Article
Otorhinolaryngology
Ariel E. Pollock, Danielle Arons, Gregory S. Alexander, David Alicia, Kayla M. Birkman, Jason K. Molitoris, Ranee Mehra, Kevin J. Cullen, Kyle M. Hatten, Rodney J. Taylor, Jeffrey S. Wolf, William F. Regine, Matthew E. Witek
Summary: A retrospective analysis showed that the extent of high-dose gross tumor volume (GTV) to clinical target volume (CTV) expansion is associated with local control in patients with p16-positive oropharynx cancer (p16+ OPC) treated with intensity modulated proton therapy (IMPT). Excellent local control was achieved using IMPT for p16+ OPC independent of GTV expansion.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Health Care Sciences & Services
Dorota Maria Borowicz, Konstantin N. Shipulin, Gennady V. Mytsin, Agnieszka Skrobala, Piotr Milecki, Victor N. Gayevsky
Summary: Comparison between passive scattering (PS) and intensity-modulated proton therapy (IMPT) for ultra-hypofractionated proton therapy in localized prostate cancer (PCa) showed that IMPT provided better target coverage and lower mean doses to the rectum and bladder compared to PS. However, PS had a slightly better performance in high dose distribution to the rectum. There were no significant differences in mean conformity index values and gamma index between the two treatment methods.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Kishan J. Pithadia, Pragati G. Advani, Deborah E. Citrin, Justin E. Bekelman, Diana R. Withrow, Amy Berrington de Gonzalez, Lindsay M. Morton, Sara J. Schonfeld
Summary: A retrospective cohort study found that intensity-modulated radiotherapy (IMRT) for prostate cancer is not associated with an increased risk of second primary cancers. Any inverse associations may be correlated with the calendar year of treatment.
Article
Oncology
Fen Xue, Xiaoshuang Niu, Chaosu Hu, Xiayun He
Summary: This study aimed to determine the long-term risk of second primary lung adenocarcinoma (SPLAC) in nasopharyngeal cancer (NPC) patients after intensity-modulated radiotherapy (IMRT). The results showed that the incidence of SPLAC in NPC patients after IMRT was similar to that of the normal population, and most cases were detected in early stages during follow-up, with good surgical efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Robert W. Gao, David M. Routman, William S. Harmsen, Sasha Ebrahimi, Robert L. Foote, Daniel J. Ma, Michelle Neben-Wittich, Lisa A. McGee, Samir H. Patel, Eric J. Moore, Garret W. Choby, Kendall K. Tasche, Katharine A. Price, Mauricio E. Gamez, Scott C. Lester
Summary: This study evaluates radiotherapy techniques and recurrence patterns for adenoid cystic carcinoma of the head and neck. It found that modern conformal radiotherapy leads to low rates of recurrence. Higher doses of radiation (>60 Gy) postoperatively and definitively (70 Gy) may improve treatment outcomes. Selective omission of elective nodal treatment may be considered for suitable patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Jianzhong Cao, Xiaodong Zhang, Bo Jiang, Jiayun Chen, Xiaochun Wang, Li Wang, Narayan Sahoo, X. Ronald Zhu, Rong Ye, Pierre Blanchard, Adam S. Garden, C. David Fuller, G. Brandon Gunn, Steven J. Frank
Summary: The study showed that in patients with oropharyngeal cancer, IMPT treatment was associated with less late xerostomia compared to IMRT treatment. Dosimetric variables related to the oral cavity were associated with late xerostomia.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Han Gyul Yoon, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, Seyjoon Park
Summary: In treating oropharynx cancer patients, the combination of IMRT and IMPT achieved more favorable acute toxicity profiles compared to IMRT alone, while maintaining comparable oncologic outcomes.
Article
Oncology
Jing You, Shuchai Zhu, Jiancheng Li, Jie Li, Junyue Shen, Yidian Zhao, Xiaomin Li, Lin Jia, Qingshan Li, Jun Yang, Yiqun Wu, Wenbin Shen, Haishan Wu, Xueqin Wu, Xiaomin Wang, Yaqiong Ren, Jun He, Pingping Lin, Guangying Zhu, Anhui Shi
Summary: This study aimed to investigate whether a high dose of 59.4 Gy using intensity-modulated radiation therapy (IMRT) would improve survival without increasing toxicities in patients with esophageal cancer. The results showed that a high dose of radiation did not improve survival compared to the standard dose in patients with inoperable thoracic esophageal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Darren M. Zuro, Gabriel Vidal, James Nathan Cantrell, Yong Chen, Chunhui Han, Christina Henson, Salahuddin Ahmad, Susanta Hui, Imad Ali
Summary: The purpose of this study is to investigate the treatment planning of TMI using IMPT. The dosimetric parameters of IMPT plans were evaluated and compared with VMAT plans. The results showed significant reduction in organ-at-risk dose in IMPT plans compared to VMAT plans.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Michelle Oud, Sebastiaan Breedveld, Marta Gizynska, Michiel Kroesen, Stefan Hutschemaekers, Steven Habraken, Steven Petit, Zoltan Perko, Ben Heijmen, Mischa Hoogeman
Summary: This study proposes and evaluates a new approach in intensity modulated proton therapy, which involves the daily selection of plans from patient-specific pre-treatment established plan libraries for treatment. Compared to daily online re-planning, this approach is simpler and reduces the risk of xerostomia and dysphagia, while improving adherence to target coverage constraints.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
William T. Hrinivich, Heng Li, Anh Tran, Sahaja Acharya, Matthew M. Ladra, Khadija Sheikh
Summary: Intensity modulated proton therapy provides excellent normal tissue sparing for pediatric cancer treatment, but requires range shifter devices for shallow targets and small anatomy, which increases lateral scatter. This study presents the design, manufacturing, and characterization of a range shifter board that improves normal tissue sparing while minimizing lateral scatter, and compares it to standard range shifter planning approaches. Dosimetric measurements were performed to evaluate the device, and treatment plans from two pediatric patients were compared, showing significant reduction in lung and kidney dose compared to standard range shifter. This device is now in routine use at the clinic.
Article
Oncology
You-Ping Liu, Yi-Hui Wen, Jun Tang, Yi Wei, Rui You, Xiao-Lin Zhu, Jian Li, Lin Chen, Li Ling, Ning Zhang, Xiong Zou, Yi-Jun Hua, You-Mou Chen, Lei Chen, Li-Xia Lu, Ming-Yuan Chen, Wei-Ping Wen
Summary: Surgery significantly improved overall survival compared with IMRT in patients with resectable locally recurrent NPC. ENPG could be considered as the standard treatment option for this patient population, although long-term follow-up is needed to further determine the efficacy and toxicity of this strategy.
Article
Medicine, General & Internal
Brian Yu, Sung Jun Ma, Olivia Waldman, Cynthia Dunne-Jaffe, Udit Chatterjee, Lauren Turecki, Jasmin Gill, Keerti Yendamuri, Austin Iovoli, Mark Farrugia, Anurag K. Singh
Summary: This retrospective cohort study found that the use of intensity-modulated radiation therapy (IMRT) for postoperative radiation therapy (PORT) among patients with incompletely resected non-small cell lung cancer (NSCLC) increased in the US from 2004 to 2019. Furthermore, IMRT was associated with improved survival compared with 3D conformal radiation therapy (3DCRT).
Article
Oncology
Mehdi Varmaghani, Malihe Amiri, Hossein Ebrahimpour, Roham Salek, Javad Javan-Noughabi
Summary: This study compared the cost-effectiveness of intensity-modulated radiation therapy and three-dimensional conformal radiotherapy for head and neck cancer treatment in east of Iran. The results showed that three-dimensional conformal radiotherapy was more cost-effective and saved more quality-adjusted life years than intensity-modulated radiotherapy.
RADIATION ONCOLOGY
(2023)
Review
Oncology
Sabah Falek, Rajesh Regmi, Joel Herault, Melanie Dore, Anthony Vela, Pauline Dutheil, Cyril Moignier, Pierre-Yves Marcy, Julien Drouet, Arnaud Beddok, Noah E. Letwin, Joel Epstein, Upendra Parvathaneni, Juliette Thariat
Summary: Metallic restorations may have a more severe impact on the quality of proton therapy compared to photon radiotherapy. Multidisciplinary assessment is required before proton therapy to evaluate metal-induced errors and make decisions regarding the conservation/removal of dental metals and the optimal radiotherapy approach.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Jacob A. Miller, Diego A. S. Toesca, J. Richelcyn M. Baclay, Lucas K. Vitzthum, Piotr Dubrowski, Erqi L. Pollom, Daniel T. Chang
Summary: Through a retrospective study on pancreatic SBRT treatment, it was found that the addition of elective nodal irradiation (ENI) to pancreatic SBRT can reduce locoregional progression, but it does not improve survival. The combination treatment has a certain impact on acute toxicity, but late and serious toxicity remain similar.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Michael Xiang, Albert J. Chang, Karim Chamie, Alexandra Drakaki, Erqi L. Pollom, Michael L. Steinberg, Amar U. Kishan
Summary: The utilization of hypofractionated radiation therapy (HFRT) and intensity-modulated radiation therapy (IMRT) in bladder cancer patients is low, with significant underuse of chemotherapy in HFRT. However, the use of HFRT and IMRT has been increasing over time. IMRT is associated with similar or slightly increased survival, especially in patients receiving HFRT.
CLINICAL GENITOURINARY CANCER
(2022)
Meeting Abstract
Oncology
Erqi L. Pollom, Andrew Shelton, George A. Fisher, Jeffrey Bien, Daniel King, Tyler Paul Johnson, Christopher Chen, Shagufta Shaheen, Curtis Robert Chong, Lucas Vitzthum, Natalie Kirilcuk, Arden M. Morris, Cindy Kin, Aaron Dawes, Vipul Sheth, Vandana Sundaram, Eleanor Brown, Daniel Tandel Chang
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Hyunsoo Joshua No, Neelufar Raja, Rie Von Eyben, Millie Das, Mohana Roy, Nathaniel Myall, Joel Neal, Heather Wakelee, Alexander Chin, Maximilian Diehn, Billy Wiseman Loo, Daniel Tandel Chang, Erqi Liu Pollom, Lucas Kas Vitzthum
Summary: The purpose of this study was to evaluate the incidence of metastatic disease in non-small cell lung cancer (NSCLC) and to determine the prevalence of oligometastatic disease using recent clinical trial eligibility criteria. Results showed that approximately 48% of patients with metastatic NSCLC had ≤ 3 metastases at diagnosis, and 28% met the criteria for oligometastatic disease in clinical trials.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Caressa Hui, Richel Baclay, Kevin Liu, Navjot Sandhu, Phoebe Loo, Rie von Eyben, Chris Chen, Vipul Sheth, Lucas Vitzthum, Daniel Chang, Erqi Pollon
Summary: This study aimed to determine the optimal treatment for patients with locally advanced rectosigmoid cancers and explore the role of distance from the anal verge and anatomical landmarks in guiding treatment decisions. The study found that the peritoneal reflection (PR) may be a reliable landmark in addition to the distance from the anal verge to determine the most appropriate treatment option. Patients with tumors below the PR may benefit more from neoadjuvant therapy.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lianli Liu, Liyue Shen, Adam Johansson, James M. Balter, Yue Cao, Daniel Chang, Lei Xing
Summary: This study develops a geometry-informed deep learning framework for volumetric MRI with sub-second acquisition time to support 3D motion tracking. By incorporating geometric priors, the framework enables volumetric imaging with high spatial and temporal resolution, which is valuable for improving the precision of MRI-guided radiotherapy.
Editorial Material
Oncology
Caressa Hui, Lucas K. Vitzthum, Daniel T. Chang, Erqi L. Pollom
Summary: Trimodality therapy has shown excellent outcomes for locally advanced rectal cancer. Recent efforts aim to improve distant control and quality of life by using total neoadjuvant therapy and a watch-and-wait approach. This has raised uncertainties in the neoadjuvant treatment paradigm, which requires shared decision-making with patients.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Andressa Dias Costa, Sara A. Vayrynen, Akhil Chawla, Jinming Zhang, Juha P. Vayrynen, Mai Chan Lau, Hannah L. Williams, Chen Yuan, Vicente Morales-Oyarvide, Dalia Elganainy, Harshabad Singh, James M. Cleary, Kimberly Perez, Kimmie Ng, William Freed-Pastor, Joseph D. Mancias, Stephanie K. Dougan, Jiping Wang, Douglas A. Rubinson, Richard F. Dunne, Margaret M. Kozak, Lauren Brais, Emma Reilly, Thomas Clancy, David C. Linehan, Daniel T. Chang, Aram F. Hezel, Albert C. Koong, Andrew J. Aguirre, Brian M. Wolpin, Jonathan A. Nowak
Summary: This study investigates the impact of neoadjuvant chemotherapy on the tumor immune microenvironment in pancreatic ductal adenocarcinoma. The findings suggest that neoadjuvant chemotherapy can shift the immune microenvironment towards an anti-tumorigenic state and improve patient survival.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Ting Martin Ma, Felix Y. Feng, Seth A. Rosenthal, Matthew B. Rettig, Ann C. Raldow, Daniel E. Spratt, Michael Xiang, Amar U. Kishan
Summary: By comparing prostate cancer-specific mortality in patients from a real-world setting with those on a clinical trial, we found that trial patients had better outcomes, especially among Black patients, indicating significant racial disparities in the real world.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Daniel Pham, Eric Simiele, Dylan Breitkreutz, Dante Capaldi, Bin Han, Murat Surucu, Seyi Oderinde, Lucas Vitzthum, Michael Gensheimer, Hilary Bagshaw, Alex Chin, Lei Xing, D. T. Chang, Natalyia Kovalchuk
Summary: This study evaluated the treatment plan quality and delivery efficiency of the first clinical biology-guided radiation therapy system without PET guidance. The results showed that the plans generated with this system were generally superior to conventional methods for IMRT/SBRT cases.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Meeting Abstract
Oncology
Yufan Fred Wu, Chika Nwachukwu, Diego Toesca, Yufei Liu, Amanda Koong, Rie Von Eyben, Albert Koong, Daniel Chang
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
D. Pham, E. Simiele, D. Breitkreutz, D. Capaldi, O. Oderinde, B. Han, M. Surucu, L. Vitzthum, M. Gensheimer, H. Bagshaw, A. Chin, D. Chang, N. Kovalchuk
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
N. Kovalchuk, L. Vitzthum, D. Pham, C. Chuang, M. Gensheimer, A. Da Silva, B. Han, D. Chang, M. Surucu
Article
Oncology
Quaovi H. Sodji, Dhanya K. Nambiar, Vignesh Viswanathan, Rie von Eyben, Deana Colburg, Michael S. Binkley, Caiyun G. Li, Monica M. Olcina, Daniel T. Chang, Quynh-Thu Le, Amato J. Giaccia
CANCER RESEARCH COMMUNICATIONS
(2022)
Meeting Abstract
Oncology
Chris Javadi, Julia Chang, Erna Forgo, M. Usman Ahmad, George A. Fisher, Daniel T. Chang, Daniel J. Delitto, Monica M. Dua, Byrne Lee, Brendan C. Visser, Jeffrey A. Norton, George A. Poultsides
ANNALS OF SURGICAL ONCOLOGY
(2022)