Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum

In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier

(2019) W. Richard Bevan-Jones et al.   Annals of Clinical and Translational Neurology

Effect of off-target binding on 18F-Flortaucipir variability in healthy controls across the lifespan

(2019) Suzanne L Baker et al.   JOURNAL OF NUCLEAR MEDICINE

In vivo18F-AV-1451 tau PET signal inMAPTmutation carriers varies by expected tau isoforms

(2018) David T. Jones et al.   NEUROLOGY

[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy

(2018) Luca Passamonti et al.   NEUROLOGY

A Highly Selective and Specific PET Tracer for Imaging of Tau Pathologies

(2018) Wei Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

18F-AV-1451 in Parkinson’s Disease with and without dementia and in Dementia with Lewy Bodies

(2018) Ruben Smith et al.   Scientific Reports

[18 F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion

(2018) Richard W. Bevan-Jones et al.   Annals of Clinical and Translational Neurology

Flortaucipir tau PET imaging in semantic variant primary progressive aphasia

(2017) Sara J Makaretz et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

[ 18 F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia

(2017) W R Bevan-Jones et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([18F]-AV-1451) Binding

(2017) Allan K. Hansen et al.   MOLECULAR IMAGING AND BIOLOGY

The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases

(2017) Céline Vermeiren et al.   MOVEMENT DISORDERS

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

In vivo retention of 18 F-AV-1451 in corticobasal syndrome

(2017) Ruben Smith et al.   NEUROLOGY

Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses

(2017) W Richard Bevan-Jones et al.   BMJ Open

Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration

(2016) Corey T. McMillan et al.   ACTA NEUROPATHOLOGICA

Characterization of tau positron emission tomography tracer [ 18 F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias

(2016) Kerstin Sander et al.   Alzheimers & Dementia

Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease

(2016) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology inMAPTmutation carriers

(2016) Ruben Smith et al.   BRAIN

C9orf72 is required for proper macrophage and microglial function in mice

(2016) J. G. ORourke et al.   SCIENCE

[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation

(2016) W. Richard Bevan Jones et al.   Annals of Clinical and Translational Neurology

An autoradiographic evaluation of AV-1451 Tau PET in dementia

(2016) Val J. Lowe et al.   Acta Neuropathologica Communications

Imaging neuroinflammation in Alzheimer's disease and other dementias: Recent advances and future directions

(2015) James Varley et al.   Alzheimers & Dementia

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

The Role of Neuroinflammation in Dementias

(2015) Giuseppe Pasqualetti et al.   Current Neurology and Neuroscience Reports

Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging

(2015) Jing Zhang   Journal of Neuroinflammation

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

(2013) Chun-Fang Xia et al.   Alzheimers & Dementia

TDP-43 frontotemporal lobar degeneration and autoimmune disease

(2013) Z. A. Miller et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

(2013) Margarita Giraldo et al.   NEUROBIOLOGY OF AGING

Patterns of microglial cell activation in frontotemporal lobar degeneration

(2013) Suzannah B. Lant et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Microglia, Amyloid and Glucose Metabolism in Parkinson’s Disease with and without Dementia

(2013) Paul Edison et al.   NEUROPSYCHOPHARMACOLOGY

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

Optimization of Supervised Cluster Analysis for Extracting Reference Tissue Input Curves in (R)-[11C]PK11195 Brain PET Studies

(2012) Maqsood Yaqub et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Progranulin Is a Chemoattractant for Microglia and Stimulates Their Endocytic Activity

(2011) Fiona Pickford et al.   AMERICAN JOURNAL OF PATHOLOGY

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

Anatomy of Language Impairments in Primary Progressive Aphasia

(2011) E. Rogalski et al.   JOURNAL OF NEUROSCIENCE

Classification of primary progressive aphasia and its variants

(2011) M. L. Gorno-Tempini et al.   NEUROLOGY

Progranulin expression in the developing and adult murine brain

(2010) Terri L. Petkau et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review

(2010) H. Seelaar et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: A PET and MRI study

(2010) Michie Miyoshi et al.   PARKINSONISM & RELATED DISORDERS

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

(2009) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Positron Emission Tomography Ligand DAA1106 Binds With High Affinity to Activated Microglia in Human Neurological Disorders

(2008) Sriram Venneti et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY