Combined blockade of TGf-β1 and GM-CSF improves chemotherapeutic effects for pancreatic cancer by modulating tumor microenvironment

Low CD8+ T Cell Infiltration and High PD-L1 Expression Are Associated with Level of CD44+/CD133+ Cancer Stem Cells and Predict an Unfavorable Prognosis in Pancreatic Cancer

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Cancer statistics, 2018

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Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease

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Therapeutic developments in pancreatic cancer: current and future perspectives

(2018) John P. Neoptolemos et al.   Nature Reviews Gastroenterology & Hepatology

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

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Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial

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The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

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Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells

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Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

(2016) Avery D. Posey et al.   IMMUNITY

Human macrophages induce CD4+ Foxp3+ regulatory T cells via binding and re-release of TGF-β

(2016) Angelika Schmidt et al.   IMMUNOLOGY AND CELL BIOLOGY

Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages

(2016) Qiaofei Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo

(2016) Giacomo Casella et al.   Journal of Neuroinflammation

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

(2016) Sebastian R. Nielsen et al.   NATURE CELL BIOLOGY

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

(2015) E. Van Overmeire et al.   CANCER RESEARCH

Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

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Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer

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Stromal biology and therapy in pancreatic cancer: a changing paradigm

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Understanding Local Macrophage Phenotypes In Disease: Modulating macrophage function to treat cancer

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T cell exclusion, immune privilege, and the tumor microenvironment

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Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

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Evolution of the Cancer Stem Cell Model

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Tumor-Associated Macrophages: From Mechanisms to Therapy

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Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

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Macrophage Regulation of Tumor Responses to Anticancer Therapies

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Biology and Clinical Applications of Pancreatic Cancer Stem Cells

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Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma

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Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

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Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

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CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

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Cisplatin Treatment Induces a Transient Increase in Tumorigenic Potential Associated with High Interleukin-6 Expression in Head and Neck Squamous Cell Carcinoma

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