.
TRANSLATIONAL RESEARCH
(2023)
Review
Health Care Sciences & Services
Davide Lazzeroni, Antonio Crocamo, Valentina Ziveri, Maria Francesca Notarangelo, Davide Rizzello, Matteo Spoladori, Davide Donelli, Giovanna Cacciola, Diego Ardissino, Giampaolo Niccoli, Giovanni Peretto
Summary: The aim of this review is to provide a stepwise hierarchical approach for global sudden death risk estimation in primary cardiomyopathies. This personalized approach starts with clinical evaluation, followed by electrocardiographic monitoring and multimodality imaging, and concludes with genetic evaluation and electro-anatomical mapping. The assessment of sudden cardiac death risk in cardiomyopathies depends on a multiparametric approach.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Health Care Sciences & Services
Paloma Jorda, Rocio Toro, Carles Diez, Joel Salazar-Mendiguchia, Anna Fernandez-Falgueras, Alexandra Perez-Serra, Monica Coll, Marta Puigmule, Elena Arbelo, Ana Garcia-Alvarez, Georgia Sarquella-Brugada, Sergi Cesar, Coloma Tiron, Anna Iglesias, Josep Brugada, Ramon Brugada, Oscar Campuzano
Summary: Rare variants in the RBM20 gene are associated with malignant arrhythmias, early recognition of arrhythmic genotypes is crucial for avoiding lethal episodes, and personalized medicine may impact the adoption of preventive measures.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Artur Santos-Miranda, Alexandre D. Costa, Julliane Joviano-Santos, Paula Rhana, Alexandre Santos Bruno, Peter Rocha, Stefany Bruno Cau, Leda Q. Vieira, Jader S. Cruz, Danilo Roman-Campos
Summary: This study demonstrated the potential therapeutic value of targeting the Ca2+/CaM-CaMKII pathway in preventing and treating Chagasic cardiomyopathy. Inhibition of this pathway reversed arrhythmic profiles and restored cardiac function in experimental models, suggesting a promising strategy for managing this condition.
Review
Pediatrics
Georgia Sarquella-Brugada, Anna Fernandez-Falgueras, Sergi Cesar, Elena Arbelo, Paloma Jorda, Ana Garcia-Alvarez, Jose Carlos Cruzalegui, Erika Fernanda Merchan, Victoria Fiol, Josep Brugada, Ramon Brugada, Oscar Campuzano
Summary: The study aims to correlate phenotype with genotype in rare variants of Triadin leading to malignant arrhythmias in children, identifying 14 rare genetic alterations in the TRDN gene. These potentially pathogenic changes are located in a specific area of TRDN, emphasizing the significance of this hotspot as an arrhythmogenic gene region. Early recognition and comprehensive interpretation of Triadin alterations are crucial for preventive measures and avoidance of malignant arrhythmogenic events in pediatric patients.
FRONTIERS IN PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Julia Cadrin-Tourigny, Laurens P. Bosman, Anna Nozza, Weijia Wang, Rafik Tadros, Aditya Bhonsale, Mimount Bourfiss, Annik Fortier, Oyvind H. Lie, Ardan M. Saguner, Anneli Svensson, Antoine Andorin, Crystal Tichnell, Brittney Murray, Katja Zeppenfeld, Maarten P. van den Berg, Folkert W. Asselbergs, Arthur A. M. Wilde, Andrew D. Krahn, Mario Talajic, Lena Rivard, Stephen Chelko, Stefan L. Zimmerman, Ihab R. Kamel, Jane E. Crosson, Daniel P. Judge, Sing-Chien Yap, Jeroen F. van der Heijden, Harikrishna Tandri, Jan D. H. Jongbloed, Marie-Claude Guertin, J. Peter van Tintelen, Pyotr G. Platonov, Firat Duru, Kristina H. Haugaa, Paul Khairy, Richard N. W. Hauer, Hugh Calkins, Anneline S. J. M. te Riele, Cynthia A. James
Summary: We developed a prediction model for incident VA/SCD in ARVC patients using readily available clinical parameters, which accurately distinguished patients with and without events and showed superior clinical benefit compared to current ICD placement algorithms.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Helge Servatius, Thomas Kuffer, Samuel H. Baldinger, Babken Asatryan, Jens Seiler, Hildegard Tanner, Jan Novak, Anna Lam, Fabian Noti, Andreas Haeberlin, Antonio Madaffari, Romy Sweda, Aline Muhl, Mattia Branca, Sophie Dutschler, Gabor Erdoes, Frank Stuber, Lorenz Theiler, Tobias Reichlin, Laurent Roten
Summary: This study aimed to compare the efficacy of DEX and PRO in AF ablation procedures, and found that there was no significant difference in primary endpoints between the two groups. However, patients in the PRO group reported higher satisfaction with the procedural sedation.
Review
Cardiac & Cardiovascular Systems
Bhurint Siripanthong, Babken Asatryan, Thomas C. Hanff, Salman R. Chatha, Mohammed Y. Khanji, Fabrizio Ricci, Daniele Muser, Victor A. Ferrari, Saman Nazarian, Pasquale Santangeli, Rajat Deo, Leslie T. Cooper, Saidi A. Mohiddin, C. Anwar A. Chahal
Summary: The mechanisms of myocardial injury related to COVID-19 include direct viral invasion and indirect cellular injuries. Some patients experience long-term structural and functional changes in the heart, such as myocardial fibrosis, edema, intraventricular thrombi, and reduced cardiac function.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, General & Internal
Helge Servatius, Simon Raab, Babken Asatryan, Andreas Haeberlin, Mattia Branca, Stefano de Marchi, Nicolas Brugger, Nikolas Nozica, Eleni Goulouti, Elena Elchinova, Anna Lam, Jens Seiler, Fabian Noti, Antonio Madaffari, Hildegard Tanner, Samuel H. Baldinger, Tobias Reichlin, Matthias Wilhelm, Laurent Roten
Summary: Structural and electrical atrial remodeling is more advanced in patients with hypertrophic cardiomyopathy (HCM) compared to patients with hypertensive heart disease (HHD) and athletes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Ali J. Marian
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ravi A. Shah, Babken Asatryan, Ghaith Sharaf Dabbagh, Nay Aung, Mohammed Y. Khanji, Luis R. Lopes, Stefan van Duijvenboden, Anthony Holmes, Daniele Muser, Andrew P. Landstrom, Aaron Mark Lee, Pankaj Arora, Christopher Semsarian, Virend K. Somers, Anjali T. Owens, Patricia B. Munroe, Steffen E. Petersen, C. Anwar A. Chahal
Summary: This study aimed to investigate the phenotype and penetrance of dilated cardiomyopathy (DCM) gene variants in the general population. Analysis of UK Biobank data revealed that approximately 1 in 6 adults with putative pathogenic variants in DCM genes exhibited early DCM features potentially associated with DCM genotype, with arrhythmias being the most common manifestation.
Article
Cardiac & Cardiovascular Systems
Alessandro Spirito, Lukas Vaisnora, Athanasios Papadis, Fortunato Iacovelli, Celestino Sardu, Alexandra Selberg, Sarah Baer, Raminta Kavaliauskaite, Fabrice Temperli, Babken Asatryan, Thomas Pilgrim, Lukas Hunziker, Dik Heg, Marco Valgimigli, Stephan Windecker, Lorenz Raeber
Summary: This study assessed the frequency, predictors, and clinical impact of acute coronary occlusion in hemodynamically stable and unstable out-of-hospital cardiac arrest patients without ST-segment elevation. The results showed that acute coronary occlusions were found in both stable and unstable patients and were associated with a higher risk of cardiovascular death.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nikolas Nozica, Babken Asatryan, Stefania Aur, Judith Bouchardy Clement, Markus Schwerzmann, Fu Guan, Patrizio Pascale, Matthias Gass, Firat Duru, Tobias Reichlin, Etienne Pruvot, Thomas Wolber, Laurent Roten
Summary: This study indicates that arrhythmias are common in adult patients with dextro-transposition of the great arteries (D-TGA) and atrial switch surgery, and associated rhythm interventions are frequent. Approximately half of these patients experience arrhythmias, with 10% not surviving until the age of 35 without left ventricular assist device or heart transplantation, and the prognosis is worse in patients with concomitant ventricular septum defect.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Cardiac & Cardiovascular Systems
Antoine Deliniere, Christelle Haddad, Claudia Herrera-Siklody, Alexis Hermida, Etienne Pruvot, Sabrina Bressieux-Degueldre, Gilles Millat, Alexandre Janin, Jean-Sylvain Hermida, Babken Asatryan, Philippe Chevalier
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jens Maurhofer, Thomas Kueffer, Sven Knecht, Antonio Madaffari, Patrick Badertscher, Jens Seiler, Philipp Krisai, Corinne Jufer, Babken Asatryan, Dik Heg, Helge Servatius, Hildegard Tanner, Michael Kuhne, Laurent Roten, Christian Sticherling, Tobias Reichlin
Summary: This study aims to compare the efficacy and safety of the novel PolarX cryoballoon and the standard Arctic Front cryoballoon for first pulmonary vein isolation (PVI) in patients with symptomatic paroxysmal atrial fibrillation (AF). A total of 200 patients will be randomized and the procedure and follow-up outcomes will be assessed.
CONTEMPORARY CLINICAL TRIALS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Babken Asatryan, Rebecca McClellan, Caridad M. De La Uz
Review
Cardiac & Cardiovascular Systems
Babken Asatryan, Hidde Bleijendaal, Arthur A. M. Wilde
Summary: The use of artificial intelligence, particularly machine learning and deep learning, is increasingly important in healthcare, specifically in addressing challenges in inherited arrhythmia syndromes. AI can improve clinical diagnosis, risk stratification, and prediction of response to therapy, filling gaps in current approaches.
Editorial Material
Cardiac & Cardiovascular Systems
Babken Asatryan, Pieter G. Postema, Arthur A. M. Wilde
Editorial Material
Cardiac & Cardiovascular Systems
Babken Asatryan
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Luc Bourquin, Thomas Kuffer, Babken Asatryan, Patrick Badertscher, Samuel H. Baldinger, Sven Knecht, Jens Seiler, Florian Spies, Helge Servatius, Michael Kuhne, Fabian Noti, Stefan Osswald, Andreas Haeberlin, Hildegard Tanner, Laurent Roten, Tobias Reichlin, Christian Sticherling
Summary: The study aimed to validate a clinical score based on age, sex, and hypertension for predicting the origin of LVOT in patients with OTVA. The results showed that the clinical score had lower sensitivity and specificity, but combining it with an ECG algorithm improved the predictability of LVOT origin.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Meeting Abstract
Medicine, General & Internal
T. Kueffer, S. H. Baldinger, H. Servatius, A. Madaffari, J. Seiler, A. Muhl, F. Franzeck, G. Thalmann, B. Asatryan, A. Haeberlin, F. Noti, H. Tanner, L. Roten, T. Reichlin
SWISS MEDICAL WEEKLY
(2022)