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Oncology
Xiaohui Zhang, Tingyu Li, Ya-Nan Han, Minghui Ge, Pei Wang, Lina Sun, Hao Liu, Tianyu Cao, Yongzhan Nie, Daiming Fan, Hao Guo, Kaichun Wu, Xiaodi Zhao, Yuanyuan Lu
Summary: In this study, we identified a novel mechanism by which miR-125b enhances metastasis in CRC by targeting CFTR and CGN, promoting EMT and uPA expression and secretion, and enhancing RhoA/ROCK signaling pathway. These findings suggest miR-125b as a key functional molecule in CRC and a promising biomarker for the diagnosis and treatment of CRC.
Article
Oncology
Shuyun Wang, Limin Nie, Yuxiao Song, Fang Zhang, Xiaozheng Chen, Wenjing Shi, Zijiang Yang, Yuping Sun, Qi Dang, Aiqin Gao
Summary: The study found that NRTN is enriched in colorectal cancer cells and predicts poor patient outcomes. Upregulated NRTN enhances cancer cell motility and angiogenesis, promoting tumor invasion and metastasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Zhipeng Jiang, Hao Hu, Wenli Hu, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen
Summary: This study aimed to investigate the role of circ-RNF121 in colorectal cancer (CRC). The results showed that circ-RNF121 silencing inhibited cell proliferation, migration, invasion, and glycolysis while inducing cell apoptosis in CRC. Additionally, circ-RNF121 acted as a sponge for miR-1224-5p and was involved in tumor growth inhibition in vivo. This finding sheds new light on circRNA-mediated therapy for CRC.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Chengxing Wang, Bin Wang, Weijun Liang, Chaorong Zhou, Weixing Lin, Zijie Meng, Wanting Wu, Meimei Wu, Yuehua Liao, Xiaoping Li, Jinglin Zhao, Yaoming He
Summary: This study identified hsa-miR-1248 as a potential tumor suppressor gene in colorectal cancer by targeting and inhibiting PSMD10, providing a potential therapeutic target for CRC treatment.
Article
Biochemistry & Molecular Biology
Jiawei Sun, Zizhen Zhang, Jingyu Chen, Meng Xue, Xia Pan
Summary: High expression of ELTD1 is correlated with lymph node metastasis and poor outcomes in colorectal cancer, promoting invasion and metastasis of CRC both in vitro and in vivo. Additionally, ELTD1 accelerates MMP2 transcriptional activity, potentially serving as a novel target for CRC metastasis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Rui Chen, Qiyu Gan, Shuting Zhao, Dongrui Zhang, Shunli Wang, Lili Yao, Min Yuan, Jingxin Cheng
Summary: miR-138 is identified as a tumor suppressor in various cancers, and in cervical cancer its downregulation is associated with higher tumor aggressiveness. miR-138 functions by targeting EZH2 to inhibit proliferation, invasion, metastasis, and EMT in cervical cancer cells. The findings suggest that miR-138 could serve as a potential biomarker for disease metastasis prediction and a therapeutic target for cervical cancer.
Article
Cell Biology
Xiaoguang Gu, Jianan Zhang, Yajuan Ran, Hena Pan, JinHong Jia, Ying Zhao, Xijuan Zhao, Wendi Li, Shasha Song, Xiufeng Yu
Summary: The study revealed the role of hsa_circ_101555 in HCC, potentially acting as a competing endogenous RNA for miR-145-5p to upregulate CDCA3 expression. Silencing hsa_circ_101555 significantly suppressed cell proliferation, migration, and invasion of HCC cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Yang Bai, Ling Li, Zhiyong Zhang
Summary: This study found that Linc00883 plays a promoting role in the proliferation, invasion, and migration of colorectal cancer cells, and this function is achieved through regulating the miR-577/FKBP14 axis.
Article
Cell Biology
You Yu, Xiao Lei
Summary: This study investigated a novel circRNA circFAM120B in colorectal cancer (CRC) development. CircFAM120B inhibited CRC progression by mediating the miR-645/TGFBR2 network.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Yi Zhang, Hongmei Yong, Jing Fu, Guangyi Gao, Huichang Shi, Xueyi Zhou, Mingsheng Fu
Summary: The study revealed that miR-504 was significantly upregulated in gastric cancer tissues, while RBM4 was significantly downregulated. By targeting RBM4, miR-504 promoted cell proliferation and inhibited apoptosis in SGC-7901 cells.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Biology
Weiyu Dai, Linjie Hong, Wushuang Xiao, Luyu Zhang, Weihong Sha, Zhen Yu, Xuehua Liu, Side Liu, Yizhi Xiao, Ping Yang, Ying Peng, Jieming Zhang, Jianjiao Lin, Xiaosheng Wu, Weimei Tang, Zhizhao Lin, Li Xiang, Jiaying Li, Miaomiao Pei, Jide Wang
Summary: miR-3913-5p inhibits tumor progression in colorectal cancer and achieves this through regulating the expressions of CREB5 and ATF2.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Lin Zhou, Jian Li, Yaping Tang, Mei Yang
Summary: The study revealed that exosomal LINC00659 derived from CAFs promotes CRC cell proliferation, invasion, and migration through the miR-342-3p/ANXA2 pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Junfeng Qiu, Mingzhou Li, Cailin Su, Yihao Liang, Ruizhang Ou, Xiaoning Chen, Chengmei Huang, Yaxin Zhang, Yaping Ye, Wenting Liao, Chao Zhang
Summary: This study found that in colorectal cancer (CRC), the expression of FOXS1 is upregulated and is positively correlated with poor survival. FOXS1 promotes malignant behavior of CRC cells, including proliferation, invasion, and angiogenesis, both in vitro and in vivo. Mechanistically, FOXS1 upregulates the transcriptional level of CXCL8 to regulate tumor growth and metastasis. These findings suggest that the FOXS1/CXCL8 axis may serve as a potential therapeutic target for the treatment of metastatic CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu
Summary: miR-590-3p delivered through exosomes derived from CAFs enhances radioresistance in CRC by positively regulating the CLCA4-dependent PI3K/Akt signaling pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
