Enzymes for pharmaceutical and therapeutic applications

Intrinsic dynamic behavior of enzyme:substrate complexes govern the catalytic action of β-galactosidases across clan GH-A

(2019) Rajender Kumar et al.   Scientific Reports

Effects of α-galactosidase supplementation on nutrient digestibility, growth performance, intestinal morphology and digestive enzyme activities in weaned piglets

(2018) Q.H. Shang et al.   ANIMAL FEED SCIENCE AND TECHNOLOGY

Biocatalysis for synthesis of pharmaceuticals

(2018) Ramesh N. Patel   BIOORGANIC & MEDICINAL CHEMISTRY

Could enzyme replacement therapy promote immune tolerance in Gaucher disease type 1?

(2018) Marina Cadena Matta et al.   BLOOD CELLS MOLECULES AND DISEASES

Enzymatic asymmetric synthesis of chiral amino acids

(2018) Ya-Ping Xue et al.   CHEMICAL SOCIETY REVIEWS

Enzyme evolution: innovation is easy, optimization is complicated

(2018) Matilda S .Newton et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid

(2018) Agnieszka Siebert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microbial serine protease inhibitors and their therapeutic applications

(2018) B.S Harish et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Characterization of d -succinylase from Cupriavidus sp. P4-10-C and its application in d -amino acid synthesis

(2018) Yosuke Sumida et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Emerging Biomedical Applications of Enzyme-Like Catalytic Nanomaterials

(2018) David P. Cormode et al.   TRENDS IN BIOTECHNOLOGY

Enzymatic synthesis of sitagliptin intermediate using a novel ω-transaminase

(2018) Geon-Hee Kim et al.   ENZYME AND MICROBIAL TECHNOLOGY

Enzyme Replacement Therapy in a Gaucher Family

(2017) Neslihan Erdem et al.   JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION

Enzymatic preparation of optically pure t -butyl 6-chloro-(3 R ,5 S )-dihydroxyhexanoate by a novel alcohol dehydrogenase discovered from Klebsiella oxytoca

(2017) Tingting Xu et al.   PROCESS BIOCHEMISTRY

Microfluidic reactors with immobilized enzymes—Characterization, dividing, perspectives

(2017) Kinga Meller et al.   SENSORS AND ACTUATORS B-CHEMICAL

Improved synthesis of unnatural amino acids for peptide stapling

(2017) Bo Li et al.   TETRAHEDRON LETTERS

Microalgae and cyanobacteria as enzyme biofactories

(2017) Bruno dos Santos Alves Figueiredo Brasil et al.   Algal Research-Biomass Biofuels and Bioproducts

In-silico driven engineering of enantioselectivity of a penicillin G acylase towards active pharmaceutical ingredients

(2016) Michal Grulich et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Substrate screening of amino transaminase for the synthesis of a sitagliptin intermediate

(2016) Anwei Hou et al.   TETRAHEDRON

An improved, scalable synthesis of bis-amino acids

(2016) Jae Eun Cheong et al.   TETRAHEDRON LETTERS

Penicillin V acylase from Pectobacterium atrosepticum exhibits high specific activity and unique kinetics

(2015) V.S. Avinash et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Enhancement of l-cysteine production by disruption of yciW in Escherichia coli

(2015) Yusuke Kawano et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Stereoselective synthesis of 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitors

(2015) Yan Wu et al.   TETRAHEDRON

Enantioselective synthesis of (S)-3-cyano-5-methylhexanoic acid by a high DMSO concentration tolerable Arthrobacter sp. ZJB-09277

(2014) Ren-Chao Zheng et al.   BIOCHEMICAL ENGINEERING JOURNAL

Stereoselective synthesis of l-tert-leucine by a newly cloned leucine dehydrogenase from Exiguobacterium sibiricum

(2014) Jing Li et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Current developments in solid-state fermentation

(2013) Leya Thomas et al.   BIOCHEMICAL ENGINEERING JOURNAL

Recent advances in enzymatic and chemical deracemisation of racemic compounds

(2013) Michał Rachwalski et al.   CHEMICAL SOCIETY REVIEWS

Bioconversion process for synthesis of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate using liquid-core immobilized Saccharomyces cerevisiae CGMCC No 2233

(2012) Sun Xingyuan et al.   KOREAN JOURNAL OF CHEMICAL ENGINEERING

TECHNOLOGY PROSPECTING ON ENZYMES: APPLICATION, MARKETING AND ENGINEERING

(2012) Shuang Li et al.   Computational and Structural Biotechnology Journal

Dynamic Kinetic Resolution of α-Aminonitriles to Form Chiral α-Amino Acids

(2011) Kazuyuki Yasukawa et al.   ADVANCED SYNTHESIS & CATALYSIS

Racemase Activity of B. cepacia Lipase Leads to Dual-Function Asymmetric Dynamic Kinetic Resolution of α-Aminonitriles

(2011) Pornrapee Vongvilai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deracemisation of Mandelic Acid to Optically Pure Non-Natural L-Phenylglycine via a Redox-Neutral Biocatalytic Cascade

(2010) Verena Resch et al.   ADVANCED SYNTHESIS & CATALYSIS

Dehydrogenases/Reductases for the Synthesis of Chiral Pharmaceutical Intermediates

(2010) Yan Huang et al.   CURRENT ORGANIC CHEMISTRY

Biocatalytic synthesis of atorvastatin intermediates

(2009) Jay M. Patel   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

From Basic Science to Blockbuster Drug: The Discovery of Lyrica

(2008) Richard B. Silverman   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION