Article
Genetics & Heredity
Yan Zhou, Qi Tian, Huan Gao, Lizhe Zhu, Jiao Yang, Juan Zhang, Jin Yang
Summary: By analyzing gene expression and immune cells, this study found a correlation between immune-related genes and immune cells with the response to neoadjuvant chemotherapy in breast cancer, highlighting the significance of combining neoadjuvant chemotherapy with immunotherapy for better clinical benefits.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Jae Hun Shin, Jaekwang Jeong, Stephen E. Maher, Heon-Woo Lee, Jaechul Lim, Alfred L. M. Bothwell
Summary: Cancer cells acquire lymphocyte membrane proteins through trogocytosis, leading to an immunosuppressive tumor microenvironment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Keita Takahashi, Yuki Sakashita, Mutsunori Murahashi, Hoshiho Kubota, Masayuki Shimoda, Yoshitaka Ishikawa, Yuichiro Tanishima, Takanori Kurogochi, Fumiaki Yano, Ken Eto
Summary: Low levels of TI CD8+ cells were found to be a significant prognostic factor for patients with ESCC undergoing neoadjuvant DCF therapy followed by esophagectomy.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jose Manuel Casanova, Jani-Sofia Almeida, John David Reith, Luana Madalena Sousa, Ruben Fonseca, Paulo Freitas-Tavares, Manuel Santos-Rosa, Paulo Rodrigues-Santos
Summary: Osteosarcoma is a common high-grade primary bone tumor that mainly affects young adults. The presence of tumor-infiltrating CD4+ cells is protective for patients, while CD8+ cells have a significant impact on overall survival and progression-free survival. There is a strong association between tumor-infiltrating CD4+ cells and CD44s expression in tumor samples, highlighting the importance of considering TIL and tumor markers for improving OST treatment.
Article
Genetics & Heredity
Lien-Hung Huang, Ting-Min Hsieh, Chun-Ying Huang, Yueh-Wei Liu, Shao-Chun Wu, Peng-Chen Chien, Ching-Hua Hsieh
Summary: Hepatocellular carcinoma is the most common cause of primary liver cancer deaths worldwide, with major risk factors including cirrhosis, hepatitis B virus, hepatitis C virus infection, and chronic alcohol abuse. Differences in gene expression profiles and infiltrating immune cells between Asian and non-Asian patients with HCC were found in this study, potentially leading to improvements in prognosis prediction and therapeutic targeting.
Review
Medicine, General & Internal
Iman M. M. Talaat, Noha M. M. Elemam, Shroque Zaher, Maha Saber-Ayad
Summary: Colorectal cancer is a prevalent cancer type worldwide, and the immune cells within the tumor microenvironment play a crucial role in its initiation and progression. Immune checkpoint molecules are highlighted as potential targets for immunotherapy in colorectal cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Yi He, Haiting Zhou, Xiaojian Huang, Yunkun Qu, Yingguang Wang, Wenbin Pei, Rui Zhang, Sheng Chen, Hongbo You
Summary: In this study, we identified a TME-related gene, LPAR5, which is highly correlated with prognosis and metastasis in osteosarcoma. LPAR5(+) macrophages play an important role in the tumor microenvironment of osteosarcoma and may serve as a prognostic factor and therapeutic target. The expression of LPAR5 is positively correlated with immune cells, especially macrophages, and LPAR5 high expression is associated with better prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Max Heiduk, Ioana Plesca, Jessica Glueck, Luise Mueller, David Digomann, Charlotte Reiche, Janusz von Renesse, Rahel Decker, Christoph Kahlert, Ulrich Sommer, Daniela E. Aust, Marc Schmitz, Juergen Weitz, Lena Seifert, Adrian M. Seifert
Summary: This study found that neoadjuvant chemotherapy can increase the density of T cells within the tumor and alter the cytokine production. This suggests that combining immunotherapy with neoadjuvant regimens may improve treatment outcomes and prognosis of pancreatic cancer.
Article
Genetics & Heredity
Juexing Li, Lei Zhou, Zhenhua Li, Shangneng Yang, Liangyue Tang, Hui Gong
Summary: Weighted gene co-expression network analysis revealed crucial hub genes and biological signaling pathways associated with SIC. The hub genes were found to be closely related to cardiac metabolism and cell death processes in SIC patients, suggesting potential new targets and therapeutic strategies for the treatment of SIC.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
G. Griguolo, G. Serna, T. Pascual, R. Fasani, X. Guardia, N. Chic, L. Pare, S. Pernas, M. Munoz, M. Oliveira, M. Vidal, A. Llombart-Cussac, J. Cortes, P. Galvan, B. Bermejo, N. Martinez, R. Lopez, S. Morales, I Garau, L. Manso, J. Alarcon, E. Martinez, P. Villagrasa, A. Prat, P. Nuciforo
Summary: In HER2+ breast cancer, changes in the density of immune cells in the tumor microenvironment after anti-HER2 treatment, particularly those interacting spatially with tumor cells, are associated with treatment response. Furthermore, patients achieving pathologic complete response show a consistent decrease in stromal tumor-infiltrating lymphocytes (sTILs) post-surgery, while residual tumors often remain inflamed, suggesting a progressive loss of T cell function. Understanding the implications of the resulting immunosuppressive microenvironment is crucial for developing effective strategies for early-stage HER2+ breast cancer therapy.
NPJ PRECISION ONCOLOGY
(2021)
Article
Oncology
Kim R. M. Blenman, Michal Marczyk, Thomas Karn, Tao Qing, Xiaotong Li, Vignesh Gunasekharan, Vesal Yaghoobi, Yalai Bai, Eiman Y. Ibrahim, Tristen Park, Andrea Silber, Denise M. Wolf, Emily Reisenbichler, Carsten Denkert, Bruno V. Sinn, Mariya Rozenblit, Julia Foldi, David L. Rimm, Sibylle Loibl, Lajos Pusztai
Summary: This study examined gene expression, germline variant, and somatic mutation features associated with pathologic response to neoadjuvant durvalumab plus chemotherapy in basal-like triple-negative breast cancer. The results showed differences in gene expression and pathway enrichment between cases with different pathologic responses, with immune-rich cases being associated with macrophages, activated B cells, and T cells, while immune-poor cases were associated with other signaling pathways. The findings contribute to a better understanding and prediction of the efficacy of this treatment regimen.
CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Nana Zhang, Depu Wang, Xiaoyan Hu, Guanjun Zhang, Zhuoqun Li, Yan Zhao, Zhijun Liu, Yili Wang
Summary: This study investigates the correlation between tumor infiltration pattern and immune status in gastric cancer. The results suggest that an aggressive growth pattern of the tumor, especially originating from the proximal site, is associated with a weak immune response and poor prognosis. The density and subtype of tumor-infiltrating lymphocytes also differ in various differentiated areas of the tumor tissue. The study provides a new perspective for understanding the biological behavior of gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jin Hong, Weiwei Rui, Xiaochun Fei, Xiaosong Chen, Kunwei Shen
Summary: This study found that pre-NAC TIL level can predict pCR and DFS in breast cancer patients receiving NAC. For patients without pCR, pre-NAC TIL and TIL category change, but not post-NAC TIL, were significantly associated with DFS.
Article
Respiratory System
Zhuang Tong, Xu Wang, Hongyu Liu, Jian Ding, Yinling Chu, Xin Zhou
Summary: This study investigates the correlation between tumor-infiltrating immune cells and the prognosis and clinical characteristics of LUAD patients. Based on the analysis of transcriptome data and immune cell abundance, a predictive model using immune cells is established and validated. Furthermore, higher expressions of TNF-alpha, IL-8, IL-6, and IFN-gamma are observed in tumor tissues compared to adjacent tissues.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Oncology
David Restle, Joseph Dux, Xiaoyu Li, Alexander J. Byun, Jennie K. Choe, Yan Li, Raj G. Vaghjiani, Carlos Thomas, Kyohei Misawa, Kay See Tan, David R. Jones, Navin K. Chintala, Prasad S. Adusumilli
Summary: In patients with lung adenocarcinoma, brain metastases have a more immune-suppressive tumor immune microenvironment compared to other metastases. Majority of patients with antigen expression in the primary tumor also have antigen expression in the metastases, although with heterogeneous intensity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Neurosciences
Yanyang Xu, Ying Yan, Mintong He, Zhiheng Liao, Dongzhi Ran, Xicui Sun, Yulou Liu, Xutian Wang, Yingcheng Huang, Hanhong Xu, Huaiyu Gu
NEUROSCIENCE LETTERS
(2015)
Article
Oncology
Yi-jiang Song, Yanyang Xu, Xiaojun Zhu, Jianchang Fu, Chuangzhong Deng, Hongmin Chen, Huaiyuan Xu, Guohui Song, Jinchang Lu, Qinglian Tang, Jin Wang
FRONTIERS IN ONCOLOGY
(2020)
Article
Immunology
Yi-Jiang Song, Yanyang Xu, Chuangzhong Deng, Xiaojun Zhu, Jianchang Fu, Hongmin Chen, Jinchang Lu, Huaiyuan Xu, Guohui Song, Qinglian Tang, Jin Wang
Summary: This study established a new classification system for osteosarcoma based on the gene expression profile of the tumor microenvironment, identifying two molecular subtypes associated with prognosis, S1 (infiltration type) and S2 (escape type). The study found that immune and stromal infiltrates were more abundant in subtype S1 compared to subtype S2, and certain immune checkpoint markers were associated with prognosis in subtype S1. Furthermore, the study confirmed the results using a validation set and assessed correlations between fibroblast percentage and clinical responses to chemotherapy in osteosarcoma primary tumors.
FRONTIERS IN IMMUNOLOGY
(2021)