Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1+/−-driven murine colonic adenomas

Ongoing and future directions in the management of metastatic colorectal cancer: Update on clinical trials

(2019) Shailesh Advani et al.   JOURNAL OF SURGICAL ONCOLOGY

The multifaceted role of glutathione S-transferases in cancer

(2018) Anupam Chatterjee et al.   CANCER LETTERS

Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR

(2018) Hidejiro Torigoe et al.   CARCINOGENESIS

Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models

(2018) Janneke F. Linnekamp et al.   CELL DEATH AND DIFFERENTIATION

A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors

(2018) Mahmood Faraz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma

(2018) Feng Mao et al.   Oncogenesis

Expression of Lrig1, a negative regulator of EGFR, is dynamically altered during different stages of gastric carcinogenesis

(2018) Sungsook Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology

(2018) Nobuo Sasaki et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Intra-tumour diversification in colorectal cancer at the single-cell level

(2018) Sophie F. Roerink et al.   NATURE

From the Cover: High Susceptibility of Lrig1 Sebaceous Stem Cells to TCDD in Mice

(2017) Fabienne Fontao et al.   TOXICOLOGICAL SCIENCES

GenVisR: Genomic Visualizations in R

(2016) Zachary L. Skidmore et al.   BIOINFORMATICS

High-specificity detection of rare alleles with Paired-End Low Error Sequencing (PELE-Seq)

(2016) Jessica L. Preston et al.   BMC GENOMICS

Widespread intron retention diversifies most cancer transcriptomes

(2015) Heidi Dvinge et al.   Genome Medicine

Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis

(2014) Anne E. Powell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

(2014) Ludmil B Alexandrov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Track data hubs enable visualization of user-defined genome-wide annotations on the UCSC Genome Browser

(2013) B. J. Raney et al.   BIOINFORMATICS

Identification of somatic mutations in cancer through Bayesian-based analysis of sequenced genome pairs

(2013) Alexis Christoforides et al.   BMC GENOMICS

Stacks: an analysis tool set for population genomics

(2013) Julian Catchen et al.   MOLECULAR ECOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Deciphering Signatures of Mutational Processes Operative in Human Cancer

(2013) Ludmil B. Alexandrov et al.   Cell Reports

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

(2012) Vivian W. Y. Wong et al.   NATURE CELL BIOLOGY

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis

(2012) M Christie et al.   ONCOGENE

Whole-genome reconstruction and mutational signatures in gastric cancer

(2012) Niranjan Nagarajan et al.   GENOME BIOLOGY

ggplot2: Elegant Graphics for Data Analysis

(2011) Cedric Ginestet   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi

(2009) K. J. Ritchie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Interaction of Muc2 and Apc on Wnt Signaling and in Intestinal Tumorigenesis: Potential Role of Chronic Inflammation

(2008) K. Yang et al.   CANCER RESEARCH

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

(2008) Kevin M Haigis et al.   NATURE GENETICS