Journal
CELL
Volume 164, Issue 4, Pages 599-600Publisher
CELL PRESS
DOI: 10.1016/j.cell.2016.01.030
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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Cells communicate with their environment, in part, through cell surface receptors. Engineering receptors that both sense arbitrary inputs and provide outputs orthogonal to endogenous signaling pathways has been a challenge. Now, Lim and colleagues report a system based on synthetic Notch receptors that allows independent control of both inputs and outputs in diverse cell types.
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