Review
Geriatrics & Gerontology
Firoz Akhter, Alicia Persaud, Younis Zaokari, Zhen Zhao, Donghui Zhu
Summary: Vascular dementia (VaD) is a type of dementia caused by reduced blood flow to the brain, accounting for 20% of all dementia cases. There are subtle differences in the presentation of VaD between males and females, but they are often overlooked.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Antoine Garnier-Crussard, Francois Cotton, Pierre Krolak-Salmon, Gael Chetelat
Summary: White matter hyperintensities (WMH) are vascular lesions frequently seen in older adults, but recent evidence suggests that non-vascular mechanisms, particularly in Alzheimer's disease (AD), may also contribute to WMH. This alternative hypothesis is supported by arguments from neuropathology, neuroimaging, fluid biomarkers, and genetics. The underlying mechanisms of AD-related WMH, such as neurodegeneration or neuroinflammation, are discussed, as well as the implications for AD diagnosis and management. Testing this hypothesis and addressing remaining challenges can improve personalized care for patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Benjamin B. Tournier, Silvia Sorce, Antoine Marteyn, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Francois R. Herrmann, Karl-Heinz Krause, Dina Zekry
Summary: This study investigates the links between CCR5 deficiency, neuronal sensitivity to oxidative stress, and the development of dementia. The results show that CCR5-& UDelta;32 allele, when combined with ApoE & epsilon;4, increases the risk for dementia, particularly vascular dementia. Additionally, Ccr5 deficiency in mice neurons leads to increased vulnerability to oxidative stress-induced cell death, suggesting a possible mechanism contributing to dementia.
ALZHEIMERS & DEMENTIA
(2023)
Review
Geriatrics & Gerontology
Xuanlin Li, Lin Huang, Yujun Tang, Xuanming Hu, Chengping Wen
Summary: The aim of this meta-analysis was to evaluate the risk of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VD) in gout patients. The results showed that gout patients had a lower risk of all-cause dementia, AD, and VD, but the quality of evidence was generally low, and more studies are needed to validate and explore the mechanisms of this association.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Min Young Chun, Hyemin Jang, Soo-Jong Kim, Yu Hyun Park, Jihwan Yun, Samuel N. Lockhart, Michael Weiner, Charles De Carli, Seung Hwan Moon, Jae Yong Choi, Kyung Rok Nam, Byung-Hyun Byun, Sang-Moo Lim, Jun Pyo Kim, Yeong Sim Choe, Young Ju Kim, Duk L. Na, Hee Jin Kim, Sang Won Seo
Summary: Alzheimer's disease (AD) is characterized by amyloid-beta accumulation, tau aggregation, and neurodegeneration. Vascular burden has synergistic effects on cognitive decline with AD biomarkers. The distribution and longitudinal outcomes of AT(N) categories differ according to vascular burden, emphasizing the importance of incorporating a vascular biomarker into the AT(N) system.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
So Yeong Cheon, Juhyun Song
Summary: Non-alcoholic fatty liver disease (NAFLD) and dementia share common pathological characteristics, and further research is needed to understand their association and find appropriate treatment options.
CELL AND BIOSCIENCE
(2022)
Article
Geriatrics & Gerontology
Wenxiu Wang, Yongchun Luo, Zhenhuang Zhuang, Zimin Song, Ninghao Huang, Yueying Li, Xue Dong, Wendi Xiao, Yimin Zhao, Tao Huang
Summary: The study found an L-shaped association between total and regional fat-to-muscle mass ratio and dementia risk among participants aged 60 and older, independent of overall obesity.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Environmental Sciences
Jung-Im Shim, Garam Byun, Jong-Tae T. Lee
Summary: This study investigated the association between long-term exposure to PM10 and the risk of developing Alzheimer's disease and vascular dementia in the elderly population. The results showed a significant link between long-term PM10 exposure and the risk of developing vascular dementia, but not Alzheimer's disease.
ENVIRONMENTAL HEALTH
(2023)
Review
Neurosciences
Sally Day, Stefanie Roberts, Nathalie H. Launder, Anita M. Y. Goh, Brian Draper, Alex Bahar-Fuchs, Samantha M. Loi, Kate Laver, Adrienne Withall, Monica Cations
Summary: Younger people with Alzheimer's disease (AD) have a worse prognosis in terms of faster cognitive decline compared to older individuals. More research is needed to determine the impact of symptom onset age in vascular dementia (VaD) and frontotemporal dementia (FTD), as well as functional decline in all types of dementias.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Xuewen Xiao, Lina Guo, Xinxin Liao, Yafang Zhou, Weiwei Zhang, Lu Zhou, Xin Wang, Xixi Liu, Hui Liu, Tianyan Xu, Yuan Zhu, Qijie Yang, Xiaoli Hao, Yingzi Liu, Junling Wang, Jinchen Li, Bin Jiao, Lu Shen
Summary: Common variants in COL4A1 and rare variants in HTRA1, NOTCH3, COL4A1, and CST3 may be implicated in AD pathogenesis in the Chinese population. Additionally, GSN, ITM2B, and COL4A1 are probably involved in the development of AD endophenotypes.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Blossom C. M. Stephan, Denise M. Gaughan, Steven Edland, Villi Gudnason, Lenore J. Launer, Lon R. White
Summary: In this study, neuropathological-based risk scores were used to predict clinical dementia, and different models were identified for predicting neurodegenerative and vascular neuropathology. The findings suggest that there may be shared risk factors and pathways across dementia-related lesions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Christian Lachner, Gregory S. Day, Gamze Balci Camsari, Naomi Kouri, Nilufer Ertekin-Taner, Bradley F. Boeve, Sydney A. Labuzan, John A. Lucas, E. Aubrey Thompson, Habeeba Siddiqui, Julia E. Crook, Janisse N. Cabrera-Rodriguez, Keith A. Josephs, Ronald C. Petersen, Dennis W. Dickson, R. Ross Reichard, Michelle M. Mielke, David S. Knopman, Neill R. Graff-Radford, Melissa E. Murray
Summary: In the oldest-old population, there is a relationship between diabetes, coronary artery disease, cancer, and the occurrence of dementia. Diabetes is associated with an increase in cerebrovascular pathology, while cancer is associated with a decrease in dementia occurrence and tangle pathology.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Xin Ying Chua, Federico Torta, Joyce R. Chong, Narayanaswamy Venketasubramanian, Saima Hilal, Markus R. Wenk, Christopher P. Chen, Thiruma V. Arumugam, Deron R. Herr, Mitchell K. P. Lai
Summary: AD and VaD are associated with distinct changes of plasma sphingolipids, and specific combinations of sphingolipids panels have higher sensitivity and specificity for classification of AD and VaD, compared to NCI.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Review
Geriatrics & Gerontology
Leo Sokolovic, Markus J. Hofmann, Nadia Mohammad, Juraj Kukolja
Summary: This study aimed to identify diagnostic instruments that distinguish between Alzheimer's disease (AD) and vascular dementia (VaD). The findings showed that AD patients performed worse in episodic memory and better in working memory compared to VaD patients. There was little support for other differences proposed by diagnostic systems and guidelines. The utility of cognitive, behavioral, psychiatric, and functional measures in differential diagnosis is limited and should be complemented by other information.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Clinical Neurology
Jonathan Pansieri, Gina Hadley, Andrew Lockhart, Marco Pisa, Gabriele C. C. DeLuca
Summary: The maintenance of adequate blood supply and vascular integrity is crucial for cerebral function. Vascular dysfunction has been reported in white matter dementias, which are characterized by white matter damage in the brain and cognitive impairment. This review provides an overview of vascular-specific regional alterations in white matter dementia, discusses the contribution of cerebral blood flow and blood-brain barrier disturbances in different conditions, and proposes a hypothetical map of vascular dysfunction to guide future research and therapeutic development.
FRONTIERS IN NEUROLOGY
(2023)
Letter
Allergy
Anna M. Hedman, Cecilia Lundholm, Annika Scheynius, Johan Alm, Ellika Andolf, Goeran Pershagen, Catarina Almqvist
Article
Multidisciplinary Sciences
Beatrice Kennedy, Sari Peura, Ulf Hammar, Silvia Vicenzi, Anna Hedman, Catarina Almqvist, Ellika Andolf, Goran Pershagen, Johan Dicksved, Stefan Bertilsson, Tove Fall
SCIENTIFIC REPORTS
(2019)
Article
Obstetrics & Gynecology
Parnian Kheirkhah Rahimabad, Syed Hasan Arshad, John W. Holloway, Nandini Mukherjee, Anna Hedman, Olena Gruzieva, Ellika Andolf, Juha Kere, Goran Pershagen, Catarina Almqvist, Yu Jiang, Su Chen, Wilfried Karmaus
Summary: This study identified an association between maternal DNA methylation during pregnancy and offspring birthweight, with 8 candidate CpGs being significantly correlated. Replication studies found 3 CpGs to be marginally significant in association with 4 genes related to birthweight. Biological pathway analyses suggested potential cellular and metabolic processes that may influence birthweight outcomes.
REPRODUCTIVE SCIENCES
(2021)
Article
Immunology
Divya Thiagarajan, Susanna L. Lundstrom, Goran Pershagen, Catarina Almqvist Malmros, Ellika Andolf, Anna Hedman, Oscar Berg, Nina Oparina, Johan Frostegard
JOURNAL OF IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Anna M. Hedman, Cecilia Lundholm, Ellika Andolf, Goran Pershagen, Tove Fall, Catarina Almqvist
SCIENTIFIC REPORTS
(2020)
Article
Obstetrics & Gynecology
Elmar W. Tobi, Catarina Almqvist, Anna Hedman, Ellika Andolf, Jan Holte, Jan Olofsson, Hakan Wramsby, Margaretha Wramsby, Goran Pershagen, Bastiaan T. Heijmans, Anastasia N. Iliadou
Summary: The study found an association between ART conception and DNAm differences in cord blood, with no differences between IVF and ICSI. Although DNAm at genes related to brain function and subfertility was identified, the functional consequences remain unknown.
HUMAN REPRODUCTION
(2021)
Correction
Immunology
D. Thiagarajan, S. L. Lundstrom, G. Pershagen, C. Almqvist, E. Andolf, A. Hedman, O. Berg, N. Oparina, J. Frostegard
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mona-Lisa Wernroth, Sari Peura, Anna M. Hedman, Susanne Hetty, Silvia Vicenzi, Beatrice Kennedy, Katja Fall, Bodil Svennblad, Ellika Andolf, Goran Pershagen, Jenny Theorell-Haglow, Diem Nguyen, Sergi Sayols-Baixeras, Koen F. Dekkers, Stefan Bertilsson, Catarina Almqvist, Johan Dicksved, Tove Fall
Summary: This study used 16S rRNA sequencing to analyze fecal and saliva samples from infants and their mothers at four time points during the first 2 years of life. The findings showed that gut microbiota in infants have low diversity and share some properties with the oral microbiota. The composition of gut microbiota undergoes a significant shift during the first 2 years of life, towards a more diverse adult-like microbiota.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Shizhen He, Susanna Klevebro, Gabriel Baldanzi, Goran Pershagen, Bjorn Lundberg, Kristina Eneroth, Anna M. Hedman, Ellika Andolf, Catarina Almqvist, Matteo Bottai, Erik Melen, Olena Gruzieva
Summary: This study aims to investigate the association between air pollution exposure and inflammation-related proteins in young children. The results show that ambient air pollution exposure influences inflammation-related protein levels during early childhood, with age- and sex-specific differences.
ENVIRONMENTAL RESEARCH
(2022)
Article
Economics
Jenny Berg, Karin Kallen, Ellika Andolf, Lena Hellstrom-Westas, Cecilia Ekeus, Jonatan Alvan, Sigurd Vitols
Summary: This study evaluated the cost-effectiveness of cesarean section (CS) on maternal request compared with planned vaginal birth in a Swedish context. The results showed that planned vaginal birth leads to lower healthcare costs and better somatic health outcomes compared to elective CS without medical indication. Although there is uncertainty, the results remained stable across sensitivity analyses.
Article
Public, Environmental & Occupational Health
Maria Sahlin, Ingela Wiklund, Ellika Andolf, Monika Lofgren, Anna-Karin Klint Carlander
Summary: Women who underwent caesarean sections in the 1970s and 1980s in Sweden often described the experience as an undesired life event, with main aspects including vaginal birth as the norm, a total loss of control, and acceptance and contact with the child. The lack of knowledge about operative childbirth and preparation for a complicated birth and postpartum care led to psychological harm, which was eventually overcome through acceptance of their negative experience.
SEXUAL & REPRODUCTIVE HEALTHCARE
(2021)
Article
Genetics & Heredity
Rui Luo, Nandini Mukherjee, Su Chen, Yu Jiang, S. Hasan Arshad, John W. Holloway, Anna Hedman, Olena Gruzieva, Ellika Andolf, Goran Pershagen, Catarina Almqvist, Wilfried J. J. Karmaus
EPIGENETICS INSIGHTS
(2020)
Article
Genetics & Heredity
Olena Gruzieva, Simon Kebede Merid, Su Chen, Nandini Mukherjee, Anna M. Hedman, Catarina Almqvist, Ellika Andolf, Yu Jiang, Juha Kere, Annika Scheynius, Cilia Soderhall, Vilhelmina Ullemar, Wilfried Karmaus, Erik Melen, Syed Hasan Arshad, Goran Pershagen
EPIGENETICS INSIGHTS
(2019)
Article
Medical Laboratory Technology
Tove Fall, Anna Hedman, Goran Pershagen, Ellika Andolf, Catarina Almqvist, Johanna Helmersson-Karlqvist, Anders Larsson
CLINICAL LABORATORY
(2019)