Article
Oncology
Xiao-Dong Zhu, Li-Xiang Zhang, Pan-Quan Luo, Hai Zhu, Zhi-Jian Wei, A-Man Xu
Summary: This study found that the elevation of tumor markers CEA and CA19-9 before and after gastric cancer surgery is associated with poor prognosis, and this increment has a greater impact on prognosis than preoperative CEA/CA19-9 levels. A new prognostic model was established and shown to have reliable accuracy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Immunology
Qiu-Yue Han, Xia Zhang, Jian-Gang Zhang, Wen-Jun Zhou, Qiong-Yuan Chen, Yuan-Yuan Chen, Wei-Hua Yan, Aifen Lin
Summary: Pre-operative NLR is an independent prognostic factor for patients with gastric cancer and has stratified prognostic value for patients with AJCC stage III.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Manman Xu, Liang Zhang, Juan Wang, Longyang Cheng, Chunlei Chen, Shaoya Li, Haibin Dai, Penglai Zhao, Chunhua Hang
Summary: This study explored the association between pre-operative prognostic nutrition index (PNI) and post-operative pneumonia (POP) in aneurysmal subarachnoid hemorrhage (aSAH) patients. The results showed that lower pre-operative PNI levels were associated with a higher incidence of POP. Therefore, neurosurgeons should pay more attention to the pre-operative nutrition status of aSAH patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Ruolan Zhang, Can Hu, Jiaqing Zhang, Yanqiang Zhang, Li Yuan, Pengcheng Yu, Yi Wang, Zhehan Bao, Mengxuan Cao, Rongwei Ruan, Xiangdong Cheng, Zhiyuan Xu
Summary: This study analyzed the significance of inflammatory and nutritional marker alterations during neoadjuvant chemotherapy in long-term prognosis of advanced gastric cancer patients. The results showed that several biomarkers changed during NACT and were associated with overall survival. PLR (alpha) may be a reliable marker for predicting prognosis.
Article
Medicine, Research & Experimental
Hee Young Na, Yujun Park, Soo Kyung Nam, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Kyu Sang Lee, Hye Seung Lee
Summary: The study using mIHC revealed that although the number of CD57+ NK cells was lower, they played a critical role in the prognosis of gastric cancer along with macrophages and T cells. Higher density of CD57+ NK cells was associated with inferior survival, suggesting they may be potential targets in GC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Jiang Chen, Cheng-Zhi Wei, Jun Lin, Ruo-Peng Zhang, Guo-Ming Chen, Yuan-Fang Li, Run-Cong Nie, Yong-Ming Chen
Summary: This study analyzed the relationship between PD-L1 expression and prognosis in gastric cancer patients with peritoneal metastasis, and found that high PD-L1 expression was associated with better prognosis.
Article
Oncology
Meeri Kastinen, Paeivi Sirnio, Hanna Elomaa, Maarit Ahtiainen, Sara A. Vayrynen, Karl-Heinz Herzig, Sanna Merilainen, Raila Aro, Reetta Haivala, Tero Rautio, Juha Saarnio, Erkki-Ville Wirta, Olli Helminen, Toni T. Seppala, Teijo Kuopio, Jan Bohm, Anne Tuomisto, Jukka-Pekka Mecklin, Markus J. Makinen, Juha P. Vayrynen
Summary: This study analyzed data from 1413 patients with colorectal cancer and found associations between tumor necrosis percentage and tumor characteristics, immune cell infiltrates, serum cytokine concentrations, as well as prognosis. The results showed that high tumor necrosis percentage is associated with shorter colorectal cancer-specific survival, independent of other factors. Tumor necrosis is therefore considered an important prognostic factor in colorectal cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Yoh-ichiro Iwasa, Moeka Shimizu, Kazuki Matsuura, Kentaro Hori, Ken Hiramatsu, Kenjiro Sugiyama, Yoh Yokota, Tomohiro Kitano, Ryosuke Kitoh, Yutaka Takumi
Summary: This study aimed to investigate the prognostic value of hematological biomarkers measured before and after treatment in patients with head and neck cancer (HNC). The pretreatment C-reactive protein/albumin ratio (pre-CAR) and post-treatment prognostic nutritional index (post-PNI) showed the highest area under the curve with cutoff values of 0.0945 and 34.9, respectively.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Lucy X. Ma, Kirsty Taylor, Osvaldo Espin-Garcia, Reut Anconina, Chihiro Suzuki, Michael J. Allen, Marta Honorio, Yvonne Bach, Frances Allison, Eric X. Chen, Savtaj Brar, Carol J. Swallow, Jonathan Yeung, Gail E. Darling, Rebecca Wong, Sangeetha N. Kalimuthu, Raymond W. Jang, Patrick Veit-Haibach, Elena Elimova
Summary: In de novo metastatic GE adenocarcinoma patients, ECOG, baseline NRI, and change in NRI during treatment were significant prognostic factors for overall survival, while sarcopenia was not. The use of NRI at baseline and during treatment can provide valuable prognostic information.
Article
Medicine, Research & Experimental
Hao Liao, Jiayang Zhang, Tiantian Zheng, Xiaoran Liu, Jianxin Zhong, Bin Shao, Xiaoxi Dong, Xiaohong Wang, Pan Du, Bonnie L. King, Shidong Jia, Jianjun Yu, Huiping Li
Summary: This study revealed the molecular profiles of Chinese patients with advanced breast cancer (ABC) and highlighted the clinical importance of ctDNA-derived markers for predicting treatment response, prognosis, and disease progression. Common gene mutations included TP53 and PIK3CA, while frequent CNVs included amplifications of ERBB2 and FGFR1. Furthermore, TP53 and PIK3CA mutations were associated with survival outcomes in triple-negative breast cancer (TNBC) patients, and high ctDNA fraction and blood-based tumor mutation burden (bTMB) were associated with progression-free survival (PFS) in TNBC and HER2+ patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Physiology
Jian Liu, Shiqi Liu, Longfei Gao, Guangqiao Li, Jie Xu, Yilin Sun, Jingfeng Wang, Bo Shi
Summary: This study aimed to evaluate the feasibility of using pre-operative heart rate variability (HRV) parameters to predict post-operative blood inflammatory biomarkers in patients with cervical cancer. Results showed that pre-operative SD2 was significantly associated with post-operative PLR, while LF/HF was significantly correlated with NLR. These findings suggest that pre-operative HRV parameters may potentially predict post-operative inflammation and help in clinical treatment decisions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Qinglian He, Ziqi Li, Jinbao Yin, Yuling Li, Yuting Yin, Xue Lei, Wei Zhu
Summary: A prognostic risk assessment model based on 11 autophagy-associated genes was successfully constructed in colorectal cancer (CRC), providing valuable insights into predicting survival outcomes for CRC patients. The model showed significant enrichment in tumor-relevant pathways and biological processes, offering new directions for evaluating prognosis and guiding treatment strategies for CRC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Jiarong Huang, Jinxuan Song, Xiangyu Li, Shuangfei Liu, Wentao Huang, Ziyi Shen, Yan Cheng, Shien Kou, Zhenguo Gao, Yunhong Tian, Jiani Hu
Summary: Studies suggest that m6A-related lncRNAs may play a crucial role in the prognosis of gastric cancer patients and the tumor immune microenvironment, with two distinct immune phenotypes observed in different clusters, and poor prognosis seen in the high-risk group.
BMC MEDICAL GENOMICS
(2022)
Article
Nutrition & Dietetics
Jianping Xiong, Yunzi Wu, Haitao Hu, Wenzhe Kang, Yang Li, Peng Jin, Xinxin Shao, Weikun Li, Yantao Tian
Summary: This study aimed to assess the role of CT-determined sarcopenia in the prognosis of patients with gastric cancer liver metastases (GCLM) receiving hepatectomy. The results showed that sarcopenia was associated with age, BMI, and number of liver metastases, and had a significant impact on recurrence-free survival (RFS). Therefore, customized treatment should be applied to patients with sarcopenia.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Xuan Wang, Keying Che, Tao Shi, Qin Liu, Xinyun Xu, Hongyan Wu, Lixia Yu, Baorui Liu, Jia Wei
Summary: This study explored the relationship between ARID1A expression and systemic inflammatory response (SIR), and investigated the prognostic value of ARID1A expression in gastric cancer (GC). The loss of ARID1A protein expression was associated with specific subtypes of GC and high expression of immune therapy markers. The expression of ARID1A protein had important prognostic significance in GC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Surgery
Jun Lu, Zhen Xue, Bin-Bin Xu, Dong Wu, Hua-Long Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Ping Li, Chang-Ming Huang, Chao-Hui Zheng
Summary: The artificial neural network model developed in this study can accurately predict the potential benefits of adjuvant chemotherapy in patients with stage II/III gastric cancer. It shows good prediction accuracy and prognostic stratification ability for the potential benefits of chemotherapy.
Article
Surgery
Jianzhang Wu, Zhaoqing Tang, Gang Zhao, Lu Zang, Ziyu Li, Weidong Zang, Zhengrong Li, Jianjun Qu, Su Yan, Chaohui Zheng, Gang Ji, Linghua Zhu, Yongliang Zhao, Jian Zhang, Hua Huang, Yingxue Hao, Lin Fan, Hongtao Xu, Yong Li, Li Yang, Wu Song, Jiaming Zhu, Wenbin Zhang, Minzhe Li, Xinyu Qin, Fenglin Liu
Summary: The study aims to determine the incidence of clinically relevant postoperative pancreatic fistula (CR-POPF) and identify independent risk factors. Analysis of 2089 cases found that LigaSure usage and pTNM III were independent risk factors of CR-POPF. Surgery procedure, LigaSure usage, and measuring D-AMY on postoperative day 3 showed potential for early identification of CR-POPF.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Medicine, Research & Experimental
Qi-Yue Chen, Xiao-Bo Huang, Ya-Jun Zhao, Hua-Gen Wang, Jia-Bin Wang, Li-Chao Liu, Ling-Qian Wang, Qing Zhong, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li, Chang-Ming Huang
Summary: This study identified a decrease in FABP4 expression as a potential marker for gastric cancer (GC) metastasis and poor prognosis. Mechanistically, FABP4 inhibited GC metastasis by binding with PPAR-gamma and suppressing CADM3 transcription. The antidiabetic drug rosiglitazone showed therapeutic potential in restoring PPAR-gamma/CADM3 activation in FABP4-deficient GC cells.
Article
Surgery
Changming Huang, Hao Liu, Yanfeng Hu, Yihong Sun, Xiangqian Su, Hui Cao, Jiankun Hu, Kuan Wang, Jian Suo, Kaixiong Tao, Xianli He, Hongbo Wei, Mingang Ying, Weiguo Hu, Xiaohui Du, Jiang Yu, Chaohui Zheng, Fenglin Liu, Ziyu Li, Gang Zhao, Jiachen Zhang, Pingyan Chen, Guoxin Li
Summary: The study found that laparoscopic distal gastrectomy with D2 lymphadenectomy performed by experienced surgeons in high-volume specialized institutions resulted in similar 5-year overall survival compared with open distal gastrectomy among patients with locally advanced gastric cancer. This randomized clinical trial reports 5-year overall survival data from the CLASS-01 trial of laparoscopic vs open distal gastrectomy among patients with locally advanced gastric cancer.
Article
Immunology
Ju-Li Lin, Jian-Xian Lin, Jun Peng Lin, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-bin Wang, Jun Lu, Qi-Yue Chen, Chang-Ming Huang
Summary: The study demonstrates that the combination of camrelizumab with nab-paclitaxel plus S-1 is safe and effective for the treatment of gastric cancer with serosal invasion. This treatment approach significantly improves tumor regression grade and the rate of pathologic complete response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jian-Xian Lin, Jun-Peng Lin, Yong Weng, Chen-Bin Lv, Jian-Hua Chen, Chuan-Yin Zhan, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Wen-Xing Zhou, Xiao-Jing Zhang, Chao-Hui Zheng, Li-Sheng Cai, Yu-Bin Ma, Chang-Ming Huang
Summary: The study developed a non-invasive radiological signature for assessing the immunosuppressive status and prognosis of gastric cancer, and identified patients with stage II and III gastric cancer who are most likely to benefit from adjuvant chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Jian-Xian Lin, Yi-Hui Tang, Guan-Jie Lin, Yu-Bin Ma, Jacopo Desiderio, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Amilcare Parisi, Mark J. Truty, Chang-Ming Huang
Summary: This cohort study compares the survival rates of patients with locally advanced gastric cancer who received adjuvant chemotherapy (AC) and those who did not after neoadjuvant chemotherapy followed by surgery. The study found that AC was associated with improved survival in patients with a lymph node ratio of at least 9%. These findings suggest that the lymph node ratio could be useful in AC selection for locally advanced gastric cancer in future decision-making processes.
Article
Oncology
Zi-Jian Deng, Jun Lu, Run-Cong Nie, Jia-Ming Fang, Xi-Jie Chen, Jun-Jie Liu, Xian-Zhe Li, Ying-Bo Chen, Chang-Ming Huang, Lei Lian, Jun-Sheng Peng, Shi Chen
Summary: This study aimed to explore the indications for adjuvant chemotherapy in patients with stage II gastric cancer by constructing an individual prediction model. It was found that high-risk patients may benefit from adjuvant chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Jin-Tao Li, Jian-Xian Lin, Fu-Hai Wang, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Chao-Hui Zheng, Chang-Ming Huang, Ping Li
Summary: This study compared the outcomes and long-term results of robotic radical gastrectomy and laparoscopic radical gastrectomy. The study found no significant differences in 3-year overall survival and 3-year relapse-free survival between the two groups. Robotic radical gastrectomy can achieve results comparable to laparoscopic surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Zu-Kai Wang, Jian-Xian Lin, Fu-Hai Wang, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: This study compared the intraoperative and postoperative short-term outcomes of robotic spleen-preserving splenic hilar lymphadenectomy (RSPSHL) and laparoscopic spleen-preserving splenic hilar lymphadenectomy (LSPSHL). The results showed that RSPSHL had more advantages in terms of surgical qualities and postoperative recovery process compared to LSPSHL, with similar morbidity and mortality rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Zu-Kai Wang, Jian-Xian Lin, Jiao-Bao Huang, Jun Lu, Ze-Ning Huang, Jian-Wei Xie, Jia-Bin Wang, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Hua-Long Zheng, Ping Li, Chao-Hui Zheng, Chang Ming Huang
Summary: This study evaluated the impact of a national advanced training program on laparoscopic radical gastrectomy. The results showed that the training had a significant improvement on trainees' general surgical skills, laparoscopic gastrectomy acceptance, and clinical research possibilities. Surgeons with lower professional titles and fewer performed operations were more likely to improve their general surgical skills through the training program.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Environmental Sciences
Yue Li, Yonglin Zhang, Jinxiang Cheng, Chaohui Zheng, Mingjun Li, Honglei Xu, Renjie Wang, Dongsheng Chen, Xiaotong Wang, Xinyi Fu, Yuehua Zhao, Rui Wu, Xiaowen Yang, Lan Shi
Summary: Ship exhaust emissions have a significant impact on global climate and human health. This study compiled and categorized inventory compilation methods of ship emissions and conducted a comparative analysis. Different methods varied in terms of applicability, accuracy, and resolution of results. The study recommended specific methods for different scales of ship emissions inventory compilations based on their performance in validation cases.
Article
Oncology
Guo-Sheng Lin, Jun Lu, Jia Lin, Hua-Long Zheng, Bin-Bin Xu, Zhen Xue, Dong Wu, Lili Shen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Qi-Yue Chen, Chang-Ming Huang
Summary: The preoperative DDI-to-albumin ratio (DAR) is a new biomarker for predicting long-term survival in gastric cancer (GC). A DAR > 0.0145 aids in the timely detection of early recurrence and peritoneal recurrence after surgery, guiding personalized follow-up strategies.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jia-Bin Wang, You-Xin Gao, Yin-Hua Ye, Tong-Xing Lin, Ping Li, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Ze-Ning Huang, Hua-Long Zheng, Jian-Wei Xie, Chao-Hui Zheng, Chang-Ming Huang
Summary: The study demonstrates that CDK5RAP3 plays a tumor suppressor role in gastric cancer and is related to the infiltration and polarization of macrophages. CDK5RAP3 inhibits TAMs polarization to M2 phenotype and promotes M1 polarization. In addition, CDK5RAP3 reduces monocyte recruitment to tumor tissue by inhibiting the CCL2/CCR2 axis.
CANCER GENE THERAPY
(2023)
Article
Oncology
Jian-Xian Lin, Jun-Peng Lin, Qing-Qi Hong, Peng Zhang, Zi-Zhen Zhang, Liang He, Quan Wang, Liang Shang, Lin-Jun Wang, Ya-Feng Sun, Zhi-Xiong Li, Jun-Jie Liu, Fang-Hui Ding, En-De Lin, Yong-An Fu, Shuang-Ming Lin, Ping Li, Zu-Kai Wang, Chao-Hui Zheng, Chang-Ming Huang, Jian-Wei Xie
Summary: This study developed a nomogram to predict postoperative recurrence of hepatoid adenocarcinoma of the stomach (HAS) and guide individualized surveillance strategies. The nomogram accurately stratified patients into low-, middle-, and high-risk groups of postoperative recurrence. Middle- and high-risk patients had higher rates of recurrence and metastasis, particularly multiple site metastasis, within 36 months after the operation.
ANNALS OF SURGICAL ONCOLOGY
(2023)