Heritable arrhythmia syndromes associated with abnormal cardiac sodium channel function: ionic and non-ionic mechanisms

Rapid Na+ accumulation by a sustained action potential impairs mitochondria function and induces apoptosis in HEK293 cells expressing non-inactivating Na+ channels

(2019) Keisuke Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Distinct Pool of Nav1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes

(2019) Jean-Sébastien Rougier et al.   Frontiers in Physiology

Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice

(2019) Simona Casini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure of the Cardiac Sodium Channel

(2019) Daohua Jiang et al.   CELL

A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy

(2018) Mathilde R Rivaud et al.   EUROPEAN HEART JOURNAL

Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy

(2018) Mathilde R. Rivaud et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A common polymorphism in the SCN5A gene is associated with dilated cardiomyopathy

(2018) Cristina Mazzaccara et al.   Journal of Cardiovascular Medicine

KV4.3 Expression Modulates NaV1.5 Sodium Current

(2018) Vincent Portero et al.   Frontiers in Physiology

The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

(2018) Rengasayee Veeraraghavan et al.   eLife

Therapeutic approaches for Long QT syndrome type 3: an update

(2017) Arthur A M Wilde et al.   EUROPACE

Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes

(2017) Mathilde R. Rivaud et al.   Journal of the American Heart Association

Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc

(2016) Alejandra Leo-Macias et al.   Nature Communications

Further Insights in the Most CommonSCN5AMutation Causing Overlapping Phenotype of Long QT Syndrome, Brugada Syndrome, and Conduction Defect

(2016) Christian Veltmann et al.   Journal of the American Heart Association

How do voltage-gated sodium channels enhance migration and invasiveness in cancer cells?

(2015) Pierre Besson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In VivoCLINICAL PERSPECTIVE

(2015) Patric Glynn et al.   CIRCULATION

Role of Sodium and Calcium Dysregulation in Tachyarrhythmias in Sudden Cardiac Death

(2015) S. Wagner et al.   CIRCULATION RESEARCH

Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction

(2015) Gong Xin Liu et al.   HEART RHYTHM

Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications

(2015) Céline Marionneau et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis

(2015) Michaela Nelson et al.   Molecular Cancer

SCN5Avariant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia

(2015) Hassan Musa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage-gated sodium channels and cancer: is excitability their primary role?

(2015) Sébastien Roger et al.   Frontiers in Pharmacology

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc

(2014) Esperanza Agullo-Pascual et al.   CARDIOVASCULAR RESEARCH

PDZ Domain–Binding Motif Regulates Cardiomyocyte Compartment-Specific Na V 1.5 Channel Expression and Function

(2014) Diana Shy et al.   CIRCULATION

Ankyrin-G Coordinates Intercalated Disc Signaling Platform to Regulate Cardiac Excitability In Vivo

(2014) Michael A. Makara et al.   CIRCULATION RESEARCH

Mitochondria and arrhythmias

(2014) Kai-Chien Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss-of-Function of the Voltage-Gated Sodium Channel NaV1.5 (Channelopathies) in Patients With Irritable Bowel Syndrome

(2014) Arthur Beyder et al.   GASTROENTEROLOGY

Scn1bdeletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

(2014) Xianming Lin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels

(2013) Indra Lübkemeier et al.   BASIC RESEARCH IN CARDIOLOGY

Late Sodium Current Inhibition in Acquired and Inherited Ventricular (dys)function and Arrhythmias

(2013) Carol Ann Remme et al.   CARDIOVASCULAR DRUGS AND THERAPY

Missense Mutations in Plakophilin-2 Cause Sodium Current Deficit and Associate With a Brugada Syndrome Phenotype

(2013) Marina Cerrone et al.   CIRCULATION

Super-resolution Scanning Patch Clamp Reveals Clustering of Functional Ion Channels in Adult Ventricular Myocyte

(2013) Anamika Bhargava et al.   CIRCULATION RESEARCH

Reduced Sodium Channel Function Unmasks Residual Embryonic Slow Conduction in the Adult Right Ventricular Outflow Tract

(2013) Bas J. Boukens et al.   CIRCULATION RESEARCH

Fibroblast Growth Factor Homologous Factors Modulate Cardiac Calcium Channels

(2013) Jessica A. Hennessey et al.   CIRCULATION RESEARCH

Ventricular dysfunction in a family with long QT syndrome type 3

(2013) Yoran M. Hummel et al.   EUROPACE

Cardiomyocyte FGF signaling is required for Cx43 phosphorylation and cardiac gap junction maintenance

(2013) Takashi Sakurai et al.   EXPERIMENTAL CELL RESEARCH

SCN5A mutation in Chinese patients with arrhythmogenic right ventricular dysplasia

(2013) J. Yu et al.   HERZ

Distribution and function of sodium channel subtypes in human atrial myocardium

(2013) Susann G. Kaufmann et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The late Na current as a therapeutic target: Where are we?

(2013) Lars S. Maier et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease

(2013) Karl Toischer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Coxsackie and Adenovirus Receptor Is a Modifier of Cardiac Conduction and Arrhythmia Vulnerability in the Setting of Myocardial Ischemia

(2013) Roos F.J. Marsman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Noncanonical Roles of Voltage-Gated Sodium Channels

(2013) Joel A. Black et al.   NEURON

Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: The multiple pool model

(2012) Diana Shy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes

(2012) Stefania Rizzo et al.   CARDIOVASCULAR RESEARCH

Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency

(2012) Marina Cerrone et al.   CARDIOVASCULAR RESEARCH

Voltage-gated sodium channels and metastatic disease

(2012) William J. Brackenbury   Channels

Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Regulates Cardiac Sodium Channel NaV1.5 Gating by Multiple Phosphorylation Sites

(2012) Nicole M. Ashpole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A distinctde novoexpression of Nav1.5 sodium channels in human atrial fibroblasts differentiated into myofibroblasts

(2012) Aurélien Chatelier et al.   JOURNAL OF PHYSIOLOGY-LONDON

A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells

(2012) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Electrophysiological Patterning of the Heart

(2012) Bastiaan J. Boukens et al.   PEDIATRIC CARDIOLOGY

A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype

(2012) Pascal Gosselin-Badaroudine et al.   PLoS One

Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia

(2012) M. L. Milstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice

(2011) Lina Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Extracellular Proton Modulation of the Cardiac Voltage-Gated Sodium Channel, NaV1.5

(2011) D.K. Jones et al.   BIOPHYSICAL JOURNAL

Biology of cardiac sodium channel Nav1.5 expression

(2011) M. B. Rook et al.   CARDIOVASCULAR RESEARCH

Interactions Between Ankyrin-G, Plakophilin-2, and Connexin43 at the Cardiac Intercalated Disc

(2011) Priscila Y. Sato et al.   CIRCULATION RESEARCH

MOG1

(2011) Darouna Kattygnarath et al.   Circulation-Cardiovascular Genetics

Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes

(2011) Xianming Lin et al.   HEART RHYTHM

Ca2+-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling

(2011) Donald M. Bers   HEART RHYTHM

Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmia

(2011) Lisa L. Murphy et al.   HEART RHYTHM

SCN5A Mutations Associate With Arrhythmic Dilated Cardiomyopathy and Commonly Localize to the Voltage-Sensing Mechanism

(2011) William P. McNair et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of ranolazine in angina, heart failure, arrhythmias, and diabetes

(2011) Samuel Sossalla et al.   PHARMACOLOGY & THERAPEUTICS

Na+ Channel ? Subunits: Overachievers of the Ion Channel Family

(2011) William J. Brackenbury et al.   Frontiers in Pharmacology

REVIEW: Sodium Channel (Dys)Function and Cardiac Arrhythmias

(2010) Carol Ann Remme et al.   Cardiovascular Therapeutics

Trafficking Defects and Gating Abnormalities of a Novel SCN5A Mutation Question Gene-Specific Therapy in Long QT Syndrome Type 3

(2010) Yanfei Ruan et al.   CIRCULATION RESEARCH

Voltage-Gated Sodium Channels Are Required for Heart Development in Zebrafish

(2010) Sameer S. Chopra et al.   CIRCULATION RESEARCH

Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel

(2010) Man Liu et al.   CIRCULATION RESEARCH

SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Na v 1.5 in Cardiomyocytes

(2010) Séverine Petitprez et al.   CIRCULATION RESEARCH

A βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice

(2010) Thomas J. Hund et al.   JOURNAL OF CLINICAL INVESTIGATION

Solution NMR Structure of Apo-Calmodulin in Complex with the IQ Motif of Human Cardiac Sodium Channel NaV1.5

(2010) Benjamin Chagot et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

(2010) Arthur Beyder et al.   JOURNAL OF PHYSIOLOGY-LONDON

Variable Nav1.5 Protein Expression from the Wild-Type Allele Correlates with the Penetrance of Cardiac Conduction Disease in the Scn5a+/− Mouse Model

(2010) Anne-Laure Leoni et al.   PLoS One

The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium

(2009) C. A. Remme et al.   BASIC RESEARCH IN CARDIOLOGY

Gain-of-function mutation of Na v 1.5 in atrial fibrillation enhances cellular excitability and lowers the threshold for action potential firing

(2009) Qiuju Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss-of-function mutation of the SCN3B-encoded sodium channel  3 subunit associated with a case of idiopathic ventricular fibrillation

(2009) C. R. Valdivia et al.   CARDIOVASCULAR RESEARCH

Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes

(2009) Priscila Y. Sato et al.   CIRCULATION RESEARCH

Ion Channel Transcript Expression at the Rabbit Atrioventricular Conduction Axis

(2009) Ian D. Greener et al.   Circulation-Arrhythmia and Electrophysiology

Mutations in Sodium Channel β1- and β2-Subunits Associated With Atrial Fibrillation

(2009) Hiroshi Watanabe et al.   Circulation-Arrhythmia and Electrophysiology

A Mutation in the β3 Subunit of the Cardiac Sodium Channel Associated With Brugada ECG Phenotype

(2009) Dan Hu et al.   Circulation-Cardiovascular Genetics

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

(2009) Jamie D. Kapplinger et al.   HEART RHYTHM

Mechanism of right precordial ST-segment elevation in structural heart disease: Excitation failure by current-to-load mismatch

(2009) Mark G. Hoogendijk et al.   HEART RHYTHM

LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice

(2009) Teng Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells

(2009) Ludovic Gillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine

(2009) N. Lindegger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac sodium channel Nav1.5 and interacting proteins: Physiology and pathophysiology

(2009) Hugues Abriel   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sodium channel mutations and arrhythmias

(2009) Yanfei Ruan et al.   Nature Reviews Cardiology

Voltage-gated Na+ channel transcript patterns in the mammalian heart are species-dependent

(2009) Steve Blechschmidt et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences

(2008) Victor A. Maltsev et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes

(2008) Simona Casini et al.   CARDIOVASCULAR RESEARCH

NFAT-Dependent Excitation–Transcription Coupling in Heart

(2008) Luis F. Santana   CIRCULATION RESEARCH

Molecular and Clinical Characterization of a Novel SCN5A Mutation Associated With Atrioventricular Block and Dilated Cardiomyopathy

(2008) Junbo Ge et al.   Circulation-Arrhythmia and Electrophysiology

Dilated Cardiomyopathy due to Sodium Channel Dysfunction

(2008) Connie R. Bezzina et al.   Circulation-Arrhythmia and Electrophysiology

α-1-Syntrophin Mutation and the Long-QT Syndrome

(2008) Geru Wu et al.   Circulation-Arrhythmia and Electrophysiology

Solution NMR Structure of the C-terminal EF-hand Domain of Human Cardiac Sodium Channel NaV1.5

(2008) Benjamin Chagot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G

(2008) Aline Bréchet et al.   JOURNAL OF CELL BIOLOGY

A Novel SCN5A Gain-of-Function Mutation M1875T Associated With Familial Atrial Fibrillation

(2008) Takeru Makiyama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Divergent Biophysical Defects Caused by Mutant Sodium Channels in Dilated Cardiomyopathy With Arrhythmia

(2007) Thao P. Nguyen et al.   CIRCULATION RESEARCH